Azithromycin-Chitosan Films for Improved Haemostasis and Wound Healing – Pages 305-315

Azithromycin-Chitosan Films for Improved Haemostasis and Wound Healing

Pages 305-315

Linda Fateh1,2, Susan Waiss2 and Mohammad Othman1

1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Damascus University, Syria; 2Scientific Studies and Research Centre, Damascus, Syria

DOI: https://doi.org/10.29169/1927-5951.2019.09.06.3

Abstract: Wound healing is a global medical concern, because haemorrhage is still a major cause of morbidity and mortality. Therefore, more effective and cost-effective dressings are required. Antimicrobial dressing of Azithromycin (AZM) (a broad-spectrum macrolide antibiotic) with Chitosan (CS) as a carrier, has a lot of desired properties such as haemostatic, pain-reducing, and less scar forming. It is prepared by a solvent evaporation method. The film morphology is investigated by SEM and film-water wettability is measured by a contact angle method. The drug-polymer interactions are evaluated by using FTIR and DSC. Azithromycin loaded films (different mass ratio of AZM to CS w % 10%, 25% and 50%) were sterilized by Gamma radiation, then their antimicrobial characteristics and haemostatic performance were evaluated. Film thickness was about 9 µm. The wettability properties of films were enhanced by adding AZM and PEG6000 5% (mass ratio of PEG 6000 to CS w %). Microbial growth inhibitions were identified for films loaded with Azithromycin.

Keywords: Azithromycin AZM, Chitosan CS, wound healing, haemostatic, film.