The present study assessed the in vivo effects of fatty acids on inflammation and carcinogenesis in mice. Fifteen fatty acids were examined for their effects on the inhibitory effect of caffeine on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear oedema in mice. Furthermore, linoleic acid was studied for its effects on the inhibitory effect of caffeine on carcinogenesis in mouse skin initiated with 7,12-dimethylbenz[a]anthracene (DMBA) and promoted by TPA. Among fatty acids, linoleic, γ-linolenic and oleic acids most strongly blocked the inhibitory effect of caffeine on TPA-induced ear oedema. Furthermore, linoleic acid also markedly blocked the inhibitory effect of caffeine on the tumour-promoting activity of TPA. This is the first report to suggest that fatty acids, such as linoleic, γ-linolenic and oleic acids, block the anti-inflammatory activity of caffeine on TPA-induced inflammation in mice. Linoleic acid blocked the inhibitory effect of caffeine on tumour promotion by TPA in the two-stage mouse skin carcinogenesis model. These results suggest that intake of linoleic acid requires attention.
Bull AW, Soullier BK, Wilson PS, Hayden MT, Nigro ND. Promotion of azoxymethane-induced intestinal cancer by high-fat diet in rats. Cancer Res 1979; 39: 4956-9.
Sakaguchi M, Hiramatsu Y, Takada H, et al. Effect of dietary unsaturated and saturated fats on azoxymethane-induced colon carcinogenesis in rats. Cancer Res 1984; 44: 1472-7.
Yasukawa K, Takido M, Takeuchi M, Nakagawa S. Inhibitory effect of glycyrrhizin and caffeine in two-stage carcinogenesis in mice. Yakugaku Zasshi 1988; 108: 794-6.
Yasukawa K. Inhibitory effect of combined treatment of glycyrrhizin and caffeine on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. J Pharm Nutr Sci 2013; 3: 202-5. http://dx.doi.org/10.6000/1927-5951.2013.03.03.4
Yasukawa K. Cancer chemopreventive agents: natural pentacyclic triterpenoids. In ‘Pentacyclic triterpenes as promising agents in cancer’, Ed Salvador JAR. Nova Science Publishers, Inc., New York, 2010, pp 127-57.
Yasukawa K. Medicinal and edible plants as cancer preventive agents. In ‘Drug discovery research in pharmacognosy’, Eds Vallisuta O and Olimat SM. InTech, Croatia, 2012; pp. 181-208. http://dx.doi.org/10.5772/34545
Yasukawa K. Cancer chemopreventive agents: Tetracyclic triterpenoids. In ‘Horizons in cancer research Vol 51’, Ed Watanabe HS. Nova Science Publishers, Inc., New York, 2013, pp 89-113.
Yasukawa K, Takido M, Takeuchi M, nakagawa S. Effect of chemical constituents from plants on 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice. Chem Pharm Bull (Tokyo) 1989; 37: 1071-1073. http://dx.doi.org/10.1248/cpb.37.1071
Lovejoy JC. The influence of dietary fat on insulin resistance. Curr Diab Rep 2002; 2: 435-40. http://dx.doi.org/10.1007/s11892-002-0098-y
Fukuchi S, Hamaguchi K, Seike M, et al. Role of fatty acid composition in the development of metabolic disorders in sucrose-induced obese rats. Exp Biol Med (Maywood) 2004; 229: 486-93.
Pala V, Krogh V, Muti P, et al. Erythrocyte membrane fatty acids and subsequent breast cancer: a prospective Italian study. J Natl Cancer Inst 2001; 93: 1088-95. http://dx.doi.org/10.1093/jnci/93.14.1088
Akihisa T, Tokuda H, Ogata M, et al. Cancer chemopreventive effects of polyunsaturated fatty acids. Cancer Lett 2004; 205: 9-13. http://dx.doi.org/10.1016/S0304-3835(03)00284-2
Harvey KA, Walker CL, Pavlina TM, et al. Long-chain saturated fatty acids induce pro-inflammatory responses and impact endothelial cell growth. Clin Nutr 2010; 29: 492?500. http://dx.doi.org/10.1016/j.clnu.2009.10.008
Harvey KA, Walker CL, Xu Z, et al. Oleic acid inhibits stearic acid-induced inhibition of cell growth and pro-inflammatory responses in human aortic endothelial cells. J Lipid Res 2010; 51: 3470?80. http://dx.doi.org/10.1194/jlr.M010371
Sauer LA, Blask DE, Dauchy RT. Dietary factors and growth and metabolism in experimental tumors. J Nutr Biochem 2007; 18: 637?49. http://dx.doi.org/10.1016/j.jnutbio.2006.12.009
Simopoulos AP. Evolutionary aspects of diet, the omega-6/omega-3 ratio and genetic variation: nutritional implications for chronic diseases. Biomed Pharmacother 2006; 60: 502-7. http://dx.doi.org/10.1016/j.biopha.2006.07.080
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright (c) 2015 Ken Yasukawa