Pioglitazone Ameliorates Lipid Metabolic Disorder in KKAy Mice


  • Sifan Chen Sun Yat-Sen University, Guangzhou, China
  • Qing Wei Sun Yat-Sen University, Guangzhou 510080, PR China
  • Yanshuang Sun Sun Yat-Sen University, Guangzhou, China
  • Xincai Xiao Sun Yat-Sen University, Guangzhou, China
  • Zili Zhang Sun Yat-Sen University, Guangzhou, China
  • Liangru Ke Sun Yat-Sen University, Guangzhou, Guangdong, People’s Republic of China
  • Niman Zhou Sun Yat-Sen University, Guangzhou, Guangdong, People’s Republic of China
  • Zhiming Shan Sun Yat-Sen University, Guangzhou, Guangdong, People’s Republic of China
  • Xiang Feng Sun Yat-Sen University, Guangzhou, China
  • Wei Zhu Guangzhou Center for Disease Control and Prevention, Guangzhou, Guangdong, People’s Republic of China




 Pioglitazone, lipid metabolic disorder, AMP-activated protein kinase.


Pioglitazone (pio) has been used as an effective hypoglycemic drug in medicine, however, the effects and mechanisms of pio on lipid metabolic disorder are still largely unknown. To explore the effects of pio on serum and liver lipid level and antioxidant ability of mice with lipid metabolic disorder, KKAy mice were treated with piofor 12 weeks and their lipid and antioxidant indices were compared to those of KKAy mice without pio treatment. C57BL/6J mice were used as control animals. The results show that pio treatment reduces serum and liver TG, elevates serum HDL-C level, increases serum and liver SOD activity, attenuates serum MDA content, ameliorates liver steatosis, induces liver PPARγexpression and enhances AMPKα phosphorylation level. In conclusion, the results indicate that pio could regulate blood lipid level, reduce liver lipid deposition and enhance antioxidant capacity of mice with lipid metabolic disorder, which is possibly through increasing AMPKα phosphorylation.


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How to Cite

Sifan Chen, Qing Wei, Yanshuang Sun, Xincai Xiao, Zili Zhang, Liangru Ke, Niman Zhou, Zhiming Shan, Xiang Feng, & Wei Zhu. (2011). Pioglitazone Ameliorates Lipid Metabolic Disorder in KKAy Mice . Journal of Pharmacy and Nutrition Sciences, 1(2), 140–146. https://doi.org/10.6000/1927-5951.2011.01.02.09