Study of Multi-Drug Resistance Associated with Anti-Tuberculosis Treatment by DOT Implementation Strategy in Pakistan – Pages 107-112

Study of Multi-Drug Resistance Associated with Anti-Tuberculosis Treatment by DOT Implementation Strategy in Pakistan

Pages 107-112

Sana Saeed1, Moosa Raza1, Maryam Shabbir1, Muhammad Furqan Akhtar2, Ali Sharif1, Muhammad Zaman1, Sajid Ali1, Sajid Nawaz1 and Ayesha Saeed1

1Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan; 2Government College University, Faisalabad, Pakistan

https://doi.org/10.6000/1927-5129.2018.14.15

Abstract: Purpose: The present prospective cross sectional study was aimed to access the prevalence and trend of Multi-Drug Resistant Tuberculosis (MDR-TB) in different age groups and gender, in the city of Lahore, Pakistan. Tuberculosis is a disease of poverty affecting mostly young adults in their most productive years; however, all age groups are at risk.

Method: The study population consisted of patients under DOT program with MDR-TB among males and females and in different categories of age groups. The data was collected from 100 MDR-TB patients from 7800 TB patients that were admitted in duration of 6 months and analyzed to evaluate the drug resistance associated with patient’s noncompliance. Moreover, drugs resistance ratio was also calculated from the data.

Results: TB is a specific infectious disease, caused by M. tuberculosis strains, which is becoming resistant to anti-tuberculosis agents especially to Isoniazid and Rifampicin that are two key drugs of TB treatment and are termed as MDR-TB. The disease was seen in 66% males and 34% in female. The highest drug resistance ratio was in found in adults (age group).

Keywords: Multi Drug Resistance, Tuberculosis, DOT, Lahore, M. tuberculosis.