Background: Atopic dermatitis is a disease with a lot of clinical interest because it is the point of attachment between allergic diseases and autoimmune diseases. Probiotics and synbiotics favor the expression of anti-inflammatory Th1 cytokines which produces therapeutic benefits in patients with atopic dermatitis as revealed by recent meta-analysis.
Material and Method: Six patients (3 women and 3 men) suffering from moderate atopic dermatitis aged between 16 and 28 years were treated with Bifidobacterium lactis BS01, Lactobacillus rhamnosus LR05 and prebiotic fructo -oligosaccharides (2x109CFU) once daily in a period of four months added to their previously scheduled topical treatment. SCORAD index and atopic dermatitis quality of life test (QoLIAD) prior to treatment and four months after treatment were analyzed.
Results: After 4 months of treatment we objectified clinical improvement by reducing the SCORAD index (average of 6 points) and better results in QoLIAD test in 5 of the 6 patients. Previously scheduled medical treatment remained unchanged and no side effect was observed in any of the patients treated.
Discussion: Most of our patients treated obtained clinical improvement and in quality of life without adverse effects, this fact support the results of recent papers concluding that the use of probiotics in diary clinical practice is a safe coadyuvant and possibly effective in the treatment of atopic dermatitis.
Lilly DM, Stillwell RH. Probiotics: Growth-promoting Factors Produced by Microorganisms. Science 1965; 147(3659): 747-8. http://dx.doi.org/10.1126/science.147.3659.747
Isolauri E, Rautava S, Salminen S. Probiotics in the development and treatment of allergic disease. Gastroenterology clinics of North America 2012; 41(4): 747-62. http://dx.doi.org/10.1016/j.gtc.2012.08.007
Ozdemir O. Various effects of different probiotic strains in allergic disorders: an update from laboratory and clinical data. Clinical and Experimental Immunology 2010; 160(3): 295-304. http://dx.doi.org/10.1111/j.1365-2249.2010.04109.x
Kim JY, Kwon JH, Ahn SH, Lee SI, Han YS, Choi YO, et al. Effect of probiotic mix (Bifidobacterium bifidum, Bifidobacterium lactis, Lactobacillus acidophilus) in the primary prevention of eczema: a double-blind, randomized, placebo-controlled trial. Pediatr Allergy Immunol 2010; 21(2 Pt 2): e386-93. http://dx.doi.org/10.1111/j.1399-3038.2009.00958.x
Marlow G, Han DY, Wickens K, Stanley T, Crane J, Mitchell EA, Dekker J, Barthow C, Fitzharris P, Ferguson LR, Morgan AR. Differential effects of two probiotics on the risks of eczema and atopy associated with single nucleotide polymorphisms to Toll-like receptors. Pediatr Allergy Immunol 2015: 26: 262-271. http://dx.doi.org/10.1111/pai.12371
Morgan AR, Han DY, Wickens K, Barthow C, Mitchell EA, Stanley TV, Dekker J, Crane J, Ferguson LR. Clinical & Experimental Allergy 2014; (44): 1255-1265. http://dx.doi.org/10.1111/cea.12394
Frei R, Akdis M, O´Mahony L. Prebiotics, probiotics, synbiotics, and the immune system: experimental data and clinical evidence. Curr Opin Gastroenterol 2015; 31: 153-158. http://dx.doi.org/10.1097/MOG.0000000000000151
Kuitunen M. Probiotics and prebiotics in preventing food allergy and eczema. Curr Opin Allergy Clin Immunol 2013; 13: 280e6.
Strachan DP. Prebiotics, probiotics, synbiotics, and the immune system: experimental data and clinical evidence. Thorax 2000; 55(Suppl 1): S2-S10. http://dx.doi.org/10.1136/thorax.55.suppl_1.S2
Frei R, Lauener RP, Crameri R, et al. Microbiota and dietary interactions: an update to the hygiene hypothesis? Allergy 2012; 67: 451-461. http://dx.doi.org/10.1111/j.1398-9995.2011.02783.x
Karimi K, Kandiah N, Chau J, et al. A Lactobacillus rhamnosus strain induces a heme oxygenase dependent increase in Foxp3? regulatory T cells. PLoS One 2012; 7: e47556. http://dx.doi.org/10.1371/journal.pone.0047556
Klaenhammer TR, Kleerebezem M, Kopp MV, Rescigno M. The impact of probiotics and prebiotics on the immune system. Nature Reviews Immunology 2012; 12(10): 728-34. http://dx.doi.org/10.1038/nri3312
Konieczna P, Ferstl R, Ziegler M, et al. Immunomodulation by Bifidobacterium infantis 35624 in the murine lamina propria requires retinoic acid-dependent and independent mechanisms. PLoS One 2013; 8: e62617. http://dx.doi.org/10.1371/journal.pone.0062617
Konieczna P, Groeger D, Ziegler M, et al. Bifidobacterium infantis 35624 administration induces Foxp3 T regulatory cells in human peripheral blood: potential role for myeloid and plasmacytoid dendritic cells. Gut 2012; 61: 354-366. http://dx.doi.org/10.1136/gutjnl-2011-300936
Shanahan F, Quigley EM. Manipulation of the microbiota for treatment of IBS and IBD-challenges and controversies. Gastroenterology 2014; 146: 1554-1563. http://dx.doi.org/10.1053/j.gastro.2014.01.050
Eyerich K, Novak N. Immunology of atopic eczema: overcoming the Th1/Th2 paradigm. Allergy 2013; 68: 974-82. http://dx.doi.org/10.1111/all.12184
Haribhai D, Williams JB, Jia S, et al. A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity. Immunity 2011; 35(1): 109-2. http://dx.doi.org/10.1016/j.immuni.2011.03.029
Ashram R, Shan NP. Immune system stimulation by probiotic microorganisms. Crit Rev Food Sci Nutr 2014; 54: 938-56. http://dx.doi.org/10.1080/10408398.2011.619671
Whalley D, McKenna SP, Dewar AL, Erdman RA, Kohlmann T, Niero M, Cook SA, Crickx B, Herdman MJ, Frech F, Van Assche D. A new instrument for assessing quality of life in atopic dermatitis: international development of the Quality of Life Index for Atopic Dermatitis (QoLIAD). Br J Dermatol 2004; 150(2): 274-83. http://dx.doi.org/10.1111/j.1365-2133.2004.05783.x
da Costa Baptista IP, Accioly E, de Carvalho Padilha P. Effect of the use of probiotics in the treatment of children with atopic dermatitis; a literature review. Nutr Hosp 2013; 28(1): 16-26.
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