Protective Measures to Enhance Human Longevity and Aging: A Review of Strategies to Minimize Cellular Damage – Pages 92-105

Protective Measures to Enhance Human Longevity and Aging: A Review of Strategies to Minimize Cellular Damage

Pages 92-105

Umesh C. Gupta1 and Subhas C. Gupta2

1Emeritus Research Scientist, Agriculture and Agri-Food Canada, Charlottetown Research and Development Centre, 440 University Avenue, Charlottetown, PE, C1A 4N6, Canada; 2Chairman and Professor, The Department of Plastic Surgery, Loma Linda University School of Medicine, Loma Linda, California 92354, USA

https://doi.org/10.29169/1927-5129.2019.15.12

Abstract: Aging is a universal process in all life forms. The most current and widely accepted definition of human aging is a progressive loss of function and energy production that is accompanied by decreased fertility and increased mortality with advancing age. The most obvious and commonly recognized consequence of aging and energy decline is a decrease in skeletal muscle function, which affects every aspect of human life from the ability to walk and run, to chew, and swallow and digest food. Some crucial factors responsible for aging and longevity include genetics, environment, and nutrition, serious disease disorders such as cancer and cardio-vascular diseases, sarcoma and cell senescence. Oxidative damage caused due to the accumulation of molecular waste-by-products of the body’s metabolic processes, which our bodies are unable to break down or excrete, is chiefly responsible for aging and diseases. Regular physical activity, consumption of foods rich in phytochemicals and anti-oxidants, cessation of smoking, avoiding foods high in saturated and hydrogenated fats are some of the strategies that should be taken into account to delay aging and prolong longevity.

Keywords: Caloric restriction, cellular damage, bone mass, Mediterranean diet, mitochondria, telomere length.