Dietary Iron is Associated with Memory in Midlife: Longitudinal Cohort Study


 National Survey of Health and Development, 1946 Birth Cohort, Cognitive Decline, Midlife Adults, Nutrition.

How to Cite

Anna P. Rickard, Mark D. Chatfield, Jonathan J. Powell, Alison M. Stephen, & Marcus Richards. (2012). Dietary Iron is Associated with Memory in Midlife: Longitudinal Cohort Study . Journal of Pharmacy and Nutrition Sciences, 2(1), 57–62.


This work examined associations between dietary iron and cognitive function in mid-life adults using data from the 1946 British Birth Cohort, a representative population-based sample of men and women born in England, Scotland or Wales. Linear regression was used to determine the association between dietary iron intake or a measure of available iron (calculated by adjusting iron intake for dietary modifiers that are known to inhibit or enhance iron absorption) at ages 36, 43 and 53 years and cognitive measures at ages 43 and 53 years. Cognitive measures included verbal memory, assessed by a three-trial 15-word learning task, and speed and concentration, assessed by a timed letter search task. Examining the data cross-sectionally; dietary iron at ages 43 and 53 years was positively and significantly associated with verbal memory after adjustment for potential confounders. Examining the data longitudinally; earlier dietary iron exposure was significantly associated with later verbal memory. No associations were observed between dietary iron and measures of speed and concentration when examining the data both cross-sectionally and longitudinally. The current study shows that impaired cognition, specifically memory, resulting from inadequate iron intake may extend beyond childhood and also be present in midlife. This finding, coupled with the high prevalence of people reporting iron intakes below the Lower Reference Nutrition Intake in the UK, provide reason for concern.


Beard JL, Connor JR. Iron status and neural functioning. Annu Rev Nutr 2003; 23: 41-58.

Grantham-McGregor S, Ani C. A review of studies on the effect of iron deficiency on cognitive development in children. J Nutr 2001; 131: 649S-66S; discussion 66S-68S.

Walter T. Impact of iron deficiency on cognition in infancy and childhood. Eur J Clin Nutr 1993; 47: 307-16.

Bruner AB, Joffe A, Duggan AK, et al. Randomised study of cognitive effects of iron supplementation in non-anaemic iron-deficient adolescent girls. Lancet 1996; 348: 992-6.

Murphy ST, Parfrey PS. Erythropoietin therapy in chronic uremia: the impact of normalization of hematocrit. Curr Opin Nephrol Hypertens 1999; 8: 573-8.

Cunningham RS. Anemia in the oncology patient: cognitive function and cancer. Cancer Nurs 2003; 26: 38S-42S.

Ortega RM, Requejo AM, Andres P, et al. Dietary intake and cognitive function in a group of elderly people. Am J Clin Nutr 1997; 66: 803-9.

Lam PK, Kritz-Silverstein D, Barrett Connor E, et al. Plasma trace elements and cognitive function in older men and women: the Rancho Bernardo study. J Nutr Health Aging 2008; 12: 22-7.

Wadsworth M, Kuh D, Richards M, et al. Cohort Profile: The 1946 National Birth Cohort (MRC National Survey of Health and Development). Int J Epidemiol 2006; 35: 49-54.

Paul A, Southgate D. McCance and Widdowson's The Composition of Foods. 4th ed. London 1978.

Holland B, Welch AA, Unwin ID, et al. McCance and Widdowson's The Composition of Foods. London 1991.

Rickard AP, Chatfield MD, Conway RE, et al. An algorithm to assess intestinal iron availability for use in dietary surveys. Br J Nutr 2009; 102: 1678-85.

Black AE. Critical evaluation of energy intake using the Goldberg cut-off for energy intake:basal metabolic rate. A practical guide to its calculation, use and limitations. Int J Obes Relat Metab Disord 2000; 24: 1119-30.

Richards M, Shipley B, Fuhrer R, et al. Cognitive ability in childhood and cognitive decline in mid-life: longitudinal birth cohort study. BMJ 2004; 328: 552.

Richards M, Hardy R, Wadsworth ME. Alcohol consumption and midlife cognitive change in the British 1946 birth cohort study. Alcohol Alcohol 2005; 40: 112-7.

Nelson HE, Willison JR. National Adult Reading Test. 2nd ed. Windsor, UK: NFER-Nelson 1991.

Murray-Kolb LE, Beard JL. Iron treatment normalizes cognitive functioning in young women. Am J Clin Nutr 2007; 85: 778-87.

Connor JR, Snyder BS, Arosio P, et al. A quantitative analysis of isoferritins in select regions of aged, parkinsonian, and Alzheimer's diseased brains. J Neurochem 1995; 65: 717-24.

Stoltzfus RJ. Iron deficiency: global prevalence and consequences. Food Nutr Bull 2003; 24: S99-103.

Bates B, Lennox A, Swan G. National Diet and Nutrition Survey Headline results from Year 1 of the Rolling Programme 2008/2009.

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Copyright (c) 2012 Anna P. Rickard, Mark D. Chatfield, Jonathan J. Powell, Alison M. Stephen , Marcus Richards