Chemotherapy Regimen and Incidence of Malnutrition after Chemotherapy in Non-small Cell Lung Cancer


 NSCLC, nutritional status, chemotherapy.

How to Cite

Buntitabhon Sirichancheun, Jantanee Thanomsakcharoen, Piyanuch Intakut, YaowapanKaewpan , & Chuleegone Sornsuvit. (2019). Chemotherapy Regimen and Incidence of Malnutrition after Chemotherapy in Non-small Cell Lung Cancer. Journal of Pharmacy and Nutrition Sciences, 9(2), 60–65.


Lung cancer is the leading cause of death worldwide and in Thailand. The treatment of non-small cell lung (NSCLC) with chemotherapy might affected on nutritional status which could correlate with the treatment response and quality of life. Thus, the objectives of this research were to study the nutritional status of patients after chemotherapy and the incidence of malnutrition. This retrospective longitudinal descriptive study was gathering the information from medical records January, 2013 to December, 2014. A 114 patients were met the inclusion criteria which were completed 4 or 6 cycles of treatment. Body mass index (BMI) and percentage of weight loss were used to assess the nutritional status. Malnutrition was classified when BMI under 18.5 kg/m2 and weight change more than 5%. The average age, baseline weight and BMI were 60.4±10.1 year, 55.0±9.0 kg and 22.0±2.5 kg/m2, respectively. The incidence of malnutrition was 6.1%. Mean BMI decreased from 22.0 kg/m2 to 21.5 kg/m2 after chemotherapy. Patients treated with carboplatin plus paclitaxel showed the highest change of BMI (-0.6 kg/m2) and docetaxel regimen showed the highest incidence of malnutrition (18.8%). According to the base agents; taxane-based regimen showed the most effect on nutritional status and 85% of those patients were malnutrition. In conclusion, docetaxel and carboplatin plus paclitaxel highly affected on nutritional status. In patients treated with those regimens, they should be closely monitored and gave an adequate nutritional advice for the better treatment response, decrease the side effect from chemotherapy and improve patients’ quality of life.


National cancer institute. Hospital-Based Cancer Registry Annual Report 2013. [cited 2018 September 24

Kiss NK, Krishnasamy M, Isenring EA. The Effect of Nutrition Intervention in Lung Cancer Patients Undergoing Chemotherapy and/or Radiotherapy: A Systematic Review. Nutr Cancer 2014; 66(1): 47-56.

Kumar NB. Nutritional Management of Cancer Treatment Effects. Heidelberg: Springer Berlin 2012.

Marín CMM, Laviano A, Pichard C. Nutritional intervention and quality of life in adult oncology patients. Clin Nutr 2007; 26(3): 289-301.

Ritbun N, Wongchomphu N. Nutrition status of breast cancer in patient in Maharaj Nakorn chiangmai. Hospital. Chiangmai university 2011. Available from: faculty/pharmacy/upfile_soure/PT1055.pdf

Chaiveerawatana A, Sukornyotin S, Koraluck A, et al. Guideline for diagnosis and treatment lung cancer. Bangkok: Prapudsadsanahangchad Publiser; 2009. Available from:

Van Cutsem E, Areds J. The causes and consequences of cancer-associated malnutrition. Eur J Oncol Nur 2005; 9(Suppl 2): S51-S63.

Beck AM, Ovesen L. At which body mass index and degree of weight loss should hospitalized elderly patients be considered at nutritional risk? Clin Nutr 1998; 17(5): 195-8.

Gioulbasanis I, Baracos VE, Giannousi Z, et al. Baseline nutritional evaluation in metastatic lung cancer patients: Mini Nutritional Assessment versus weight loss history. Ann Oncol 2011; 22(4): 835-4.

Silander E, Nyman J, Hammerlid E. An exploration of factors predicting malnutrition in patients with advanced head and neck cancer. The Laryngoscope 2013; 123(10): 2428-34.

Nicolini A, Ferrari P, Masoni MC, et al. Malnutrition, anorexia and cachexia in cancer patients: A mini-review on pathogenesis and treatment. Biomed Pharmacother 2013; 67(8): 807-17.

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Copyright (c) 2019 Buntitabhon Sirichancheun , Jantanee Thanomsakcharoen , Piyanuch Intakut , Yaowapan Kaewpan  , Chuleegone Sornsuvit