Carotenoid Pigments of Red, Green and Brown Macroalgae Species as Potential Active Pharmaceutical Ingredients
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Keywords

Active pharmaceutical ingredients, carotenoid, macroalgae.

How to Cite

Rashidi Othman, Nur Alifah Md Amin, Ainaa Eliah Abu Bakar, Nurrulhidayah Ahmad Fadzillah, & Noraini Mahmad. (2019). Carotenoid Pigments of Red, Green and Brown Macroalgae Species as Potential Active Pharmaceutical Ingredients . Journal of Pharmacy and Nutrition Sciences, 9(1), 14–19. https://doi.org/10.29169/1927-5951.2019.09.01.3

Abstract

Active Pharmaceutical Ingredient (API) is a substance used in a finished pharmaceutical product, intended to furnish pharmacological activity or contribute direct effect in the diagnosis, cure, mitigation, treatment or prevention of disease. It also provides a direct effect in restoring, correcting or modifying physiological functions in human beings. Macroalgae, also known as seaweed, are plant-like organisms that can be found in a marine habitat. Macroalgae has been given huge concern because of its high nutritional value and short-term growth, which is only 45 days per cycle. Therefore, three red macroalgae species of Eucheuma denticulatum, Gracilaria tikvahiae and Kappaphycus striatum), as well as green and brown macroalgae species of Caulerpa lentillifera and Padina pavonica were selected to determine their carotenoids content and composition by using UV-Vis spectrophotometer and HPLC analysis. The main carotenoids identified in red, green and brown macroalgae species were zeaxanthin, lutein, ?-carotene and violaxanthin. Marked differences were observed between red, green and brown macroalgae carotenoids content and composition. Zeaxanthin and ?-carotene were detected in all red, green and brown macroalgae ranged from 3.61 to 21.30 ?g/g DW and 2.44 to 10.70 ?g/g DW respectively. Violaxanthin was found only in green macroalgae (8.93 ?g/g DW) whereas lutein was found only in red macroalgae (9.57 to 38.60 ?g/g DW). In terms of total carotenoid content, green macroalgae contained the highest amount of carotenoid (100.89 ± 14.71 ?g/g DW). The significant outcome of the research will be new natural carotenoid pigment sources as potential active pharmaceutical ingredients which can be beneficial to halal health-promoting products industry.

https://doi.org/10.29169/1927-5951.2019.09.01.3
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References

Dawczynski C, Schubert R, Jahreis, G. Amino acids, fatty acids, a dietary fibre in edible seaweed products. Food Chem 2007; 103: 891-899. https://doi.org/10.1016/j.foodchem.2006.09.041

Thirunavukkarasu P, Pandiyan D, Balaraman K, Subaramaniyan GEG, & Gnana Jothi, Sakthivel Manikkam BS. Thirunavukkarasu R, Pandiyan P, Balaraman D, Subaramaniyan K, Jothi GEG, Manikkam S, Sadaiyappan, B. Isolation of bioactive compound from marine seaweeds against fish pathogenic bacteria Vibrio alginolyticus (VA09) and characterisation by FTIR. J Coast Life Med 2013; 1(1): 26-33.

Shanab SMM, Shalaby EA, El-Fayoumy, EA. Enteromorpha compressa exhibits potent antioxidant activity. J Biomed Biotechnol 2011; 2011: 1-11. https://doi.org/10.1155/2011/726405

Neelamathi E, Kannan, R. Screening and Characterization of Bioactive Compounds of Turbinaria ornata from the Gulf of Mannar, India. Int Adv Res J Sci Eng Tech 2015; 16(2): 243-251.

Rauha JP, Remes S, Heinonen M, Hopia A, Kähkönen M, Kujala T, Pihlaja K, Vuorela H, Vuorela, P. (2000). Antimicrobial effects of Finnish plant extracts containing flavonoids and other phenolic compounds. Int J Food Microbiol 2000; 56(1): 3-12. https://doi.org/10.1016/S0168-1605(00)00218-X

Muhamad SAS, Jamilah B, Russly AR, Faridah, A. In vitro antibacterial activities and composition of Carica papaya cv. Sekaki/ Hong Kong peel extracts. Int Food Res J 2017; 24(3): 976-984.

Mohy El-Din SM, El-Ahwany, AMD. Bioactivity and phytochemical constituents of marine red seaweeds (Jania rubens, Corallina mediterranea and Pterocladia capillacea). J Taibah Univ Sci 2016; 10(4): 471-484. https://doi.org/10.1016/j.jtusci.2015.06.004

Azwanida NN, Hui MS, Afandi A, Mohamed S, Zulhisyam AK, Ayob A, Rusli N, Mat Rasat MS, Mohamed, M. Color Stability Evaluation of Pigment Extracted from Hylocereus polyrhizus, Clitorea ternatae and Pandanus amaryllfolius as Cosmetic Colorants and Premarket Survey on Customer Acceptance on Natural Cosmetic Product. J Trop Resour Sustain Sci 2015; 3(5): 61-67.

Neish AS. Microbial interference with host inflammatory responses. In: Microbial pathogenesis and the intestinal epithelial cell. ASM Press 2003; p.175-190. https://doi.org/10.1128/9781555817848.ch11

Koller M, Muhr A, Braunegg Hurtado AQ. Seaweed production: Farming Kappaphycus in the Philippines. Global Aquaculture Advocate 2002; 5(2): 68-69.

Wenno PA, Syamsuddin R, Jamal, E. Growth and Carrageenan from Kappaphycus alvarezii (Doty) at Different Depths and Their Possible Application in Other Locations. Aquac Indones 2016; 17(1): 20-25. https://doi.org/10.21534/ai.v17i2.58

Ruiz-Sola MA, Rodríguez-Concepción, M. Carotenoid biosynthesis in Arabidopsis: a colorful Pathway. Arabidopsis Book. American Society of Plant Biologists, US 2012.

Moran NA, Jarvik, T. Lateral transfer of genes from fungi underlies carotenoid production in aphids. Science 2010; 328(5978): 624-627. https://doi.org/10.1126/science.1187113

Maeda H, Tsukui T, Sashima T, Hosokawa M, Miyashita, K. Seaweed carotenoid, fucoxanthin, as a multi-functional nutrient. Asia Pac J Clin Nutr 2008; 17(1):196-199.

Cox S, Abu Gannam N, Gupta, S. An assessment of the antioxidant and antimicrobial activity of six species of edible Irish seaweeds. Int Food Res J 2010; 17(1): 205-220.

de Alencar DB, de Carvalho FCT, Reboucas RH, dos Santos DR, dos Santos Pires-Cavalcante KM, de Lima RL, Baracho BM, Bezerra RM, Viana FA, dos Fernandes Vieira RHS, Sampaio AH, de Sousa OV, Sampaio, SS. Bioactive extracts of red seaweeds Pterocladiella capillacea and Osmundaria obtusiloba (Floridophyceae: Rhodophyta) with antioxidant and bacterial agglutination potential. Asian Pac J Trop Med 2016; 9(4): 372-379. https://doi.org/10.1016/j.apjtm.2016.03.015

Othman R, Noh NH, Mohd Hatta FA, Jamaludin, MA. Natural carotenoid pigments of 6 chlorophyta freshwater green algae species. J Pharm Nutri Sci 2018; 8(1): 1-5. https://doi.org/10.6000/1927-5951.2018.08.01.1

Wellburn AR. The Spectral Determination of Chlorophylls a and b, as well as Total Carotenoids, Using Various Solvents with Spectrophotometers of Different Resolution. J Plant Physiol 1994; 144(3): 307-313. https://doi.org/10.1016/S0176-1617(11)81192-2

Burtin P. Nutritional Value of Seaweeds. Electron J Environ Agric Food Chem 2003; 2(4): 498-503.

Diyana F, Hisham S, Chan K, Abdullah, A. Antioxidant activity of red algae Kappaphycus alvarezii and Kappaphycus striatum. Int Food Res J 2015; 22(5): 1977-1984.

McDermid KJ, Stuercke, B. Nutritional composition of edible Hawaiian seaweeds, J Appl Phycol 2003; 15(6): 513-524. https://doi.org/10.1023/B:JAPH.0000004345.31686.7f

Chakraborty S, Santra, SC. Biochemical composition of eight benthic algae collected from Sunderban. Indian J Mar Sci 2008; 37(3): 329-332.

Perez MJ, Falque E, Domínguez, H. Antimicrobial Action of Compounds from Marine Seaweed. Mar Drugs 2016; 14(3): 52. https://doi.org/10.3390/md14030052

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Copyright (c) 2019 Rashidi Othman, Nur Alifah Md Amin, Ainaa Eliah Abu Bakar, Nurrulhidayah Ahmad Fadzillah , Noraini