The Effect of Mulberry Leaf Tea on Postprandial Glycemic Control and Insulin Sensitivity: A Randomized, Placebo-Controlled Crossover Study


Mulberry leaf tea
Blood glucose
Insulin Sensitivity
Oral glucose tolerance test

How to Cite

Sukriket, P., Surapong Lookhanumarnjao, & Bumrungpert, . A. (2016). The Effect of Mulberry Leaf Tea on Postprandial Glycemic Control and Insulin Sensitivity: A Randomized, Placebo-Controlled Crossover Study. Journal of Pharmacy and Nutrition Sciences, 6(1), 33–37.


Leaves of mulberry (Morus alba, L.) have been one of the prominent herbs widely used by traditional medicine for the treatment of diabetes mellitus. The objective of this study was to evaluate the effect of mulberry leaf tea on postprandial plasma glucose and insulin sensitivity after the ingestion of sucrose solution in non-diabetic subjects. This study was conducted on 14 subjects, with a crossover design. Subjects were initially screened for non-diabetic status (FBS < 126 mg/dL). Subjects were randomized to either mulberry leaf tea or water as control. The drink was consumed 30 minutes prior to oral administration of 75 grams sucrose solution. Blood samples were collected before (time point 0) and after sucrose ingestion at 30, 60, 90, 120, and 150 minutes. The treatment group which received mulberry leaf tea prior to the tolerance test tends to have a lower level of plasma glucose, serum insulin concentrations and AUC0-150 compared to the controlled group, but without significant difference. The mean difference of the incremental glucose level at each time point also tends to be lower for the mulberry group, with significant difference at 30-min time point (p = 0.04). No significant differences were found in insulin sensitivity. Therefore, the consumption of mulberry leaf tea may aid in postprandial glycemic control during the first 30 minutes after meal.


American Diabetes Association. Economic costs of diabetes in the US in 2002: Diabetes Care 2003; 26: 917-32.

Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for 2000 and projections for 2030. Diabetes Care 2004; 27: 1047-53.

Olokoba AB, Obateru OA, Olokoba LB. Type 2 Diabetes Mellitus: A Review of current trends. Oman Med J 2012; 27: 269-73.

Grover J, Yadav S, Vats V. Medicinal plants of India with anti-diabetic potential. J Ethnopharmacol 2002; 81: 81-100.

Gulubova R, Boiadzhiev T. Morphological changes in the endocrine pancreas of the rabbit after administration of a Morus alba extract. Eksp Med Morfol 1975; 14: 166-71.

Hikino H, Mizuno T, Oshima Y, Konno C. Isolation and hypoglycemic activity of Moran A, a glycoprotein of Morus alba root barks. Planta Med 1985; 51: 159-160.

Hosseinzadeh H, Sadeghi A. Antihyperglycemic effects of Morus nigra and Morus alba in mice. Pharm Pharmacol Lett 1999; 9: 63-5.

Jang M-H, Kim H, Shin M-C, et al. Administration of Folium mori extract decreases nitric oxide syntase expression in the hypothalamus of streptozotocin-induced diabetic rats. J Pharmacol 2002; 90: 189-92.

Nojima H, Kimura I, Chen FJ, et al. Antihyperglycemic effects of N-containing sugars from Xanthocercis zambesiaca, Morus bombycis, Aglaonema treubii, and Castanospermum australe in streptozotocin-diabetic mice. J Nat Prod 1998; 61: 397-400.

Lemus I, Garcia R, Delvillar E, et al. Hypoglycemic activity of four plants used in Chilean popular medicine. Phytother Res 1999; 13: 91-4.<91::AID-PTR350>3.0.CO;2-8

Litthilert P. Effect of mulberry (Morus alba Linn.) leaves extracts on plasma glucose level in streptozotocin-induced diabetic rats. Bangkok: Mahidol University; 2001.

Sharaf A, Mansour MY. Pharmacological studies on the leaves of Morus alba, with special reference to its hypoglycemic activity. Planta Med 1964; 12: 71-6.

Kimura T, Nakagawa K, Kubota H, et al. Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans. J Agric Food Chem 2007; 55: 5869-74.

Kwon HJ, Chung JY, Kim JY, et al. Comparison of 1-deoxynojirimycin and aqueous mulberry leaf extract with emphasis on postprandial hypoglycemic effects: In vivo and in vitro studies. J Agric Food Chem 2011; 59: 3014-9.

Hansawasdi C, Kawabata J. Alpha-Glucosidase inhibitory effect of mulberry (Morus alba) leaves on Caco-2. Fitoterapia 2006; 77: 568-73.

Mudra M, Ercan-Fang N, Zhong L, et al. Influence of mulberry leaf extract on the blood glucose and breath hydrogen response to ingestion of 75 g sucrose by type 2 diabetic and control subjects. Diabetes Care 2007; 30: 1272-4.

Yatsunami K, Ichida M, Onodera S. The relationship between 1-deoxynojirimycin content and a-glucosidase inhibitory activity in leaves of 276 mulberry cultivars (Morus spp.). J Nat Med 2008; 62: 63-6.

Zhong L, Furne JK, Levitt MD. An extract of black, green, and mulberry teas causes malabsorption of carbohydrate but not of triacylglycerol in healthy volunteers. Am J Clin Nutr 2006; 84: 551-5.

Li Y-G, Ji D-F, Zhong S, et al. Hybrid of 1-deoxynojirimycin and polysaccharide from mulberry leaves treat diabetes mellitus by activating PDX-1/insulin-1 signaling pathway and regulating the expression of glucokinase, phosphoenolpyruvate carboxykinase and glucose-6-phosphatase in alloxan-induced diabetic mice. J Ethnopharmacol 2011; 134: 961-70.

Sinsatienporn S, Boonrood U, Chavalittumrong P, et al. Clinical study of Morus alba Linn. on glycemic control and blood lipids in patients with type 2 diabetes: A preliminary study. Siriraj Med J 2006; 58: 1039-41.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Copyright (c) 2016 Parivat Sukriket, Surapong Lookhanumarnjao , Akkarach Bumrungpert