Caffeine Associated with Exercise Actions on Glycemic Metabolism and Insulin Resistance in Diabetic Animals – Pages 205-211

Caffeine Associated with Exercise Actions on Glycemic Metabolism and Insulin Resistance in Diabetic Animals

Pages 205-211

Luiz Augusto da Silva1,4, Jéssica Wouk2, Vinicius Muller Reis Weber3, Leandro Ricardo Altimari3, Antônio Carlos Dourado3, Carlos Ricardo Maneck Malfatti2 and Raul Osiecki4

1Guairacá College, Physical Education Collegiate, Guarapuava, Paraná, Brazil; 2Midwest State University of Paraná, Guarapuava, Paraná, Brazil; 3Londrina State University, Physical Education and Sport Center, Londrina, Paraná, Brazil; 4Post-Graduation of Physical Education, Federal university of Paraná, Curitiba, Paraná, Brazil

DOI: https://doi.org/120.29169/1927-5951.2018.08.04.8

Abstract: Objective: evaluate glycemic metabolism and its relationship with insulin resistance in diabetic animals after caffeine consumption associated with exercise.

Material and Methods: 48 animals, of 60 days, divided in four groups: Control, Diabetic, Control+Exercise, Diabetes+Exercise, Caffeine, Diabetes+Caffeine, Exercise+Caffeine and Diabetes+Caffeine+Exercise. Diabetes model was induced by intraperitoneal administration of 120 mg/kg of alloxan. On the test day, 6 mg/kg of caffeine were administrated 30 minutes before exercise and the animals performed a 60 minutes’ session of predominantly aerobic exercise, using an overload of 6% of their body’s weight. With 90 days old, the animals were submitted to an oral glucose tolerance test (OGTT) to verify their glycemic curve. During thirty days of aerobic exercise and/or caffeine treatment, the animals had their glycemia evaluated. At the end of the period, the OGTT was re-evaluated. So, the animals were sacrificed for biochemical analysis (glucose, muscle glycogen and hepatic) and hormonal (insulin). The animals were trained during 30 days by swimming tank, with 4% of extra weight a 40-minute session, daily.

Results: Caffeine treatment increased plasma insulin concentration compared to healthy controls (95%, p <0.05). Insulin resistance also reduced for trained diabetic animals treated with caffeine compared to healthy animals (IRI, OGTT and HOMA-IR).

Conclusion: Caffeine and training with aerobic exercise in healthy and diabetic animals’ improve biologic systems, increasing the physical ability of the body to resist situations seeking to adapt the tissues to better function.

Keywords: Metabolism, Insulin resistance, Glucose.