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Inhibitory Effects of the Aerial Parts of Epimedium koreanum on TPA-Induced Inflammation and Promotion in Two-Stage Carcinogenesis in Mouse Skin

Authors

  • Ken Yasukawa

    Nihon University, Chiba 274-8555, Japan

  • Sung-Kwon Ko

    Semyung University, Chungcheongbuk 390-711, Korea

  • Wan-Kyunn Whang

    Chung-Ang University, Seoul 156-756, Korea

DOI:

https://doi.org/10.6000/1927-5951.2016.06.02.1

Keywords:

 Cancer chemoprevention, antitumour-promoting activity, two-stage carcinogenesis, prenyl flavonol glycosides, Epimedium koreanum.

Abstract

Cancer prevention by supplements offers the most cost-effective long-term health strategy. Methanol extracts from the aerial parts of Epimediumkoreanum were previously found to inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammatory ear oedema and tumour promotion by TPA in the two-stage mouse skin carcinogenesis model. Four prenyl flavonol glycosides (14) were isolated from the active fraction of this extract, and were identified. The isolated compounds showed inhibitory activity against TPA-induced ear inflammatory ear oedema. The 50% inhibitory dose (ID50) of icariin (1), epimedin A (2), epimedin B (3) and epimedin C (4) for TPA-induced inflammation ranged from 114 to 255 nmol/ear, suggesting greater potency than indomethacin (ID50: 908 nmol/ear), an anti-inflammatory drug. Thus, the epimedium herb may be useful in cancer prevention.

References

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Published

2016-03-05

Issue

Vol. 6 No. 2 (2016)

Section

Articles

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Copyright (c) 2016 Ken Yasukawa, Sung-Kwon Ko , Wan-Kyunn Whang

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

Inhibitory Effects of the Aerial Parts of Epimedium koreanum on TPA-Induced Inflammation and Promotion in Two-Stage Carcinogenesis in Mouse Skin . (2016). Journal of Pharmacy and Nutrition Sciences , 6(2), 38-42. https://doi.org/10.6000/1927-5951.2016.06.02.1

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