Abstract
This article presents data on ability of drinking water with depleted concentrations of deuterium (deuterim depleted water – DDW, ?2H = -762 ‰) to influence on the adaptive capacities and functional activity of rats organism during long period of DDW consumption. The obtained data confirms the favorable effect of reduced ?2H on hepatocytes of medium and shows significant (by 10%) increase of body weight among rats which consumed DDW for 3 weeks after birth. It is also shown that when rats consumed DDW, the non-uniform distribution of deuterium in the blood plasma and liver, kidney and heart tissues is observed. At the same time under natural conditions ?2H was significantly lower in blood plasma than in tissues of internal organs (?2H plasma > ?2H of tissues of internal organs), whereas DDW consumption resulted in more significant decrease of ?2H level in blood plasma than in the internal organs, which phenomena was accompanied by change of direction of 2H/1H isotope gradient: ?2H of plasma < ?2H of tissue of internal organs. Stable change in direction of 2H/1H isotope gradient over 3 weeks is expressed by lower rate of weight gain in the first generation of rats. All these facts can be caused by influence of 2H/1H isotope gradient on long-term adaptation mechanisms, but not on short-term adaptation reactions. Decrease of ?2H in blood plasma and tissues of internal organs increases to a greater extent the resistance of an organism to influence of unfavorable environmental factors among future generations of rats consuming DDW for a long time.
References
Symes C, Skhosana F, Butler M, Gardner B, Woodborne S. Isotope (?13C, ?15N, ?2H) diet–tissue discrimination in African grey parrot Psittacus erithacus: implications for forensic studies. Isotopes in Environmental and Health Studies 2017; 53(6): 580-596. https://doi.org/10.1080/10256016.2017.1319832
Wolf N, Bowen GJ, del Rio CM. The influence of drinking water on the dD and d18O values of house sparrow plasma, blood and feathers. The Journal of Experimental Biology 2011; 214: 98-103. https://doi.org/10.1242/jeb.050211
Hurley JM, West JB, Ehleringer JR. Stable isotope models to predict geographic origin and cultivation conditions of marijuana. Science and Justice 2010; 50: 86-93. https://doi.org/10.1016/j.scijus.2009.11.003
Ekaykin AA, Lipenkov VY, Kozachek AV, Vladimirova DO. Stable water isotopic composition of the Antarctic subglacial Lake Vostok: implications for understanding the lake's hydrology. Isotopes in Environmental and Health Studies 2016; 52(4-5): 468-476. https://doi.org/10.1080/10256016.2015.1129327
O’Brien DM. Stable isotope ratios as biomarkers of diet for health research. Annual Review of Nutrition 2015; 35: 565-594. https://doi.org/10.1146/annurev-nutr-071714-034511
Bila WC, Mariano RMS, Silva VR, et al. Applications of deuterium oxide in human health. Isotopes in Environmental and Health Studies 2017; 53(4): 327-343. https://doi.org/10.1080/10256016.2017.1281806
Shikhliarova AI, Zhukova GV, Kit OI, et al. Influence of drinking diet with low content of deuterium on the indicators of the estrous cycle and the adaptive capabilities of the organism in female rats in the presenile age. Medical news of the North Caucasus 2018; 13(1): 85-90. https://doi.org/10.14300/mnnc.2018.13024
Reynard LM, Burt N, Koon HEC, Tuross N. Limits and possibilities in the geolocation of humans using multiple isotope ratios (H, O, N, C) of hair from east coast cities of the USA. Isotopes in Environmental and Health Studies 2016; 52(4-5): 498-512. https://doi.org/10.1080/10256016.2016.1143821
Kravtsov AA, Kozin SV, Vasilevskaya ER, et al. Effect of Drinking Ration with Reduced Deuterium Content on Brain Tissue Prooxidant-Antioxidant Balance in Rats with Acute Hypoxia Model. Journal of Pharmacy and Nutrition Sciences 2018; 8(2): 42-51. https://doi.org/10.6000/1927-5951.2018.08.02.3
Dzhimak SS, Basov AA, Volchenko NN, Samkov AA, Fedulova LV, Baryshev MG. Changes in the functional activity of mitochondria isolated from the liver of rat that passed the preadaptation to ultra-low deuterium concentration. Doklady Biochemistry and Biophysics 2017; 476: 323-325. https://doi.org/10.1134/S1607672917050088
Fatemi F, Dadkhah A, Akbarzadeh K, Dini S, Hatami S, Rasooli A. Hepatoprotective effects of deuterium depleted water (DDW) adjuvant with Saturejarechingeri essential oils. Electronic Journal of Biology 2015; 11(2): 23-32.
Chernukha IM, Fedulova LV, Kotenkova EA, Vasilevskaya ER, Lisitsyn AB. The effect of water with modified isotope (D/H) composition on the reproductive function and postnatal development in rats. Voprosy Pitaniia 2016; 85(5): 36-43.
Syroeshkin A, Pleteneva T, Uspenskaya E, et al. D/H control of chemical kinetics in water solutions under low deuterium concentrations. Chemical Engineering Journal 2018. https://doi.org/10.1016/j.cej.2018.08.213
Boros LG, D’Agostino DP, Katz HE, Roth JP, Meuillet EJ, Somlyai G. Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid substrate cycle. Medical Hypotheses 2016; 87: 69-74. https://doi.org/10.1016/j.mehy.2015.11.016
Luo A-L, Zheng Y-L, Cong F-S. Research progress of biological effects of deuterium-depleted water. Journal of Shanghai Jiaotong University (Medical Science) 2018; 38(4): 467-471.
Cong F-S, Cong F-S, Zhang Y-R, Sheng H-C, Ao Z-H, Zhang S-Y, Wang J-Y. Deuterium-depleted water inhibits human lung carcinoma cell growth by apoptosis. Experimental and Therapeutic Medicine 2010; 1(2): 277-283. https://doi.org/10.3892/etm_00000043
Wang H, Zhu B, He Z, et al. Deuterium-depleted water (DDW) inhibits the proliferation and migration of nasopharyngeal carcinoma cells in vitro. Biomed Pharmacother 2013; 67(6): 489-96. https://doi.org/10.1016/j.biopha.2013.02.001
Pershin SM, Ismailov ESh, Dibirova MM, et al. Multiple increase in productivity of the yeast at reducing the fraction of D2O in water. Doklady Biochemistry and Biophysics 2017; 476: 299-302. https://doi.org/10.1134/S1607672917050039
Strekalova T, Evans M, Chernopiatko A, et al. Deuterium content of water increases depression susceptibility: the potential role of a serotonin-related mechanism. Behavioural Brain Research 2015; 277: 237-244. https://doi.org/10.1016/j.bbr.2014.07.039
Mladin C, Ciobica A, Lefter R, Popescu A, Bild W. Deuterium-depleted water has stimulating effects on long-term memory in rats. Neurosci Lett 2014; 583: 154-8. https://doi.org/10.1016/j.neulet.2014.09.037
Baryshev MG, Dzhimak SS, Bolotin SN, Frolov VYu, Dolgov MA. Methods for obtaining water with low content of deuterium. International Journal of Engineering Research and Applications 2013; 3(1): 523-526.
Dzhimak SS, Shashkov DI, Sharafan MV, Baryshev MG. Determination of the concentrations of 2H natural levels in liquid media using NMR spectroscopy. Memoirs of the Faculty of Physics 2017; 6: e1760901.
Bowen GJ, Chesson L, Nielson K, Cerliug TE, Ehlerrienger JR. Treatment methods for the determination of ?2H and ?18O of hair keratin by continuous?flow isotope?ratio mass spectrometry. Rapid communication in Mass Spectrometry 2005; 19: 2371-2378. https://doi.org/10.1002/rcm.2069
Kreuzer-Martin HW, Ehleringer JR, Hegg EL. Oxygen isotopes indicate most intracellular water in log-phase Escherichia coli is derived from metabolism. PNAS 2005; 102(48): 17337-17341. https://doi.org/10.1073/pnas.0506531102
Zubarev RA. Role of stable isotopes in life – testing isotopic resonance hypothesis. Genomics Proteomics Bioinformatics 2011; 9(1-2): 15-20. https://doi.org/10.1016/S1672-0229(11)60003-X
Chira S, Raduly L, Braicu C, et al. Premature senescence activation in DLD-1 colorectal cancer cells through adjuvant therapy to induce a mirna profile modulating cellular death. Experimental and Therapeutic Medicine 2018; 16(2): 1241-1249. https://doi.org/10.3892/etm.2018.6324
Klotz IM, Frank BH. Catalysis by imidazole of deuterium-hydrogen exchange in amide N-H groups. Science.1962; 138(3542): 830-831. https://doi.org/10.1126/science.138.3542.830
Letuta UG, Avdeeva EI. Magnetic-dependent ATP pool in Escherichia coli. Doklady Biochemistry and Biophysics 2017; 474(1): 196-199. https://doi.org/10.1134/S1607672917030085
Kravchenko DV, Beskhmelnitsyna EA, Korokin MV, Avtina TV, Tishin AN, Kostina DA. Molecular screening of prospective candidates for TRPA1 ion channel selective antagonists. Research Result: Pharmacology and Clinical Pharmacology 2016; 2(1): 63-66. https://doi.org/10.18413/2313-8971-2016-2-1-63-66
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright (c) 2019 S.S. Dzhimak , L.V. Fedulova , A.V. Moiseev , А.А.Basov