Dissolution Profiles of Lanoxin Tablets in Media Supplemented with Soluble and Insoluble Forms of Fiber


 Digoxin, psyillium husk, dextrin, cellulose, dissolution hinderance.

How to Cite

Michael A. Sandoval, Hugh D. Smyth, & Jason T. McConville. (2011). Dissolution Profiles of Lanoxin Tablets in Media Supplemented with Soluble and Insoluble Forms of Fiber. Journal of Pharmacy and Nutrition Sciences, 1(2), 96–99. https://doi.org/10.6000/1927-5951.2011.01.02.01


Lanoxin (digoxin) is available as 125 µg or 250 µg tablets for oral administration used to treat heart failure and arrhythmias. The objective of this study was to develop and investigate a comparativedissolutionstudy performed on lanoxin tablets in presence of insoluble or soluble forms of fiber. This study was performed to understand possible influence of fiber (psyillium husk, wheat dextrin, or powdered cellulose)on dissolutionof lanoxin in physiological relevant temperature and pH.Dissolutiontesting was performed using a USP dissolution testing apparatus II paddlerotating at 100 r/min, in 600 mL simulated gastric fluid (pH 1.2) which was maintained at (37 +/- 0.5 °C). A floating cellulose dialysis tube was used to collect sampling fractions. Quantification was performed using a developed and validated high performance liquid chromatographic (HPLC) method. Results indicate that the presence of psyillium husk in the dissolution medium hindered digoxin release. Statistical results reveal that the release profiles of digoxin in presence of wheat dextrin or powdered cellulose did not influence drug release.



Welling PG, Effects of food on drug absorption. Annu Rev Nutr 1996; 16: 383–415.


Amidon GL. A theoretical basis for biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability, Pharm Res 1995; 12: 413–20.


Food and Drug Administration, Guidance for Industry: Dissolution Testing of Immediate Release Solid Oral Dosage Forms (FDA, Rockville, MD, August 1997).

Skelly JP, Amidon GL. Barr WH. Benet LZ. Carter JE. Robinson JR. Shah VP. Yacobi A., In vitro and in vivo testing and correlation for oral controlled/modifiedrelease dosage forms/ Pharmaceutical Research 1990; 7: 975-82.


Reppas C. Eleftheriou G. Macheras P. Symillides M. Dressman JB. Effect of elevated viscosity in the upper gastrointestinal tract on drug absorption in dogs. European Journal of Pharmaceutical Sciences 1998; 6: 131–9.


Blackburn NA, Johnson IT, The effect of guar gum on the viscosity of the gastrointestinal contents and on glucose uptake from the perfused jejunum in the rat. Br J Nutr 1981; 46: 239–46.


Dressman JB. Amidon GL. Reppas C. Shah VP. Dissolution testing as a prognostic tool for oral drug absorption: Immediate release dosage forms. Pharm Res 1998; 15: 11Y22.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Copyright (c) 2011 Michael A. Sandoval, Hugh D. Smyth , Jason T. McConville