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In Vitro Cytotoxic Activity of Isostichopus badionotus, a Sea Cucumber from Yucatan Peninsula Coast

Authors

  • Aida R. Pérez-Espadas

    Universidad Autónoma de Nuevo León, Av. Pedro de Alba s/n, Ciudad Universitaria, CP 66450, Nuevo León, México

  • María J. Verde-Star

    Universidad Autónoma de Nuevo León, Av. Pedro de Alba s/n, Ciudad Universitaria, CP 66450, Nuevo León, México

  • Catalina Rivas-Morales

    Universidad Autónoma de Nuevo León, Av. Pedro de Alba s/n, Ciudad Universitaria, CP 66450, Nuevo León, México

  • Azucena Oranday-Cárdenas

    Universidad Autónoma de Nuevo León, Av. Pedro de Alba s/n, Ciudad Universitaria, CP 66450, Nuevo León, México

  • María E. Morales-Rubio

    Universidad Autónoma de Nuevo León, Av. Pedro de Alba s/n, Ciudad Universitaria, CP 66450, Nuevo León, México

  • Lorena V. León-Deniz

    Universidad Autónoma de Yucatán, Carr. Xmatkuil, Km. 15.5, Apartado Postal No. 116, CP 97315, Yucatán, México

  • Jaqueline Canul-Canché

    Universidad Autónoma de Yucatán, C. 41 No. 421 Col. Industrial, CP 97150, Mérida, Yucatán, México

  • Leovigildo Quijano

    Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, 04510, México, D. F., México

DOI:

https://doi.org/10.6000/1927-5951.2014.04.03.3

Keywords:

 Holothurian, organic extracts, selectivity index, HeLa cells.

Abstract

The in vitro cytotoxic activity of hexane, ethyl acetate and butanol extracts of the sea-cucumber Isostichopus badionotus (Holothuroidea) was tested against normal cells (Vero), human cervical carcinoma (HeLa) and breast adenocarcinoma (MCF-7 and MDA-MB-231) ATCC cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. Hexane extracts from body walls and viscera showed high cytotoxic activity against HeLa cells (IC50’s = 48.5 and 42.5 µg mL-1, respectively), while the ethyl acetate extract of body walls was considered low active (IC50 = 98.3 μg mL-1). In addition, the body walls hexane extract showed a good selectivity index value of 12.0.

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Published

2014-06-05

Issue

Vol. 4 No. 3 (2014)

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Articles

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Copyright (c) 2014 Aida R. Pérez-Espadas, María J. Verde-Star, Catalina Rivas-Morales, Azucena Oranday-Cárdenas, María E. Morales-Rubio, Lorena V. León-Deniz, Jaqueline Canul-Canché , Leovigildo Quijano

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

In Vitro Cytotoxic Activity of Isostichopus badionotus, a Sea Cucumber from Yucatan Peninsula Coast . (2014). Journal of Pharmacy and Nutrition Sciences , 4(3), 183-186. https://doi.org/10.6000/1927-5951.2014.04.03.3

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