Synthesis of Mannich Bases of 8-Hydroxyquinoline

Authors

  • Humaira Siddiqi University of Karachi, Karachi, Pakistan
  • Shaheen Faizi University of Karachi, Karachi, Pakistan
  • Shaista Naz University of Karachi, Karachi, Pakistan
  • Erum Zahir University of Karachi, Karachi, Pakistan

DOI:

https://doi.org/10.6000/1927-5129.2015.11.71

Keywords:

 8-Hydroxyquinoline, Oxine, Mannich Base, Mannich Reaction.

Abstract

In search of new potential therapeutic agents, 8-Hydroxyquinoline which is a highly active antifungal and antibacterial agent was subjected to Mannich reaction. Different combinations of aromatic aldehyde and aromatic amines were used for Mannich reaction on 8-Hydroxyquinoline from which one new 7-[α-(anilino)-3',4'-dimethoxybenzyl]-8-hydroxyquinoline (3) and two known Mannich bases (1,2) were obtained.

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Published

2015-01-05

How to Cite

Humaira Siddiqi, Shaheen Faizi, Shaista Naz, & Erum Zahir. (2015). Synthesis of Mannich Bases of 8-Hydroxyquinoline. Journal of Basic & Applied Sciences, 11, 539–543. https://doi.org/10.6000/1927-5129.2015.11.71

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Section

Chemistry