Cyclic Voltammetry of Trazodone as [piperazin-1-yl] Antidepressant Drug and Bovine Serum Albumin Binding Pages 351-357

Cyclic Voltammetry of Trazodone as [piperazin-1-yl] Antidepressant Drug and Bovine Serum Albumin Binding
Pages 351-357Creative Commons License

Iffat Azeem, Shaikh Mohiuddin and Arooj Fatima

DOI: http://dx.doi.org/10.6000/1927-5129.2016.12.54
Published: 26 August 2016

Abstract: The electrochemical behavior of trazodone (TRZ), 2-{3-[4-(3-chlorophenyl)piperazin-1-yl] propyl}-2H,3H-[1,2,4]triazolo[4,3-a]pyridin-3-one has been investigated bycyclic voltammerty measurements at glassy carbon working electrode. The voltammetric method includes selection of supporting electrolyte, pH, scan rate and temperature optimization; and measurements of some other basic voltammetric parameters. The TRZ oxidation peaks are decreased as a result of TRZ-BSA binding. TRZ-BSA binding mechanism is also established.

Keywords: Piperazine -1-yl class, drug-protein binding, electrochemical method development, voltammetric parameter optimization, serotonin antagonist and reuptake inhibitor.