Analgesic and Anti-Inflammatory Effects of Phaseolus vulgaris L. Fixed Oil in Rodents – Pages 174-179

Analgesic and Anti-Inflammatory Effects of Phaseolus vulgaris L. Fixed Oil in Rodents

Pages 174-179

Salma1, Sadia Ghousia Baig1, Muhammad Mohtasheem ul Hasan2, Salman Ahmed2 and Syeda Anum Fatima1

1Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan; 2Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan

https://doi.org/10.6000/1927-5129.2018.14.26

Abstract: The seeds of Phaseolus vulgaris are known as common beans or kidney beans. The dry seeds are eaten as pulse and are enriched with protein, fiber, starch, B vitamins (B1, B6, B9), iron, potassium and selenium. Beans also contain about 1-2 % of fixed oil. Phaseolus vulgaris is linked with anticancer, antihyperlipidemic, hypoglycemic and antioxidant actions. The fixed oil of Phaseolus vulgaris (PVFO) seeds is extracted with hexane and used in this study to assess acute oral toxicity, analgesic (by acetic acid induced writhing, hot plate and tail flick tests in mice) and anti-inflammatory (by carrageenan induced paw edema in rats) actions. Four groups were made (n=6): Group-I: Normal Saline Control (2ml/kg), Group-II: PVFO (2ml/kg), Group-III: PVFO (4ml/kg) and Group-IV: Standard Acetyl salicylic acid (ASA 300 mg/kg). PVFO in 2ml/kg and 4ml/kg dose demonstrated analgesic and anti-inflammatory activities but in hot plate results were unreliable as here significant activity started after 90 minutes. For toxicity test 5ml/kg dose was administered orally in mice and no toxicity symptoms were observed. It is therefore concluded that PVFO is safe for oral use up to 5ml/kg and may possess analgesic and anti-inflammatory actions.

Keywords: Analgesic, anti-inflammatory, fixed oil, kidney beans, Phaseolus vulgaris.