Efficacy of Metronidazole in Combination with Amoxicillin and Doxycycline in Adult Periodontitis – Pages 99-104

Efficacy of Metronidazole in Combination with Amoxicillin and Doxycycline in Adult Periodontitis – Pages 99-104

Sarah Moideen1, Rafeeq Alam Khan2 and Afaq Ahmed Siddiqui3

1Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan; 2College of Medicine-Jeddah King Saud Bin Abdul-Aziz University for –Health Sciences, Saudi Arabia; 3Department of Pharmaceutical Chemistry Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan

http://dx.doi.org/10.6000/1927-5129.2013.09.16

Abstract: Objective:Periodontal diseases are amongst most prevalent diseases in the world. They are caused by poor oral hygiene, accumulation of dental plaque and virulent putative pathogens on the teeth and gums Systemic antibiotics are used as adjuncts for the treatment of this infective disease. The objective of this study was to compare the efficacy of two antibiotic drug combinations i.e., Metronidazole with Amoxicillin and Metronidazole with Doxycycline in patients with adult periodontitis.

Method:50 patients were divided in two groups. They were given fixed doses for 7 days to patients with Adult Periodontitis. Readings were taken before treatment and two weeks prior to the treatment. The result was evaluated on the basis of periodontal Pocket depth, Bleeding Index and Mobility Index. The readings were taken using Periodontal Probe, dental Mirror and dental Explorer.

Result: There was significant reduction (p<0.01) observed in periodontal pocket depth and Bleeding Index incase of Doxycycline, Metronidazole combination in comparison to Amoxicillin, Metronidazole combination. There was slight change observed on Mobility Index.

Conclusion: The study suggested that Doxycycline and Metronidazole should be preferably given for Adult Periodontitis.

Keywords: Adult periodontitis, putative pathogens, pocket depth, bleeding index, mobility index.