Effects of Buchholzia coriacea Seed on Nutrient Utilization and Serum Biochemical Parameters in Alloxan-Induced Diabetic Rat – Pages 192-198

Effects of Buchholzia coriacea Seed on Nutrient Utilization and Serum Biochemical Parameters in Alloxan-Induced Diabetic Rat

Pages 192-198

Nuria C. Amaechi1, Philippa C. Ojimelukwe2 and Samuel O. Onoja3

1Department of Food Science and Technology, Abia State University, Umuahia Campus, Abia State Nigeria; 2Department of Food Science and Technology, Michael Okpara University of Agriculture, Umudike PMB 7267, Umuahia, Abia State Nigeria; 3Department of Veterinary Physiology and Pharmacology, Michael Okpara University of Agriculture Umudike, PMB 7267, Umuahia, Abia State Nigeria

DOI: https://doi.org/120.29169/1927-5951.2018.08.04.6

Abstract: The effects of Buchholzia coriacea seed on the nutrient utilization and biochemical parameters in alloxan-induced diabetic rat were evaluated. Buchholzia coriacea (BC) seed was washed, sliced, dried, pulverized and mixed with standard ration at 2.5%, 5%, 10% and 20%. The proximate nutrient composition of the standard and prepared rations was determined. The Buchholzia coriacea incorporated rations and standard ration were fed to alloxan-induced diabetic rats for 70 consecutive days. The nutrient utilization and biochemical parameters as well as the histopathology of pancreas of the treated rats were evaluated. The Buchholzia coriacea at 2.5% inclusion rate significantly (p < 0.05) improved the nutrient utilization and biochemical parameters that were compromised in diabetic rats fed with standard ration alone. The B. coriacea also reversed the pancreatic islet damage induced by alloxan. Buchholzia coriacea have potent antidiabetic and hypolipidemic activities and should not be incorporation in excess of 5% in the diet.

Keywords: Apparent digestibility, biological value, hypolipidemia, gas chromatography, glycosylated hemoglobin.