Benthaminin 3, a Novel Antibacterial Cassane-Type Furanoditerpenoid from Caesalpinia benthamiana – Pages 20-25

Benthaminin 3, a Novel Antibacterial Cassane-Type Furanoditerpenoid from Caesalpinia benthamiana – Pages20-25
Rita A. Dickson1, Kofi Annan1, Theophilus C. Fleischer1 and Peter J. Houghton2
1Pharmacognosy Department, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Ghana; 2Pharmacognosy Research Laboratories, Pharmaceutical Sciences Research Division, King’s College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK
DOI: http://dx.doi.org/10.6000/1927-5951.2012.02.01.3

Abstract: The roots of Caesalpinia benthamiana (synonymMezoneuron benthamianum)are considered to be an effective remedy in Ghana for the management of skin diseases and wounds. Bioactivity-guided fractionation of the chloroform extract of the root bark of the plant has resulted in the isolation of a novel cassane-type furanoditerpenoid, designated as benthaminin 3. The structure of the compound was elucidated by the use of spectroscopic techniques. The antibacterial activity of the compound has been assessed using the microdilution assay method. The lowest MIC (63μg/mL) was recorded against Staphylococcus aureus andBacillus subtilis. The compound wasalso observed to have a mild inhibitory effect against resistant strains of bacteria including methicillin-resistant S. aureus, tetracyline-resistant S. aureus and erythromycin-resistant S. aureus with MIC values greater than 1000μg/mL.

Keywords: Caesalpinia benthamiana (Baill.) Herend. and Zarucchi, Mezoneuron benthamianum Baill, Caesalpinaceae, Cassane-type furanoditerpenoids, Antibacterial activities.