Influence of Different Polypeptides Fractions Derived from Sus Scrofa Immune Organs on the Rats Immunological Reactivity


DDW, immunodeficiency, interleukin, CD3, CD4, thymus, lymph nodes, spleen, tissue-specific bioactive compounds

How to Cite

L.V. Fedulova, Е.R. Vasilevskaya, Е.А. Kotenkova, A.A. Elkina, M.G. Baryshev, & A.B. Lisitsyn. (2017). Influence of Different Polypeptides Fractions Derived from Sus Scrofa Immune Organs on the Rats Immunological Reactivity. Journal of Pharmacy and Nutrition Sciences, 7(2), 35–40.


The influence of protein-peptide compounds, extracted with deuterium water as solubilizer agent from mixture of Sus scofa thymus, spleen and lymph nodes extracts, was carried out on Wistar rats with cytostatic-induced immunodeficiency model. Intragastric administration of extract fraction with molecular weight more than 30 kDa, did not lead to significant changes. Thus, polypeptide compounds with molecular weight less than 30 kD, extracted from Sus scofa immune organs, significantly increased T-lymphocytes amount, affected macrophages system by T-helper (CD4) stimulation and activated cycle of complementary cascade. Differences between the experimental results in T-helper synthesis activation (CD4) in animals treated with the medium and low molecular weight fractions can be explained by the ability of biomolecules having a molecular weight less than 30 kDa (in particular, isolated from the spleen, which, in its cellular structure contains key regulatory factors) to change the speed of cell differentiation.


Morozov VG, Havinson VH, Malinin VV. Peptide thymomimetics. SPb: Nauka 2001; 158.

Novikov DK, Sergeev YV, Novikova VI. Characteristic of immunopharmaceutical preparations. Immunopathology, Allergology, Infectology 2002; 4: 7-27.

Manko VM, Petrov RV, Haitov RM. Immunomodulation. Immunologiya 2001; 3: 132-8.

Kovalchuk LN, Martirosova NI, Sokolova EV. The main directions of immunotherapy. Refrakcionnaya hirurgiya i oftal'mologiya 2008; 8(2): 45-50.

Haitov RM, Pinegin BV. Immunomodulators. Farmateka 2004; 85(7) 21-7.

Mebius RE, Kraal G. Structure and function of the spleen. Nat Rev Immunol 2005; 5(8): 606-16.

Chuchkova NN, Styazhkina SN, Sannikova AA, et al. Immunomodulators of natural originEkaterinburg: UrO RAN, 2007; 228.

Karaulov AV. Immunomodulating therapy and respiratory. Pulmonology 2015; 25(1): 106-112.

Zajcev VB, Fedorovskaya NS, Dyakonov DA, et al. Morphofunctional characteristics of human spleen. Vyatskij Medicinskij Vestnik 2011; 4: 3-6.

Maslyakov VV. Purulent-septic complications. International Journal of Applied and Fundamental Research 2012; 8: 20-4.

Zaiko MV, Kozin SV, Pavlova LA. History and perspectives of medical use of raw materials of animal origin. Tradicionnaya Medicina 2014; 1: 42-8.

Cypin AB. The drug Splenopid is new perspective immunomodulator. Medicinskaya Kartoteka 2004; 11: 22-3.

Plenina LV, Soroka NF, Chudakov OP, et al. New domestic immunomodulator. Recept 2008; 1(57): 104-6.

Safiulin ZT, Tkachenko AG. Perspectives of using spleen preparations. Astma i Allergiya 2013; 1: 38-42.

Nascimento AP, Moraes LA, Ferreira NU, et al. The lyophilization process maintains. Evid-Based Compl Alter Med 2015.

Yeh HM. Recovery of deuterium from. Progr Nucl Energy 2010; 52: 516-22.

Basov AA, Bykov IM, Dzhimak SS, et al. Influence of linseed oil and deuterium depleted water. Vopr Pitan 2016; 85(6): 30-8.

Dzhimak SS, Basov AA, Fedulova LV, et al. Correction of metabolic processes in rats. Biol Bull 2015; 42(5): 440-8.

Dzhimak SS, Basov AA, Baryshev MG. Content of deuterium. Doklady Biochem and Biophys 2015; 465: 370-3.

Basov AA, Bykov IM, Fedulova LV, et al. Correction of oxidative metabolism. Medical news of North Caucasus 2016; 11(1): 103-7.

Fedulova LV, Dzhimak SS, Kotenkova EA, et al. Influence of deuterium depleted water. J of Pharm and Nutr Sci 2016; 6(2): 55-60.

Dzhimak SS, Basov ??, Fedulova LV, et al. Determination of deuterium concentration. Aviakosmicheskaya i Ekologicheskaya Meditsina 2016; 50(3): 42-7.

Dzhimak SS, Barishev MG, Basov AA, et al. Influence of deuterium depleted water. Biophysics 2014; 59(4): 614-9.

Dzhimak SS, Basov AA, Kopytov GF, et al. Application of NMR spectroscopy. Russ Phys J 2015; 58(7): 923-9.

Bykov MI, Dzhimak SS, Basov AA, et al. Comparative characteristics of the isotopic D/H. Vopr Pitan 2015; 84(4): 89-96.

Li J, Cheng Y, Zhang X, et al. The in vivo immunomodulatory. Cancer Lett 2013; 337(2): 237-47.

Yingjian L, Junming H, Min C, et al. A health food high-peptide meal. Food Funct 2013; 4(9): 1352-9.

Baas MC, Kuhn C, Valette F, et al. Combining autologous dendritic cell therapy. J Immunol 2014; 193(9): 4696-703.

Calderon D, Prot M, You S, et al. Control of immune response. Am J Transplant 2016; 16(2): 454-67.

Zahorchak AF, Ezzelarab MB, Lu L, et al. In vivo mobilization and functional characterization. Am J Transplant 2016; 16(2): 661-71.

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Copyright (c) 2017 L.V. Fedulova, Е.R. Vasilevskaya, Е.А. Kotenkova, A.A. Elkina, M.G. Baryshev , A.B. Lisitsyn