Quantum Therapy: A New Way in Osteoporosis Primary Prevention and Treatment


  • Sergio Stagnaro Honorary President of SISBQ, International Society of Quantum Biophysical Semeiotics, CP 18, 31020 Lancenigo, Via Erasmo Piaggio, 23/8 – Riva Trigoso – Genova, Italy
  • Simone Caramel President of SISBQ, International Society of Quantum Biophysical Semeiotics, CP 18, 31020 Lancenigo, Via Doberdò, 3 – 31020 Fontane di Villorba – Treviso, Italy




Osteoporosis, primary prevention, semeiotics, quantum therapy


The paper highlights the role played by quantum therapy in Osteoporosis Primary Prevention and treatment. We provide an overview of other useful treatments in Osteoporosis prevention such as CoQ10, Melatonin and Mediterranean Diet comparing their efficacy to that offered by the quantum therapy. This is done through ‘Quantum Biophysical Semeiotics’ bed-side evaluation, monitoring the results and efficiency of ongoing therapies aimed at improving mitochondrial and endothelial function, when it is unpaired in any biological systems.

'Quantum Biophysical Semeiotics’ theory is an extension of medical semeiotics. It is grounded on a multidisciplinary approach that involves chemistry and biology, genetics and neuroscience, chaos theory and quantum physics. It is based on the method of ‘Auscultatory Percussion’, through which by means of the common stethoscope, it is possible to listen to the signs that the body gives us when appropriately stimulated. The stimuli are used to induce consistent behaviour -typical of dissipative systems far from equilibrium, according to Prigogine - in precise and well defined biological systems of the human body, thus giving local qualitative information on the state of health or disease, whether potential, being developed but not yet evident by usual clinical trial, effective or even in chronic phase.

The 'Quantum Biophysical Semeiotics’ theory provides very detailed case studies based on the latency time, duration, and intensity of the reflexes, which play a central role in such a diagnostic method.


Stagnaro S, Caramel S. The role of Mediterranean diet, CoQ10 and conjugated-melatonin in Osteoporosis primary prevention and therapy. CNF Sci Bentham 2012; 8: 55-62.

Stagnaro S. Istangiopatia Congenita Acidosica Enzimo-Metabolica. Una patologia mitocondriale ignorata. Gazz Med It Arch Sci Med 1985; 144: 423.

Stagnaro S. Rivalutazione e nuovi sviluppi di un fondamentale metodo diagnostico: la percussione ascoltata. Atti Accademia Ligure di Scienze e Lettere 1978; Vol. XXXIV.

Stagnaro S. ‘Reale Rischio’ semeiotico biofisico. I ‘Dispositivi Endoarteriolari di Blocco’ neoformati, patologici, tipo I, sottotipo a) oncologico, e b) aspecifico. Ed. Travel Factory, Roma, 2009.

Stagnaro S, Stagnaro-Neri M. Le ‘Costituzioni Semeiotico-Biofisiche’. Strumento clinico fondamentale per la prevenzione primaria e la definizione della ‘Single Patient Based Medicine’. Ed. Travel Factory, Roma, 2004.

Caramel S, Stagnaro S. The role of mitochondria and mit-DNA in oncogenesis. Quantum Biosyst 2010; 2(1): 250-81.

Stagnaro S, Stagnaro-Neri M. Introduzione alla ‘Semeiotica Biofisica’. Il ‘Terreno Oncologico’. Ed. Travel Factory, Roma, 2004.

Curri SB. Le microangiopatie. Inverni della Beffa, Milano, 1986.

Bucciante L. Anastomosi arterovenose e dispositivi regolatori del flusso sanguigno. Mon zool it Suppl 1949; 57: 3-10.

Pratesi F. Microcircolazione e microangiologia. Fisiopatologia, clinica e terapia. Ediz. Minerva Medica, Torino, 1990.

Goldberger AL, West BJ. Applications of non-linear dynamics to clinical cardiology. ANN NY Acad Sci 1987; 504: 195. http://dx.doi.org/10.1111/j.1749-6632.1987.tb48733.x

Stagnaro S, Stagnaro-Neri M. Deterministic chaotic biological system: the microcirculatory bed. Gazz Med It-Arch Sci Med 1994; 153: 99.

Stagnaro S. Role of Coronary ‘Endoarteriolar Blocking Devices’ in myocardial preconditioning - c007i. Lecture, V Virtual International Congress of Cardiology 2007; Available at: http://www.fac.org.ar/qcvc/llave/c007i/stagnaros.php

Hammersen F. Zur ultrastruktur der arterio-veno¨sen anastomosen. In: Hammersen F, Gross D, Eds. Die Arterio-venoesen Anastomosen Anatomie, Physiologie, Pathologie, Klinik. Verlag Hans Hubert: Bern und Stuttgart 1968; pp. 24-37.

Stagnaro-Neri M, Stagnaro S. Auscultatory percussion evaluation of ‘Arterio-Venous Anastomoses’ dysfunction in early Arteriosclerosis. Acta Med Medit 1989; 5: 141-44.

Stagnaro-Neri M, Stagnaro S. Diagnosi clinica precoce dell’Osteoporosi con la ‘Percussione Ascoltata’. Clin Ter 1991; 137: 21-27. ?Medline?.

Stagnaro S. Bedside diagnosis of osteoporotic constitution, real risk of inheriting osteoporosis, and finally osteoporosis. Theoretical Biology and Medical Modelling, 2007; 21 June. Available at: http://www.tbiomed.com/content/4/1/23/comments#285569

Caramel S. Coronary Artery Disease and Inherited Real Risk of CAD, JOQBS, 2010. Available at: http://www.sisbq.org/uploads/5/6/8/7/5687930/cad_caramel.pdf

Society of Obstetricians and Gynaecologists of Canada. The Canadian consensus conference on Menopause and Osteoporosis, 2002 update [SOGC guideline no 108

Stagnaro-Neri M, Stagnaro S. Acidi grassi ?-3, scavengers dei radicali liberi e attivatori del ciclo Q della sintesi del CoQ10. Gazz Med It–Arch Sci Med 1992; 151: 341-45.

Lenaz G, Parenti Castelli G. Multiple roles of ubiquinone in mammalians cells. Drugs Exptl Clin Res 1984; 10: 481-85.

Lubich T, Bargossi AM, Fiorella PL. Metabolic effects of coenzyme Q treatment in high level athletes. VI Simposio Internazionale su: Biomedical and clinical aspects of coenzyme Q. Chairmen: Folkers K, Littarru GP, Yamagamy Y. 22-24 gennaio 1990, Roma. Abstracts, 70.

Stagnaro S, Stagnaro-Neri M. Carenza di CoQ10 secondaria a terapia ipolipidemizzante diagnosticata con la percussione ascoltata. Settimana Italiana di Dietologia. Merano 9-13 aprile 1990. Com Abstract 105 e Epatol 1991; 37: 17-22.

Stagnaro-Neri M, Stagnaro S. ‘Auscultatory Percussion Coenzyme Q’ deficiency syndrome. VI Simposio Internazionale su: Biomedical and clinical aspects of coenzyme Q. Chairmen: Folkers K., Littarru G.P., Yamagamy Y., 22-24 gennaio 1990, Roma. Abstracts, 104.

Stagnaro S. Ipercolesterolemia e Coenzima Q10. Pract Ed It 1990; 133: 5-6.

Stagnaro-Neri M, Stagnaro S. Sindrome clinica percusso-ascoltatoria da carenza di Co Q10. Medic Geriatr 1993; XXIV: 239-51.

Stagnaro S, Stagnaro-Neri M. ‘Single Patient Based Medicine’. La medicina basata sul singolo paziente: Nuove Indicazioni della Melatonina. Ed. Travel Factory, Roma, 2005.

Baker SK, Tarnopolsky MA. Statin myopathies: pathophysiologic and clinical perspectives. Clin Invest Med 2001; 24: 2258-72.

Leung NM, Ooi TC. Use of statins and fibrates in hyperlipidemic patients with neuromuscular disorders. Ann Intern Med 2000; 132: 418-19.

Mitchel P. The vital protonmotive role of Coenzyme Q. VI Simposio Internazionale su: Biomedical and clinical aspects of coenzyme Q. Chairmen: Folkers K., Littarru G.P., Yamagamy Y., 22-24 gennaio 1990, Roma. Abstracts, 77.

Neri Stagnaro M, Stagnaro S. CoQ10 in the prevention and treatment of primary osteoporosis. Preliminary data. Clin Ter 1995; 146(3): 215-9.

Takahashi R. Anti-aging studies on the senescence accelerated mouse (SAM) strains. Yakugaku Zasshi 2010; 130(1): 11-8. http://dx.doi.org/10.1248/yakushi.130.11

Gutierrez-Mariscal FM, Perez-Martinez P, Delgado-Lista J, et al. Mediterranean diet supplemented with coenzyme Q10 induces postprandial changes in p53 in response to oxidative DNA damage in elderly subjects. Age (Dordr) 2012; 34(2): 389-403. http://dx.doi.org/10.1007/s11357-011-9229-1

Ochoa JJ, Pamplona R, Ramirez-Tortosa MC, et al. Age-related changes in brain mitochondrial DNA deletion and oxidative stress are differentially modulated by dietary fat type and coenzyme Q??. Free Radic Biol Med 2011; 50(9): 1053-64. http://dx.doi.org/10.1016/j.freeradbiomed.2011.02.004

Werbach MR. Melatonin for the treatment of gastroesophageal reflux disease. Altern Ther Health Med 2008; 14(4): 54-8.

Suzuki N, Somei M, Seki A, Reiter RJ, Hattori A. Novel bromomelatonin derivatives as potentially effective drugs to treat bone diseases. J Pineal Res 2008; 45(3): 229-34. http://dx.doi.org/10.1111/j.1600-079X.2008.00623.x

Maldonado MD, Pérez-San-Gregorio MA, Reiter RJ. The role of melatonin in the immuno-neuro-psychology of mental disorders. Recent Pat CNS Drug Discov 2009; 4(1): 61-9. http://dx.doi.org/10.2174/157488909787002564

Paternoster L, Radogna F, Accorsi A, Cristina Albertini M, Gualandi G, Ghibelli L. Melatonin as a modulator of apoptosis in B-lymphoma cells. Ann NY Acad Sci 2009; 1171: 345-9. http://dx.doi.org/10.1111/j.1749-6632.2009.04910.x

Cutando A, Aneiros-Fernández J, Aneiros-Cachaza J, Arias-Santiago S. Melatonin and cancer: current knowledge and its application to oral cavity tumours. J Oral Pathol Med 2011; 40(8): 593-7. http://dx.doi.org/10.1111/j.1600-0714.2010.01002.x

Lemoine P, Wade AG, Katz A, Nir T, Zisapel N. Efficacy and safety of prolonged-release melatonin for insomnia in middle-aged and elderly patients with hypertension: a combined analysis of controlled clinical trials. Integr Blood Press Control 2012; 5: 9-17.

Carpentieri A, Díaz de Barboza G, Areco V, Peralta López M, Tolosa de Talamoni N. New perspectives in melatonin uses. Pharmacol Res 2012; [Epub ahead of print

Sanchez-Barcelo EJ, Mediavilla MD, Alonso-Gonzalez C, Rueda N. Breast Cancer Therapy Based on Melatonin. Recent Pat Endocr Metab Immune Drug Discov 2012; [Epub ahead of print

Quinzii CM, Hirano M. Coenzyme Q and mitochondrial disease. Dev Disabil Res Rev 2010; 16(2): 183-8. http://dx.doi.org/10.1002/ddrr.108

López LC, Quinzii CM, Area E, et al. Treatment of CoQ(10) deficient fibroblasts with ubiquinone, CoQ analogs, and vitamin C: time- and compound-dependent effects. PLoS One 2010; 5(7): e11897. http://dx.doi.org/10.1371/journal.pone.0011897

Cordero MD, Alcocer-Gómez E, de Miguel M, et al. Coenzyme Q(10): a novel therapeutic approach for Fibromyalgia? case series with 5 patients. Mitochondrion 2011; 11(4): 623-5. http://dx.doi.org/10.1016/j.mito.2011.03.122

Sourris KC, Harcourt BE, Tang PH, et al. Ubiquinone (coenzyme Q10) prevents renal mitochondrial dysfunction in an experimental model of type 2 diabetes. Free Radic Biol Med 2012; 52(3): 716-23. http://dx.doi.org/10.1016/j.freeradbiomed.2011.11.017

Trichopoulou A. Modified Mediterranean diet and survival: EPIC-elderly prospective cohort study. BMJ 2005; 330: 991 (30 April), doi:10.1136/bmj.38415.644155.8F; published 8 April 2005.

Huijbregts P, Feskens E, Rasanen L, Fidanza F, Nissinen A, Menotti A. Dietary pattern and 20 year mortality in elderly men in Finland, Italy, and the Netherlands: longitudinal cohort study. BMJ 1997; 315: 13-7. http://dx.doi.org/10.1136/bmj.315.7099.13

World Cancer Research Fund and American Institute for Cancer Research. Food, nutrition and the prevention of cancer: a global perspective. Washington DC: WCRF and AICR, 1997.

Knoops KT, de Groot LC, Kromhout D, Perrin AE, Moreiras-Varela O, Menotti A. Mediterranean diet, lifestyle factors, and 10-year mortality in elderly European men and women: the HALE project. JAMA 2004; 292: 1433-9. http://dx.doi.org/10.1001/jama.292.12.1433

Bonaccio M, Iacoviello L, de Gaetano G. On Behalf Of The Moli-Sani Investigators. The Mediterranean diet: The reasons for a success. Thromb Res 2012; 129(3): 401-4.

Demarin V, Lisak M, Morovi? S. Mediterranean diet in healthy lifestyle and prevention of stroke. Acta Clin Croat 2011; 50(1): 67-77.

Salas-Salvadó J, Martinez-González MÁ, Bulló M, Ros E. The role of diet in the prevention of type 2 diabetes. Nutr Metab Cardiovasc Dis 2011; 21(Suppl 2): B32-48. http://dx.doi.org/10.1016/j.numecd.2011.03.009

Stagnaro S. Endothelial cell function can ameliorate under safer drugs, such as Melatonin-Adenosine. BMC Cardiovascular disorders. 2004. Available at: http://www.biomedcentral.com/1471-2261/4/4/comments

Kesemenli C, Necmio?lu S. The role of melatonin as a link between head injury and enhanced osteogenesis. Medical Hypotheses 2003; 65(3), 605-606.

Steinhilber D, Brungs M, Werz O. The nuclear receptor for melatonin represses 5-Lipoxygenase Gene Expression in Human B Lymphocytes. Exper Biol Med 1995; 270(13): 7037-40.

Stagnaro S, Stagnaro-Neri M. La Melatonina nella Terapia del Terreno Oncologico e del “Reale Rischio” Oncologico. Ed. Travel Factory, Roma, 2004.

Stagnaro S. Quantum Biophysical Semeiotics: Recognizing and Treating Osteoporosis, starting from Osteoporosis Inherited Real Risk. JOQBS, 2011. Available at: http://www.sisbq.org/uploads/5/6/8/7/5687930/qbs_osteoporosis.pdf

Ladizesky Marta G, Boggio V, Cutrera RA. Melatonin effect on bone metabolism in rats treated with methylprednisolone. J Pineal Res 2006; 40(4): 297-304(8).

Ostrowska Z, Kos-Kudla B, Nowak M. The relationship between bone metabolism, melatonin and other hormones in sham-operated and pinealectomized rats. Endocr Regulat 2003; 37: 211-24.

Ladizesky MG, Boggio V, Albornoz L. Melatonin increases oestradiol-induced bone formation in ovariectomized rats. J Pineal Res 2003; 34(2): 143-51. http://dx.doi.org/10.1034/j.1600-079X.2003.00021.x

Tamura T, Yoneda M, Yamane K. Serum leptin and adiponectin are positively associated with bone mineral density at the distal radius in patients with type 2 diabetes mellitus. Metabolism 2003; 56(5): 623-28.

Zoico E, Zamboni M, Di Francesco V, Mazzali G, Fantin F. Relation between adiponectin and bone mineral density in elderly post-menopausal women: role of body composition, leptin, insulin resistance, and dehydroepiandrosterone sulfate. J Endocrinol Invest 2008; 31(4): 297-302.

Shinod Y, Yamaguchi M, Ogata N. Regulation of bone formation by adiponectin through autocrine/paracrine and endocrine pathways. J Cell Biochem 2008; 99(1): 196-208.

Lawrence GR. Pathogenesis of osteoporosis: concepts, conflicts, and prospects. Clin Invest 2005 ; 115: 3318-25. doi:10.1172/JCI27071. Available at: http://www.jci.org/cgi/content/full/115/12/3318

Cheung AM, Feig DS, Kapral M, Diaz-Granados N, Dodin S, The Canadian Task Force on Preventive Health Care. Prevention of osteoporosis and osteoporotic fractures in postmenopausal women: recommendation statement from the Canadian Task Force on Preventive Health Care. CMAJ 2004; 170(11). Available at: http://www.cmaj.ca/cgi/content/full/170/11/1665 http://dx.doi.org/10.1503/cmaj.1030757

Stagnaro S. Endothelial cell function can ameliorate under safer drugs, such as Melatonin-Adenosine. BMC Cardiovascular Disorders 2004. Available at: http://www.biomedcentral.com/1471-2261/4/4/comments

Stagnaro S. Il test Semeiotico-Biofisico della Osteocalcina nella prevenzione primaria del diabete mellito, 2008. Available at: http://www.fcenews.it/index.php?option=com_content&task=view&id=909&Itemid=47

Stagnaro S, West PJ, Hu FB, Manson JE, Willett WC. Diet and risk of type 2 diabetes. N Engl J Med 2002; 346(4): 297-98. [Medline

Davis PF, Barbee KA. Hemodynamics and atherogenesis. Endothelial surface dynamics in flow signal transuction. Recent Advances in Atherosclerosis Research. Ann NY Acad Sci 1995; 748: 86-103. http://dx.doi.org/10.1111/j.1749-6632.1994.tb17310.x

Lebedeva NN. Activation of hemopoesis in red bone marrow T.I. 2002.

Bakaliuk TG, Zoria LV, Pogorila MA. Microwave resonance therapy in primary osteoarthrosis: the pathogenetic validation of its clinical use, Patol Fiziol Eksp Ter 1998; 4: 22-5.

Kozhemyakin A. Report on clinical evaluation for EHF – IR therapies device portable with changeable oscillators “Cem Tech”. Spinor O’LTD, 2008. Available at: http://www.schungit-mineralien.de/CEM-TECH/docs/Ergebnisse-klinik-eng.pdf

Caramel S. Meccanismi d’azione sconosciuti dell’acqua termale sulfurea. JOQBS, 2012. Available at: http://www.sisbq.org/uploads/5/6/8/7/5687930/h2s.pdf

Stagnaro S, Caramel S. A new way of therapy based on water memory information: the quantum biophysical approach, JOQBS, 2011. Available at: http://www.sisbq.org/uploads/5/6/8/7/5687930/qbtherapy.pdf

Stagnaro S, Caramel S. The genetic reversibility in Oncology. JOQBS, 2011. Available at: http://www.sisbq.org/uploads/5/6/8/7/5687930/reverse_oncology.pdf

Pellionsz AJ. The principle of recursive genome function. Cerebellum (Springler Verlag), 2008; 7. Available at: http://junkdna.com/pellionisz_principle/pellionisz_principle_from_web.pdf

Pellionisz AJ, Graham R, Pellionisz PA, Perez JC. Recursive genome function of the cerebellum: geometric unification of neuroscience and genomics. Chapter in Handbook: “The Cerebellum and cerebellar disorders” Ed. Dr. Mario Manto, Springer Verlag, 2011.

Stagnaro S, Caramel S. The principle of recursive genome function: QBS clinical and experimental evidences. JOQBS, 2011. Available at: http://www.sisbq.org/uploads/5/6/8/7/5687930/prgf_qbsevidences.pdf




How to Cite

Stagnaro, S., & Caramel, . S. (2012). Quantum Therapy: A New Way in Osteoporosis Primary Prevention and Treatment. Journal of Pharmacy and Nutrition Sciences, 2(1), 34–42. https://doi.org/10.6000/1927-5951.2012.02.01.5