Quercetin Enhances Endurance Capacity via Antioxidant Activity and Size of Muscle Fibre Type 1 – Pages 160-164

Quercetin Enhances Endurance Capacity via Antioxidant Activity and Size of Muscle Fibre Type 1 – Pages 160-164
N. Leelayuwat1,5, S. Laddawan2, Y. Kanpetta3,5, M. Benja3, D. Wongpan1,5, O. Tunkamnerdthai1,5, J. Wattanathorn1,5, S. Muchimapura1,5 and J. Yamauchi6,7
1Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; 2Department of Physical Therapy, Naresuan University Phayao Campus, Phayao, Thailand; 3Queen Sirikit Heart Center of The Northeast, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; 4Graduate School, Khon Kaen University, Khon Kaen, Thailand; 5Exercise and Sport Sciences Development and Research Group, Khon Kaen University, Khon Kaen, Thailand; 6Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan; 7Future Institute for Sport Sciences, Tokyo, Japan
DOI: http://dx.doi.org/10.6000/1927-5951.2012.02.02.7

Abstract: This study aimed to examine effects of quercetin on 1) endurance capacity 2) malondialdehyde (MDA) and superoxide dismutase (SOD) activity in skeletal muscle and 3) muscle fibre density and size in mice after an intense exercise. There were 5 groups: control, vitamin C (250 mg/kg body weight), quercetin 150, 300, and 450 mg/kg body weight respectively once a day for 28 days. Endurance capacity was measured by exhaustive swimming exercise test which was done 24-h after swimming at high intensity. Then muscles were analyzed for MDA, SOD activity, and muscle fibre density and size. After the 28-day treatment, endurance time in vitamin C and quercetin treated groups at dose of 150 mg/kg body weight were longer than the vehicle group (p<0.05). MDA concentration in extensor digitorum longus muscle was lower than vehicle group in vitamin C, Q150 and Q450 groups and in soleus muscle the highest was in Q300 group. SOD activity in soleus muscle in Q150 group was higher than vitamin C and Q450 groups. Significant increase in cell diameter of soleus muscle was found (p<0.05). Current findings suggest that ingestion of quercetin can improve endurance capacity, due probably to increased antioxidant activity and size of muscle fibre type 1.

Keywords: Quercetin, oxidative stress, time to exhaustion, slow twitch muscle fibre.