Evaluation of the Antibacterial and Wound Healing Activity of Quercus persica


  • Ebrahimi Akram Department of Biology, Faculty of Sciences, Urmia University, Urmia, Iran
  • Khayami Masoud Department of Biology, Faculty of Sciences, Urmia University, Urmia, Iran
  • Nejati Vahid Department of Biology, Faculty of Sciences, Urmia University, Urmia, Iran




Qurcus persica, Antibacterial, Extract, Wound healing


Quercus persica is one of the four species oak that growing in the zagrossian region in Iran. This plant contains different components of therapeutic value. In this investigation, antibacterial and wound healing effects of methanolic extract of fruits of Quercus persica has been studied. Milled oak fruit that their hull was separated, was extracted with methanol in Soxhleťs apparatus .The effect of extract in three concentration (25,50,75mg/ml) were tested using agar diffusion method on Staphylococcus aureus ATCC 25923, Staphylococcus epidermidis RTCC 1898 and Escherichia coli O157:H7 and in form topical administration on excision wound in rats.Results showed that all of concentrations were effective on inhibition of bacteria, but this effect with 50 and 75 mg/ml concentration of extract was significant for bacteria. Also in comparison with tested antibiotics, the effect of 75 mg/ml concentration of extract was similar or higher than them. Also in the extract-treated wounds indicated that epithelialize faster, and the rate of wound contraction was significantly increased in comparison to control wounds. This results suggest that Quercus persica possesses compounds with antibacterial and wound healing properties


Berahou A, Auhmani A, Fdil N, Benharref A, Jana M, Gadhi CA. Antibacterial activity of Quercus ilex bark’s extracts. J Ethnopharmacol 2007; 112: 426-9. http://dx.doi.org/10.1016/j.jep.2007.03.032 [2] Khosravi AD, Behzadi A. Evaluation of The antibacterial activity of the seed hull of Quercus brantii on some gram negative bacteria. Pak J Med Sci 2006; 22: 429-32. [3] Shetty S, Udupa S, Udupa L. Evaluation of antioxidant and wound healing effects of alcoholic and aqueous extract of Ocimum sanctum Linn in rats. eCAM 2007; pp. 1-7. [4] Nayak BSh. Cecropia peltata L (Cecropiaceae) has woundhealing potential: A preclinical study in a sprague dawley rat model. Int J Low Extrem Wounds 2006; 5: 20-6. http://dx.doi.org/10.1177/1534734606286472 [5] Sabeti HF. Trees and shrubs of Iran. 3rd ed. Yazd University Press. Yazd 2003; pp. 576. [6] Saffarzadeh A, Vincze L, Csapó J. Determination of the chemical composition of acorn (Quercus brantii), Pistacia atlantica and Pistacia khinjuk seeds as non-conventional feedstuffs. Acta Agr Kapos 1999; 3: 59-69. [7] Hosseini P. Conservation of biodiversity in the central zagros landscape conservation zone (PIMS 2278). Government of the Islamic Republic of Iran. UNDP GEF 2005; pp. 35. [8] Shahidi BGH, Aghighi S, Karimi NA. Antibacterial and antifungal survey in plants used in indigenous herbalmedicine of South East regions of Iran. J Biol Sci 2004; 4: 405-12. http://dx.doi.org/10.3923/jbs.2004.405.412 [9] Umachigia SP, Jayaveerab KN, Ashok KCK, Kumard GS, Vrushabendra SBM, Kishore KDV. Studies on wound healing properties of Quercus infectoria. Trop J Pharm Res 2008; 7: 913-9 [10] Haidari R, Siami A, Pakbaz M, Aghazadeh M. Measurement of tannin in four genotype of Quercus infectoria olive and application of their gall powder in treatment of wound. J Aro Med Pla Res Iran 2005; 21: 433-43. [11] Malekinejade H. Identification and collection of Quercus infectoria galls and histological study of wound healing by powderes forms. Fac Agri Uni Urm 1996. [12] Kumara SHM, Krishna V, Shankarmurthy K, Abdul RB, Mankani KL, Mahadevan KM, et al. Wound healing activity of embelin isolated from the ethanol extract of leaves of Embelia ribes Burm. J Ethnopharmacol 2007; 109: 529-34. http://dx.doi.org/10.1016/j.jep.2006.09.003 [13] Hayouni EA, Abedrabba M, Bouix M, Hamdi M. The effects of solvents and extraction method on the phenolic contents and biological activities in vitro of Tunisian Quercus coccifera L. and Juniperus phoenicea L. fruit extracts. Food Chem 2007; 105:1126-34. http://dx.doi.org/10.1016/j.foodchem.2007.02.010 [14] Cowan MM. Plant products as antimicrobial agents. Clin Microbio. Rev 1999; 12: 64-582. [15] Jahanshahi GH, Moattar F, Soltani MR. Evaluation of a herbal medicine in the treatment of recurrent aphthous ulcer. Beheshti Univ Dent J. 2004; 22: 19-25. [16] Lopes GC, Sanches ACC, Nakamura CV, Dias FBP, Hernandes L, de Mello JCP. Influence of extracts of Stryphnodendron polyphyllum Mart and Stryphnodendron obovatum Benth. On the cicatrisation of cutaneous wounds in rats. J Ethnopharmacol 2005; 99: 265-72. http://dx.doi.org/10.1016/j.jep.2005.02.019 [17] Teimouri M, Korori S, Moraghebi F, Matinizadeh M. Comparison antibacterial activity of Quercus persica and Quercus ilex. Iranian J Pharm Res 2004; 3:76-7. [18] Kiarostami kh. Evaluation of antibacterial effects of Quercus persica and Quercus castaneifolia in tissue culture and perfect plant. J Sci 1998; 11: 1-8.




How to Cite

Akram, E., Masoud, K., & Vahid, N. (2012). Evaluation of the Antibacterial and Wound Healing Activity of Quercus persica. Journal of Basic & Applied Sciences, 8(1), 118–123. https://doi.org/10.6000/1927‐5129.2012.08.01.18