Cordyceps militaris (L.) Link: Chemical Bioactive Compounds and Pharmacological Activities


 Cordyceps militaris,cordycepin, bioactive compound, pharmacological activity, traditional medicine.

How to Cite

Do Hai Lan, Nguyen Thi Kim Thu, Pham Thi Lan, Pham Van Nha, & Bui Thanh Tung. (2016). Cordyceps militaris (L.) Link: Chemical Bioactive Compounds and Pharmacological Activities. Journal of Pharmacy and Nutrition Sciences, 6(4), 153–159.


Cordyceps militaris (L.) Link is an important medicinal mushroom used in traditional medicine for treatment of many diseases and improving human health. C. militaris are now widely used in many modern pharmaceutical dosages. It contains many bioactive compounds such as cordycepin, adenosine, sterols, polysaccharides, etc. These compounds provided many beneficial biological activities such as anticancer, antiproliferative, pro-sexual, antioxidant, antibacterial, antifungal, antiviral, immunomodulatory, antiinflammatory and others for C. militaris. The present review highlights the chemical bioactive compounds and pharmacological activities of this medicinal mushroom C. militaris.


Mizuno T. Medicinal effects and utilization of Cordyceps (Fr.) Link (Ascomycetes) and Isaria Fr.(Mitosporic Fungi) Chinese caterpillar fungi. International Journal of Medicinal Mushrooms 1999; 1(3).

Frederiksen S, Malling H, Klenow H. Isolation of 3?-deoxyadenosine (cordycepin) from the liquid medium of Cordyceps militaris (L. ex Fr.) Link. Biochimica et Biophysica Acta (BBA)-Nucleic Acids and Protein Synthesis 1965; 95(2): 189-93.

Xiao J-H, Xiong Q. Nucleosides, a valuable chemical marker for quality control in traditional Chinese medicine Cordyceps. Recent Patents on Biotechnology 2013; 7(2): 153-66.

Tuli HS, Sandhu SS, Sharma A. Pharmacological and therapeutic potential of Cordyceps with special reference to Cordycepin. 3 Biotech 2014; 4(1): 1-12.

Yue K, Ye M, Zhou Z, Sun W, Lin X. The genus Cordyceps: a chemical and pharmacological review. Journal of Pharmacy and Pharmacology 2013; 65(4): 474-93.

Jiang Y, Wong J, Fu M, Ng T, Liu Z, Wang C, et al. Isolation of adenosine, iso-sinensetin and dimethylguanosine with antioxidant and HIV-1 protease inhibiting activities from fruiting bodies of Cordyceps militaris. Phytomedicine 2011; 18(2): 189-93.

Smiderle FR, Sassaki GL, Van Griensven LJ, Iacomini M. Isolation and chemical characterization of a glucogalactomannan of the medicinal mushroom Cordyceps militaris. Carbohydrate Polymers 2013; 97(1): 74-80.

Wang Y, Li D, Wang Y, Zheng T. Integrated extracting technology of cordycepin and polysaccharides in Cordyceps militaris. Acta Botanica Boreali-occidentalia Sinica 2004; 25(9): 1863-7.

Yu R, Wang L, Zhang H, Zhou C, Zhao Y. Isolation, purification and identification of polysaccharides from cultured Cordyceps militaris. Fitoterapia 2004; 75(7): 662-6.

Seth R, Haider SZ, Mohan M. Pharmacology, phytochemistry and traditional uses of Cordyceps sinensis (Berk.) Sacc: A recent update for future prospects. Indian J Tradit Knowl 2014; 13: 551-6.

Li S, Li P, Lai C, Gong Y, Kan KK, Dong TT, et al. Simultaneous determination of ergosterol, nucleosides and their bases from natural and cultured Cordyceps by pressurised liquid extraction and high-performance liquid chromatography. Journal of Chromatography A 2004; 1036(2): 239-43.

Zhou X, Gong Z, Su Y, Lin J, Tang K. Cordyceps fungi: natural products, pharmacological functions and developmental products. Journal of Pharmacy and Pharmacology 2009; 61(3): 279-91.

Yang FQ, Feng K, Zhao J, Li SP. Analysis of sterols and fatty acids in natural and cultured Cordyceps by one-step derivatization followed with gas chromatography–mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 2009 7/12/; 49(5): 1172-8.

Kwan-Won Y, Suh HJ, Bae S-H, Lee C-S, Kim SH, Yoon C-S. Chemical properties and physiological activities of stromata of Cordyceps militaris. Journal of Microbiology and Biotechnology 2001; 11(2): 266-74.

Bizarro A, Ferreira IC, Sokovi? M, Van Griensven LJ, Sousa D, Vasconcelos MH, et al. Cordyceps militaris (L.) Link fruiting body reduces the growth of a non-small cell lung cancer cell line by increasing cellular levels of p53 and p21. Molecules 2015; 20(8): 13927-40.

Lin Y-W, Chiang B-H. Anti-tumor activity of the fermentation broth of Cordyceps militaris cultured in the medium of Radix astragali. Process Biochemistry 2008; 43(3): 244-50.

Jie L, Shijie Y, Xu Y, Zheng C, Jingluo L. Anticarcinogenic Effect and Hormonal Effect of Cordyceps militaris Link.[J

Cheolpark SHH, Jae-Yunlee G-YK, Byung TC, Yongtealee DIP, Park Y-M, Jeong Y-K, et al. Growth inhibition of U937 leukemia cells by aqueous extract of Cordyceps militaris through induction of apoptosis. Oncology reports 2005; 13: 1211-6.

Reis FS, Barros L, Calhelha RC, ?iri? A, Van Griensven LJ, Sokovi? M, et al. The methanolic extract of Cordyceps militaris (L.) Link fruiting body shows antioxidant, antibacterial, antifungal and antihuman tumor cell lines properties. Food and Chemical Toxicology 2013; 62: 91-8.

Jing Y, Cui X, Chen Z, Huang L, Song L, Liu T, et al. Elucidation and biological activities of a new polysaccharide from cultured Cordyceps militaris. Carbohydrate Polymers 2014; 102: 288-96.

Yu R, Yang W, Song L, Yan C, Zhang Z, Zhao Y. Structural characterization and antioxidant activity of a polysaccharide from the fruiting bodies of cultured Cordyceps militaris. Carbohydrate Polymers 2007; 70(4): 430-6.

Shin S, Kwon J, Lee S, Kong H, Lee S, Lee C-K, et al. Immunostimulatory Effects of Cordyceps militaris on Macrophages through the Enhanced Production of Cytokines via the Activation of NF-?B. Immune Network 2010; 10(2): 55-63.

Ohta Y, Lee J-B, Hayashi K, Fujita A, Park DK, Hayashi T. In vivo anti-influenza virus activity of an immunomodulatory acidic polysaccharide isolated from Cordyceps militaris grown on germinated soybeans. Journal of Agricultural and Food Chemistry 2007; 55(25): 10194-9.

Lee JS, Hong EK. Immunostimulating activity of the polysaccharides isolated from Cordyceps militaris. International Immunopharmacology 2011; 11(9): 1226-33.

Han ES, Oh JY, Park H-J. Cordyceps militaris extract suppresses dextran sodium sulfate-induced acute colitis in mice and production of inflammatory mediators from macrophages and mast cells. Journal of Ethnopharmacology 2011; 134(3): 703-10.

Hsu C-H, Sun H-L, Sheu J-N, Ku M-S, Hu C-M, Chan Y, et al. Effects of the immunomodulatory agent Cordyceps militaris on airway inflammation in a mouse asthma model. Pediatrics & Neonatology 2008; 49(5): 171-8.

Won S-Y, Park E-H. Anti-inflammatory and related pharmacological activities of cultured mycelia and fruiting bodies of Cordyceps militaris. Journal of Ethnopharmacology 2005 1/15/; 96(3): 555-61.

Park BT, Na KH, Jung EC, Park JW, Kim HH. Antifungal and anticancer activities of a protein from the mushroom Cordyceps militaris. The Korean Journal of Physiology & Pharmacology 2009; 13(1): 49-54.

Wong JH, Ng TB, Wang H, Sze SCW, Zhang KY, Li Q, et al. Cordymin, an antifungal peptide from the medicinal fungus Cordyceps militaris. Phytomedicine 2011; 18(5): 387-92.

Trigg P, Gutteridge W, Williamson J. The effects of cordycepin on malaria parasites. Transactions of the Royal Society of Tropical Medicine and Hygiene 1971; 65(4): 514-20.

Lee HH, Park H, Sung G-H, Lee K, Lee T, Lee I, et al. Anti-influenza effect of Cordyceps militaris through immunomodulation in a DBA/2 mouse model. Journal of Microbiology 2014; 52(8): 696-701.

Lin W-H, Tsai M-T, Chen Y-S, Hou RC-W, Hung H-F, Li C-H, et al. Improvement of sperm production in subfertile boars by Cordyceps militaris supplement. The American Journal of Chinese Medicine 2007; 35(04): 631-41.

Jung K, Kim I-H, Han D. Effect of medicinal plant extracts on forced swimming capacity in mice. Journal of Ethnopharmacology 2004; 93(1): 75-81.

Choi SB, Park CH, Choi MK, Jun DW, Park S. Improvement of Insulin Resistance and Insulin Secretion by Water Extracts of Cordyceps militaris, Phellinus linteus, and Paecilomyces tenuipes in 90% Pancreatectomized Rats. Bioscience, Biotechnology, and Biochemistry 2004 2004/01/01; 68(11): 2257-64.

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Copyright (c) 2016 Do Hai Lan, Nguyen Thi Kim Thu, Pham Thi Lan, Pham Van Nha , Bui Thanh Tung