The Effects of Consumption L-Arabinose on Metabolic Syndrome in Humans – Pages 116-126

The Effects of Consumption L-Arabinose on Metabolic Syndrome in Humans- Pages 116-126
Ziming Yang1, Dianpeng Li1, Haiying Jiang1, Guiyun Qian2, Weiguo Sui3, Guimian Zou3 and Hourui Zhang1
1Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Chinese Academy of Sciences. No. 85 Yanshan Road, Yanshan District, Guilin, 541006, China; 2The Second People’s Hospital of Guangxi Zhuang Autonomous Rcglon. No. 1 Xinqioayuan Road, Guilin, 541006, China; 3181st Hospital of Chinese People’s Liberation Army, No. 46 Chongxin Road, Guilin, 541006, China
DOI: http://dx.doi.org/10.6000/1927-5951.2013.03.02.2

Abstract: On the basis of results in rat, L-arabinose decreased total cholesterol (TC), triglycerides (TG), fasting glucose, systolic blood pressure, increased high-density lipoprotein cholesterol (HDLC), and enhanced the glucose tolerance. The primary purposes of the present study was to determine the effects of consumption L-arabinose on metabolic syndrome in humans.All volunteers received L-Arabinose by dissolving it in water. The volunteers didn’t change the diet habits and lifestyles during the whole experiment. The trial lasted for 6 months, and experimental indicators were assayed every two months, which including weight, waist circumference, blood pressure, TG, TC, HDLC, low-density lipoprotein cholesterol (LDLC), fasting plasma glucose, erum uric acid, serum creatinine (Scr), bloodurea nitrogen (BUN), alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Our results showed that the L-arabinose decreased waist circumference, TC, fasting glucose, serum uric acid, ALT and slightly increased HDLCand slightly decreased diastolic blood pressure after 6 months. A tendency for decreased waist circumference, TC, fasting glucose, serum uric acid, ALT after 2, 4 and 6 months of treatment with L-arabinose was observed. In addition, L-arabinose decreased TC, LDLC and body weight. No effects on Scr, BUN, AST. In conclusionsL-arabinosewould reduce most the metabolic syndrome risk factors(decreased circumference, TC, fasting glucose, and so on), and treat the metabolic syndrome as a whole.The present study would provides strong evidence that long-term received L-arabinose would be manage metabolic syndrome.

Keywords: L-arabinose, metabolic syndrome, triglycerides,ALT, waist circumference.