Anti-Nematodal Efficacy of Ivermectin (Oral) and Extracts of Coriandrum sativum in Sheep in Barani Livestock Production Research Institute (BLPRI) Kherimurat, District Attak Punjab Pakistan

Authors

  • Memrez Khushal Gigyani Veterinary Research Institute Peshawar, Pakistan
  • Khurshaid Anwar Veterinary Research and Disease Investigation Center Balogram Swat, Pakistan
  • Muhammad Ovais Omer University of Veterinary and Animal Sciences Lahore, Pakistan
  • Habibun Nabi Veterinary Research and Disease Investigation Center Balogram Swat, Pakistan
  • Insanud Din Veterinary Research and Disease Investigation Center Balogram Swat, Pakistan
  • Anwarud Din PhD Scholar Sun Yat-sen University, China
  • Zill E. Huma University of Peshawar, Pakistan

DOI:

https://doi.org/10.6000/1927-5129.2018.14.12

Keywords:

Anti-nematodal efficacy, Ivermectin, Coriandrumsativum, sheep, Punjab.

Abstract

Anthelmentic resistance (AR) is one of the major problems of livestock industry in developing countries. Using indigenous medicinal plants may be an alternate way to overcome this problem. Total 60 sheep nematode positive were selected and divided into 6 groups having 10 sheep each. Group A as un-treated control, group B was given Ivermectin at the dose rate of 0.2mg/kg body weight Group C and Group D was given the Chloroformic extract while Group E and F was given the Methalonic extract of Coriandrum sativum whole plant at the dose rate of 50 mg/kg and 100 mg/kg body weight respectively. After treatments, fecal eggs count reduction test (FECRT) (eggs/g) was carried out on day 7, 14 and 28. The EPG in untreated group at day 28 was increased 21.6%. Significant decrease in EPG was only observed at day 28 in Ivermectin treated group (92.6%) and Methanolic extract at a dose rate of 100 mg/kg body weight (60.69%). No significant results were recorded in remaining groups. It was concluded that 100 mg/kg body weight Methalonic extract of Coriandrum sativum would be a best alternative as anti-nematodal drug.

References

Akhtar MS, Iqbal Z, Khan MN, Lateef M. Anthelmintic activity of medicinal plants with particular reference to their use in animals in the Indo–Pakistan subcontinent. Small Ruminant Res 2000; 38(2): 99-107. https://doi.org/10.1016/S0921-4488(00)00163-2

Maritorena-Diez S, Roa-Vásquez S, Marín-Mejía B, Alonso-Díaz M, Rodríguez-Vivas R. Efficacy of moxidectin 0.5% pour-on against naturally acquired nematode infections in cattle in the Mexican tropics. Vet Parasitol 2005; 134: 117-120. https://doi.org/10.1016/j.vetpar.2005.06.024

Geary TG, Hosking BC, Skuce PJ, von Samson-Himmelstjerna G, Maeder S, Holdsworth P, Pomroy W, Vercruysse J. World Association for the Advancement of Veterinary Parasitology (WAAVP) Guideline: Anthelmintic combination products targeting nematode infections of ruminants and horses. Vet Parasitol 2012; 190(1): 306-316. https://doi.org/10.1016/j.vetpar.2012.09.004

Hidalgo-Argüello M, D??ez-Baños N, Rojo-Vázquez F. Efficacy of moxidectin 1% injectable and 0.2% oral drench against natural infection by Dictyocaulusfilaria in sheep. Vet Parasitol 2002; 107(1): 95-101. https://doi.org/10.1016/S0304-4017(02)00116-4

Entrocasso C, Alvarez L, Manazza J, Lifschitz A, Borda B, Virkel G, Mottier L, Lanusse C. Clinical efficacy assessment of the albendazole–ivermectin combination in lambs parasitized with resistant nematodes. Vet Parasitol 2008; 155(3–4): 249-256. https://doi.org/10.1016/j.vetpar.2008.04.015

Taylor S, Le Stang J, Kenny J. Persistent efficacy of doramectin and moxidectin against Cooperiaoncophor infections in cattle. Vet Parasitol 2001; 96(4): 323-328. https://doi.org/10.1016/S0304-4017(01)00382-X

Tariq K, Chishti M, Ahmad F, Shawl A. Epidemiology of gastrointestinal nematodes of sheep managed under traditional husbandry system in Kashmir valley. Vet Parasitol 2008; 15(1): 138-143. https://doi.org/10.1016/j.vetpar.2008.06.013

Pathak NL, Kasture SB, Bhatt NM, Patel RG. Experimental modeling of anxiety 2011; 64(4): 439-445.

Obame LCE, Timoleon AB, Privat OJ, Ludovic M, Roger NAG, Fatouma AL, Nestor IH. Total Phenolic Composition, Antibacterial and Antioxidant Activities of FagaraheitziiAubr & Pellegr Medicinal Plant of Gabon. Vidic Res Int 2013; 1: 2330-0280.

Bimakr M, Rahman RA, Taip FS, Ganjloo A, Salleh LM, Selamat J, Hamid A, Zaidul I. Comparison of different extraction methods for the extraction of major bioactive flavonoid compounds from spearmint (Menthaspicata) leaves. Food Bioprod Process 2011; 89(1): 67-72. https://doi.org/10.1016/j.fbp.2010.03.002

Hounzangbe-Adote S, Fouraste I, Moutairou K, Hoste H. In vitro effects of four tropical plants on three life-cycle stages of the parasitic nematode Haemonchus contortus. Res Vet Sci 2005; 78: 155-160. https://doi.org/10.1016/j.rvsc.2004.05.009

Geary TG, Sangster NC, Thompson DP. Frontiers in anthelmintic pharmacology. Vet Parasitol 1999; 84: 275-295. https://doi.org/10.1016/S0304-4017(99)00042-4

Debella A. Manual for Phytochemical Screening of Medicinal Plants. Ethiopian health and Nutrition Research Institute, Addis Ababa, Ethiopia 2002.

Iqbal Z, Lateef M, Ashraf M, Jabbar A. Anthelmintic activity of Artemisia brevifoliain sheep. J Ethnopharmacol 2004; 93: 265-268. https://doi.org/10.1016/j.jep.2004.03.046

Athanasiadou S, Kyrazakis I, Jakson F, Coop RL. Direct anthelminthic effects of condensed tannins towards different gastrointestinal nematodes of sheep: in vitro and in vivo studies. Vet Parasitol 2001; 99: 205-219. https://doi.org/10.1016/S0304-4017(01)00467-8

Prichard PK, Hennessy DR, Steel JW. Prolonged administration: a new concept for increasing the spectrum of and effectiveness of anthelmintics. Vet Parasitol 1978; 4: 309-315. https://doi.org/10.1016/0304-4017(78)90017-1

Downloads

Published

2018-01-05

How to Cite

Memrez Khushal Gigyani, Khurshaid Anwar, Muhammad Ovais Omer, Habibun Nabi, Insanud Din, Anwarud Din, & Zill E. Huma. (2018). Anti-Nematodal Efficacy of Ivermectin (Oral) and Extracts of Coriandrum sativum in Sheep in Barani Livestock Production Research Institute (BLPRI) Kherimurat, District Attak Punjab Pakistan. Journal of Basic & Applied Sciences, 14, 87–91. https://doi.org/10.6000/1927-5129.2018.14.12

Issue

Section

Veterinary Sciences