Investigation of the Role of Serum Matrix Gla-Protein as a Biomarker of Calcific Aortic Valve Disease – Pages 152-156

Investigation of the Role of Serum Matrix Gla-Protein as a Biomarker of Calcific Aortic Valve Disease

Amal Al Nawasreh1, Hussam Shebli2 and Sahar Fahoum1

1Department of Biochemistry and Microbiology, Faculty of Pharmacy, Damascus University, Damascus, Syria; 2Department of Internal Medicine, Cardiovascular Disease Section, Faculty of Medicine, Damascus University, Damascus, Syria

DOI: https://doi.org/120.29169/1927-5951.2019.09.03.3

Abstract: Background: Calcific aortic valve disease (CAVD) is a major contributor to cardiovascular morbidity and mortality. Circulating total uncarboxylated Matrix γ-carboxyglutamate (Gla) protein (t-ucMGP) is a promising biomarker for rapid screening of subjects prone to cardiovascular calcification who may need more invasive vascular diagnostics. Preliminary data show that low t-ucMGP levels are indicative for prevalent vascular calcification. Hence, the aim of our study was to investigate the possible role of circulating t-ucMGP as a biomarker may help in identification patients with CAVD, taking into consideration that CAVD is a form of vascular calcification.

Methods & Materials: We analyzed serum t-ucMGP levels by enzyme-linked immunosorbent assay (ELISA) in 50 patients with echocardiographically proven CAVD and 21 control subjects.

Results: Serum t-ucMGP levels were significantly lower in patients with CAVD (29.29±12.18 nmol/l) compared to the control group (36.84±21.79 nmol/l, p = 0.003).

Conclusion: Serum t-ucMGP may help as a noninvasive biomarker for identification of these patients.

Keywords: Calcific aortic valve disease (CAVD), serum biomarker, screening, ELISA, uncarboxylated matrix Gla-protein (ucMGP).