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In Vitro Dissolution Interference Study in Presence of Paracetamol Tablets with Freshly Prepared Mango Juices on Simulated Gastrointestinal Digestion

Authors

  • Md. Didaruzzaman Sohel

    State University of Bangladesh, Dhaka-1205, Bangladesh

  • Faisal Asif

    State University of Bangladesh, Dhaka-1205, Bangladesh

  • Md. Helal Uddin Sumon

    NIPRO JMI Pharma Ltd. Rajendrapur, Chauddagram, Comilla, Bangladesh

  • Kaniz Fatema  

    State University of Bangladesh, Dhaka-1205, Bangladesh

  • Md. Hassan Kawsar

    State University of Bangladesh, Dhaka-1205, Bangladesh

DOI:

https://doi.org/10.29169/1927-5951.2020.10.04.4

Keywords:

Paracetamol, Drug Interactions, Mango Juice, Bangladesh.

Abstract

This study is performed beneath In Vitro dissolution applying various mathematical approaches to observe the dissolution interference on simulated gastrointestinal digestion. In total, eight medicine samples wereollected in Bangladeshi market and the conventional approaches were followed to measure the result in gastric medium (pH 1.2). Altogether, the brands showed sensibly upper dissolution discharge; primarily P01 (98.9%), P08 (98.97%), P03 (98.32%) and P06 (98.24%) were released relatively faster than the other sample in 15 to 60 minutes. Along with the mango juice in the simulated gastric medium, the brands showed sensibly upper dissolution discharge; primarily P01 (98.83%), P07 (98.98%), P06 (98.78%) and P03 (98.38%) were released relatively faster than the other sample in 15 to 60 minutes. This result depicts to understand the proper release of kinetics with the help of various mathematical model such as Zero order, First order, Higuchi and Hixson-Crowell model etc. although Paracetamol can interact with the fruit juices, which may alter the drug release, drug absorption in the body and may also lead to an unwanted reaction.

References

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Published

2020-08-05

Issue

Vol. 10 No. 4 (2020)

Section

Articles

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Copyright (c) 2020 Md. Didaruzzaman Sohel , Faisal Asif , Md. Helal Uddin Sumon , Kaniz Fatema  , Md. Hassan Kawsar

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

In Vitro Dissolution Interference Study in Presence of Paracetamol Tablets with Freshly Prepared Mango Juices on Simulated Gastrointestinal Digestion. (2020). Journal of Pharmacy and Nutrition Sciences , 10(4), 148-154. https://doi.org/10.29169/1927-5951.2020.10.04.4

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