Reduction of Pain and Depression in Occlusal Splint-Based Treatment for TMD is Accompanied with Increase in Urinary Serotonin


  • M.B. Nunes Lusophone University, Lisbon, Portugal
  • J. Oliveira Lusophone University, Lisbon, Portugal
  • R. Brito Lusophone University, Lisbon, Portugal



 TMD, Occlusal splint, Urinary Serotonin, Depression, Pain.


The aim of this study was to assess the parallel effects of an occlusal splint-based intervention for TMD on urinary serotonin levels, depression and pain. Previous RCT studies have shown that occlusal splint-based treatment reduce pain and depression, but have not measured serotonin. 15 patients (four males and 11 females) completed an intervention protocol with a silicone dental splint for 60 days. Patients were assessed before and after treatment for urinary serotonin levels, TMD-related pain and depression symptoms (self-reports). Results showed a significant increase in urinary serotonin levels between the two assessments along with a reduction in pain and depression. Overall results suggest that the positive effects of occlusal-based treatment on physical and mental health could be related to increases in serotonin levels.


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How to Cite

M.B. Nunes, J. Oliveira, & R. Brito. (2014). Reduction of Pain and Depression in Occlusal Splint-Based Treatment for TMD is Accompanied with Increase in Urinary Serotonin. Journal of Basic & Applied Sciences, 10, 183–188.



Medical Sciences