Methylsulfonylmethane (MSM) as a New Target for the Treatment of Glycerol-Induced Nephropathy – Pages 137-143

Methylsulfonylmethane (MSM) as a New Target for the Treatment of Glycerol-Induced Nephropathy

Pages 137-143

Shaza Anwar Al Laham

Department of Pharmacology & Toxicology, Faculty of Pharmacy, Damascus University, Syria

DOI: https://doi.org/10.6000/1927-5951.2018.08.03.8

Abstract: Objective: Methylsulfonylmethane (MSM) is a naturally occurring nutrient composed of sulfur, oxygen and methyl groups. MSM may have anti-inflammatory and free radical scavenging activity. The present work was done to investigate the possible cure effect of methylsulfonylmethane on glycerol-induced acute renal failure (ARF) in rats.

Methodes: After water deprivation, a kidney injury was induced in rats by intramuscular administration of glycerol 10 mL/kg (50% vol./vol. in saline). Several parameters including macroscopic score, histopathological and biochemical were determined to assess the degree of treatment.

Results: Results showed that MSM decreased macroscopic and microscopic kidney’s injury scores caused by glycerol. MSM also significantly reduced urea and creatinine levels compared to glycerol-induced ARF group.

Conclusion: MSM as a natural product has a curing effect against glycerol-induced myoglobinuria.

Keywords: Methylsulfonylmethane (MSM), Acute renal failure, Myoglobinuria.