Inhibitory Effects of Chaga (Inonotus Obliquus) on Tumor Promotion in Two-Stage Mouse Skin Carcinogenesis – Pages 71-76

Inhibitory Effects of Chaga (Inonotus Obliquus) on Tumor Promotion in Two-Stage Mouse Skin Carcinogenesis
Pages 71-76
Ayako Akita, Yi Sun and Ken Yasukawa
DOI: http://dx.doi.org/10.6000/1927-5951.2015.05.01.11
Published: 16 February 2015

Abstract: The methanol extract of chaga (sclerotia of Inonotus obliquus) inhibited the promoting effect of 12-O-tetradecanoylphorbol-13-acatate (TPA) applied twice weekly on skin tumor formation in mice initiated with 7,12-dimethylbenz [a] anthracene. The methanol extract from chaga led to the isolation of eight triterpenoids (18). The anti-inflammatory activity of the isolated lanostane-type triterpenes was evaluated against TPA-induced inflammatory ear edema in mice. These compounds showed markedly anti-inflammatory effects, with a 50% inhibitory dose of 125-458 nmol/ear.

Keywords: Chaga, Inonotus obliquus, lanostane-type triterpene, antitumor promotion, anti-inflammation, two-stage carcinogenesis.