The Membrane Sensors Sensitive to Fluoxetine - Optimization of the Analytical Parameters


 Ion-selective electrode, potentiometric titration, drug analysis, fluoxetine hydrochloride.

How to Cite

Joanna Drozd. (2015). The Membrane Sensors Sensitive to Fluoxetine - Optimization of the Analytical Parameters. Journal of Basic & Applied Sciences, 11, 397–402.


Background: The analytical characteristics of electrodes containing liquid PVC membrane depend on the purity of the electroactive material and the applied membrane solvents.
Methods: Fluoxetine - one H-bond donor, formed ion-associated complexes with tetraphenylborate, tetrakis(4-chlorophenyl)borate and dipicrylamine. To confirm the quality and purity obtained complexes the elemental and TLC analysis were performed. The construction and general characteristics of fluoxetine ion-selective plastic membrane sensors, based on the use of a fluoxetine – tetrakis(4-chlorophenyl)borate ion-pair complex as electroactive material with 2-nitrophenyloctyl ether, bis(2-ethylhexyl)sebacate, bis(2-butylpentyl)adipate and 1-isopropyl-4-nitrobenzene as solvent mediators.
Results: The electrode containing Fl-ClTPB-NPhOE (fluoxetine-tetrakis(4-chlorophenyl)borate-2-nitrophenyloctyl ether showed a linear response to fluoxetine at concentration ranges of 30.93 – 2.16 g·L-1 with a super Nernstian cationic slope 60.19 mV·decade-1.
Conclusions: This Fl-ClTPB-NPhOE sensor was used for the potentiometric determination of the content of fluoxetine hydrochloride in pure form and pharmaceutical formula.


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