Mallotus Mollissimus and Solanum Erianthum Exhibit Antikinase, Antiphosphatase and Anti-Cancer Properties

Pages 93-100

Nurul Ain Ismail1, Azlinah Matawali2, Ping-Chin Lee1, Siew-Eng How1, Latifah Saiful Yazan3, Lucky Poh Wah Goh1 and Jualang Azlan Gansau1

1Faculty of Science and Natural Resources, Universiti Malaysia Sabah, Jalan UMS, 88400 Kota Kinabalu, Sabah, Malaysia; 2Preparatory Centre for Science and Technology, Universiti Malaysia Sabah, Jalan UMS 88400 Kota Kinabalu, Sabah, Malaysia; 3Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia


Abstract: Cancer is a leading cause of death worldwide and caused by dysregulated signal transduction from kinase and phosphatases. Inhibitors of kinase and phosphatase have demonstrated anticancer properties. Therefore, this study aimed to investigate the antikinase, antiphosphatase and cytotoxic properties of Mallotus mollissimus (M. mollissimus) and Solanum erianthum (S. erianthum). Toxic activities against PP1, MKK1 and MSG5 assays were demonstrated by S. erianthum methanol extract. Bioassay-guided fractionation of the methanolic extracts showed that chloroform fraction (CE) of M. mollissimus exhibited toxic activity against PP1. Meanwhile, CE of S. erianthum showed positive activity on PP1 assay. Column chromatography separation of the CE has revealed that fractions F1 and F2 of M. mollissimus are toxic against PP1. Meanwhile, F1 and F2 CE fractions of S. erianthum were positive against PP1 and F9 fraction showed toxic activity in PP1 assay. Chloroform extracts of both plants exhibit cytotoxicity activity against HeLa, CaOV3 and MCF7 cell lines. This study demonstrated the potential of M. mollissimus and S. erianthum extracts in antikinase, antiphosphatase and anti-cancer activities which warrant further purification and identification.

Keywords: Cytotoxicity, kinase, Mallotus mollissimus, phosphatase, Solanum erianthum.