Gardenia volkensii K. Schum. (Rubiaceae): Review of Medicinal uses, Phytochemistry and Biological Activities


 Gardenia volkensii, ethnopharmacology, herbal medicine, indigenous pharmacopeia, Rubiaceae.

How to Cite

Alfred Maroyi. (2020). Gardenia volkensii K. Schum. (Rubiaceae): Review of Medicinal uses, Phytochemistry and Biological Activities. Journal of Pharmacy and Nutrition Sciences, 10(5), 175–181.


Gardenia volkensii K. Schum. is a shrub or small tree widely used as traditional medicine throughout its distributional range in tropical Africa. This study is aimed at providing a critical review of the medicinal uses, phytochemistry and biological activities of G. volkensii. Documented information on the medicinal uses, phytochemistry and biological activities of G. volkensii was collected from several online sources, which included Scopus, Google Scholar, PubMed and Science Direct. Additional information was gathered from pre-electronic sources such as book chapters, books, journal articles and scientific publications sourced from the university library. The articles published between 1972 and 2020 were used in this study. This study showed that the species is widely used as emetic and protective charm, and as traditional medicine for infertility, sore eyes, sexually transmitted infections, headache, gastro-intestinal infections, earache, convulsions, epilepsy and respiratory infections. Phytochemical compounds identified from the species include aldehydes, benzenoids, cinnamates, coumarins, essential oils, fatty acids, flavonoids, iridoids, phenolics, phytosterols and triterpenoids. Pharmacological research revealed that G. volkensii extracts and compounds isolated from the species have antibacterial, antifungal, antioxidant, mutagenic and antimutagenic and cytotoxicity activities. Future research on G. volkensii should focus on detailed phytochemical evaluations including toxicological, in vivo and clinical studies to corroborate the traditional medical applications of the species.


Wong KM, Low YW. A revision of Philippine Gardenia (Rubiaceae). Edinburgh J Bot 2011; 68: 11-32.

Govaerts R, et al. World Checklist of Rubiaceae. Richmond: Royal Botanic Gardens, Kew; 2011.

Palmer E, Pitman N. Trees of southern Africa covering all known indigenous species in the Republic of South Africa, South-West Africa, Botswana, Lesotho and Swaziland. Cape Town: Balkema; 1972.

Schmidt E, Lotter M, McCleland W. Trees and shrubs of Mpumalanga and Kruger National Park. Johannesburg: Jacana Media; 2017.

Verdcourt B. Notes on African Gardenia (Rubiaceae). Kew Bull 1979; 34(2): 345-360.

Bridson DM, Verdcourt B. Rubiaceae part 2. In Polhill RM (Ed.), Flora of Tropical East Africa. Rotterdam: Balkema; 1988, pp. 1-355.

Bridson DM, Verdcourt B. Rubiaceae. In Pope GV (Ed.), Flora Zambesiaca 5 part 3. Richmond: Royal Botanic Gardens, Kew, 2003; pp. 671-674.

Germishuizen G, Meyer NL. Plants of southern Africa: An annotated checklist. Pretoria: Strelitzia 14, National Botanical Institute; 2003.

Drummond RB. A list of trees, shrubs and woody climbers indigenous or naturalised in Rhodesia. Kirkia 1975; 10(2): 229-85.

Da Silva MC, Izidine S, Amude AB. A preliminary checklist of the vascular plants of Mozambique. Pretoria: Southern African Botanical Diversity Network Report No. 30; 2004.

Loffler L, Loffler P. Swaziland Tree Atlas: Including selected shrubs and climbers. Pretoria: Southern African Botanical Diversity Network Report No. 38; 2005.

Phiri PSM. A checklist of Zambian vascular plants. Pretoria: Southern African Botanical Diversity Network Report No. 32; 2005.

Setshogo MP. Preliminary checklist of the plants of Botswana. Pretoria: Southern African Botanical Diversity Network Report No. 37; 2005.

Strugnell AM. A checklist of the spermatophytes of Mt. Mulanje, Malawi. Scripta Bot Belg 2006; 34: 1-199.

Van Wyk B, Van Wyk P. How to identify trees in southern Africa. Cape Town: Struik Nature; 2007.

Figueiredo E, Smith GF. Plants of Angola. Pretoria: Strelitzia 22, South African National Biodiversity Institute; 2008.

Mannheimer CA, Curtis BA. Le Roux and Müller's field guide to the trees and shrubs of Namibia. Windhoek: Macmillan Education Namibia; 2009.

Thomas V, Grant R. Sappi tree spotting: KwaZulu-Natal and Eastern Cape. Johannesburg: Jacana Media (Pty) Ltd; 2013.

Burrows JE, et al. Trees and shrubs of Mozambique. Cape Town: Publishing Print Matters (Pty); 2018.

Dharani, N. Field guide to common trees and shrubs of East Africa. Cape Town: Struik Nature; 2019.

Long C. Swaziland’s flora: siSwati names and uses. Mbambane, Swaziland: Swaziland National Trust Commission; 2005. Available at: index.asp, accessed on 14 June 2020.

Heath A, Heath R. Field guide to the plants of northern Botswana including the Okavango Delta: Useful in countries and geographical areas adjacent to northern Botswana in the Zambesi Basin. London: Kew Publishing, Royal Botanic Gardens, Kew; 2009.

Botha J, Weiersbye IM. Ethnobotanic and forage uses of plants on mine properties in the Witwatersrand basin gold fields, South Africa. In Fourie A, Tibbett M, Wiertz J (Eds.). Mine closure. Perth: Australian Centre for Geomechanics; 2010, pp. 325-342.

Venter F, Venter J-A. Making the most of indigenous trees. Pretoria: Briza Publications; 2015.

Coppock DL. The Borana plateau of southern Ethiopia: Synthesis of pastoral research, development and change, 1980-1991. Addis Ababa: International Livestock Centre for Africa; 1994.

Alemayehu G, Asfaw Z, Kelbessa E. Plant diversity and ethnobotany in Berehet District, North Shewa Zone of Amhara Region (Ethiopia) with emphasis on wild edible plants. J Med Plants Stud 2015; 3(6): 93-105.

Ribeiro A, et al. Ethnobotanical survey in Canhane village, district of Massingir, Mozambique: medicinal plants and traditional knowledge. J Ethnobiol Ethnomed 2010; 6: 33.

Cunningham AB. African medicinal plants: Setting priorities at the interface between conservation and primary health care. Paris: People and Plants working paper 1, UNESCO, 1993.

Williams VL, Balkwill K, Witkowski ETF. A lexicon of plants traded in the Witwatersrand umuthi shops, South Africa. Bothalia 2001; 31(1): 71-98.

Steyn H. Gardenia volkensii K. Schum. National Herbarium, Pretoria; 2010., accessed on 5 May 2020.

Maundu P, et al. Ethnobotany of the Loita Maasai: Towards community management of the forest of the lost child experiences from the Loita Ethnobotany project. Paris: People and Plants Working Paper 8, UNESCO 2001.

Motlhanka DMT, Nthoiwa GP. Ethnobotanical survey of medicinal plants of Tswapong North, in eastern Botswana: A case of plants from Mosweu and Seolwane villages. European J Med Plants 2013; 3(1): 10-24.

Urso V, et al. Wild medicinal and food plants used by communities living in Mopane woodlands of southern Angola: Results of an ethnobotanical field investigation. J Ethnopharmacol 2016; 177: 126-139.

Chinsembu KC, Syakalima M, Semenya SS. Ethnomedicinal plants used by traditional healers in the management of HIV/AIDS opportunistic diseases in Lusaka, Zambia. S Afr J Bot 2019; 122: 369-384.

Kigen G, et al. Ethnomedicinal plants traditionally used by the Keiyo community in Elgeyo Marakwet county, Kenya. J Biod Bioprospecting Develop 2014; 1(3): 11.

Ochwang’i DO, et al. Medicinal plants used in treatment and management of cancer in Kakamega County, Kenya. J Ethnopharmacol 2014; 151: 1040-1055.

Gelfand M, et al. The traditional medical practitioner in Zimbabwe: His principles of practice and pharmacopoeia. Gweru: Mambo Press; 1985.

Beentje HJ. Kenya trees, shrubs and lianas. Nairobi: National Museums of Kenya; 1994.

Hutchings A, et al. Zulu medicinal plants: An inventory. Pietermaritzburg: University of Natal Press; 1996.

Sibandze GF. Pharmacological properties of Swazi medicinal plants. MSc Dissertation. University of the Witwatersrand, Johannesburg; 2009.

Setshego MV, et al. Natural resources used as folk cosmeceuticals among rural communities in Vhembe district municipality, Limpopo province, South Africa. BMC Compl Med Therapies 2020; 20: 81.

Kinuthia EW, et al. Constituents of Kenyan Gardenia volkensii. Nat Prod Comm 2012; 7(1): 13-14.

Kinuthia EW, Mwangi EM, Cheplogoi PK. Screening for antimicrobial compounds in Gardenia volkensii fruits (Rubiaceae). Int J Sci Engin Res 2013; 4(4): 1253-1256.

Bolten C. 1998. Healing knowledge and cultural practices in a modern Tswana village. MSc Dissertation. Massachusetts: Williams College; 1998.

Palgrave MC. Keith Coates Palgrave trees of southern Africa. Cape Town: Struik Publishers; 2002.

Kokwaro JO. Medicinal plants of East Africa. Nairobi: University of Nairobi Press; 2009.

Kigen G, et al. Ethnopharmacological survey of the medicinal plants used in Tindiret, Nandi county, Kenya. Afr J Trad Compl Alt Med 2016; 13(3): 156-168.

Amusan OOG, et al. Some herbal remedies from Manzini region of Swaziland. J Ethnopharmacol 2002; 79: 109-112.

Conde P, et al. The botanic mission to Mozambique (1942- 1948): Contributions to the knowledge of the medicinal flora of Mozambique. História Ciências Saúde Manguinhos Rio de Janeiro 2014; 21: 2.

Chinsembu KC, Hijarunguru A, Mbangu A. Ethnomedicinal plants used by traditional healers in the management of HIV/AIDS opportunistic diseases in Rundu, Kavango East region, Namibia. S Afr J Bot 2015; 100: 33-42.

Pakia M, Cooke JA. The ethnobotany of the Midzichenda tribes of the coastal forest areas in Kenya: 2. Medicinal plant uses. S Afr J Bot 2003; 69(3): 382-395.

Van Wyk B, Van Wyk P. Field guide to trees of southern Africa. Cape Town: Struik Nature; 2013.

Rodin RJ. The ethnobotany of the Khanyama Ovambos. Kansas: Allen Press Inc.; 1985.

Hedberg I, Staugård F. Traditional medicine in Botswana: Traditional medicinal plants. Gaborone: Ipelegeng Publishers; 1989.

Mongalo NI, Makhafola TJ. Ethnobotanical knowledge of the lay people of Blouberg area (Pedi tribe), Limpopo province, South Africa. J Ethnobiol Ethnomed 2018; 14: 46.

Danley K. Letters of the bush: A case study of traditional Setswana herbal medicine. Independent Study Project (ISP) Collection 270; 2006. Available from:, accessed on 25 May 2020..

Jeruto P, et al. An inventory of medicinal plants used to treat gynaecological obstetric-urino-genital disorders in south Nandi Sub county in Kenya. J Nat Sci Res 2015; 5(18): 136-152.

Bekele-Tesemma A. Useful trees and shrubs for Ethiopia: Identification, propagation and management for 17 agroclimatic zones. Nairobi: Technical Manual No 6, RELMA; 2007.

Mabogo DEN. The Ethnobotany of the VhaVenda. MSc Dissertation. Pretoria: University of Pretoria; 1990.

Peter R. Phytochemical Investigation and biological activity studies of Gardenia volkensii. MSc Dissertation. Gaborone: University of Botswana; 2004.

Juma BF, Majinda RRT. Constituents of Gardenia volkensii: Their brine shrimp lethality and DPPH radical scavenging properties. Nat Prod Res 2007; 21(2): 121-125.

Suwannakud KS, et al. Chemical constituents of medicinal plants, Gardenia elata, G. gjellerupii, and G. volkensii. Int J Pharmacogn Phytochem Res 2017; 9(3); 293-296.

Mutta DN. Antibiotic screening of plants used to treat infectious diseases in Kenya. MSc Dissertation. Vancouver: University of British Columbia 1995.

Elgorashi EE, et al. The use of plants in traditional medicine: Potential genotoxic risks. S Afr J Bot 2002; 68: 408-410.

Taylor JLS, et al. Investigating the safety of plants used in south African traditional medicine, testing for genotoxicity in the micronucleus and alkaline Comet assays. Environ Mol Mutagen 2003; 42: 144-154.

Verschaeve L, et al. Investigation of the antimutagenic effects of selected South African medicinal plant extracts. Toxicol Vitro 2004; 18: 29-35.

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