Fatty Acid Profile in Plasma and Red Blood Cells in Chronic Fatigue Syndrome Patients
DOI:
https://doi.org/10.6000/1927-5951.2011.01.02.02Keywords:
Chronic fatigue syndrome, Essential fatty acids, Docosahexaenoic acid, Eicosapentaenoic acid, w-3 Fatty acids.Abstract
Chronic Fatigue Syndrome is an illness of unknown aetiology that has been associated with abnormalities in essential fatty acid metabolism, however this still remains unclear. We have compared the fatty acid profile in plasma and red blood cells and their dietary intake between a group of 20 patients diagnosed with CFS (18 women and 2 men) and 20 aged- sex- diet- low activity- matched controls. Compared to the controls, CFS patients show a decrease in the proportion of linoleic acid (t: 2.137, p: 0.039) and an increase in that of stearic acid (t: 2.602, p: 0.013) in plasma, however such differences have not been observed in the fatty acid profile of red blood cells. In these cases, no direct relationship has been observed between the dietary intake and fatty acid profile. Therefore, these results do not give support that long-chain polyunsaturated fatty acids may contribute in the better course of the pathology.
References
Fukuda K, Straus S, Hickie I. The chronic fatigue síndrome: a comprehensive approach to its definition and study. Ann Intern Med. 1994; 121: 953-9.
Simopoulos A P. Essential fatty acids in health and chronic disease. Am J Clin Nutr. 1999; 70 (suppl): 560s-9s.
Simopoulos A P. Omega 3 fatty acids in inflammation and autoimmune diseases. J Am Col Nutr. 2002; 21 : 495-505.
Lefkowith J B, Morrison A, Lee V, Rogers M. Manipulation of acute inflammatory response by dietary polyunsaturated fatty acid modulation. The Journal of Immunology. 1990; 145: 1523-9.
Mantzioris E, Cleland L G, Gibson R A, Neumann M A, Demasi M, James M J. Biochemical effects of a diet containing foods enriched with n-3 fatty acids. Am J Clin Nutr. 2000; 72: 42-8.
Simmopoulos A P. The importance of the ratio of omega-6/omega-3 essential fatty acids Biomed Pharmacother. 2002; 56: 365-79.
http://dx.doi.org/10.1016/S0753-3322(02)00253-6
Haag M. Essential fatty acids and the brain. Can J Psychiatry. 2003; 48: 195-203.
Tamizi Bfar, Tamizi B. Treatment of chronic fatigue syndrome by dietary supplementation with w-3 fatty acids-a good idea? Medical Hypotheses. (2002) 58(3), 249-50.
http://dx.doi.org/10.1054/mehy.2001.1507
Puri B K, Holmes J, Hamilton G. Eicosapentaenoic acid-rich essential fatty acid supplementation in chronic fatigue syndrome associated with symptom remission and structural brain changes. Int J Clin Pract. 2004; 58: 297-9.
http://dx.doi.org/10.1111/j.1368-5031.2004.00073.x
Puri BK. The use of eicosapentaenoic acid in the treatment of chronic fatigue syndrome. Prost Leu Essent Fatty Acids. 2004; 70: 399-401.
http://dx.doi.org/10.1016/j.plefa.2003.12.015
Behan P O, Behan W M H, Horrobin D F. Effect of high doses of essential fatty acids on the postviral fatigue syndrome. Acta Neurol Scand. 1990; 82: 209-16.
http://dx.doi.org/10.1111/j.1600-0404.1990.tb04490.x
Liu Z, Wang D, Xue Q, Chen J, Li Y, Bai X, Chang L. Determination of Fatty Acid Levels in Erythrocyte Membranes of Patients with Chronic Fatigue Syndrome. Nutr Neuro. 2003; 6: 389-92.
http://dx.doi.org/10.1080/10284150310001640356
Maes M, Mihaylova I, Leunis JC. In chronic fatigue syndrome, the decreased levels of omega-3 poly-unsaturated fatty acids are related to lowered serum zinc and defects in T cell activation. Neuro Endocrinol Lett. 2005 Dec;26(6):745-51.
Puri BK. Long-chain polyunsaturated fatty acids and the pathophysiology of myalgic encephalomyelitis (chronic fatigue syndrome). Review. J Clin Pathol. 2007; 60: 122-4.
http://dx.doi.org/10.1136/jcp.2006.042424
Warren G, McKendrick M, Peet M. The role of essential fatty acids in chronic fatigue syndrome: a case-controlled study of red cell membrane essential fatty acids (EFA) and a placebo-controlled treatment study with high dose of EFA. Acta Neurol Scand. 1999; 99: 112-6.
http://dx.doi.org/10.1111/j.1600-0404.1999.tb00667.x
Li YJ, Wang DX, Bai XL, Chen J, Liu ZD, Feng ZJ, Zhao YM. Clinical characteristics of patients with chronic fatigue syndrome: analysis of 82 cases. Zhonghua Yi Xue Za Zhi. 2005 Mar 16;85(10):701-4.
FAO/WHO-OMS/UNU Expert consultation report. Energy and Protein Requirements. Technical Report Series 724. Ginebra: WHO/OMS. 1985.
Tamizi far B, Tamizi B. Treatment of chronic fatigue syndrome by dietary supplementation with w-3 fatty acids – a good idea? Med Hypotheses. 2002; 58: 249-50.
Gray J B, Martinovic A M. Eicosanoids and essential fatty acid modulation in chronic disease and the chronic fatigue syndrome. Med Hypotheses. 1994; 43: 31-42.
Downloads
Published
Issue
Section
License
Copyright (c) 2011 Ramon Segura, Casimiro Javierre, Magda Rafecas, Josep L Ventura, Laura Arranz, Gemma Miranda
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
Similar Articles
- Kaya Bulut Gulsen, Ozgultekin Asu, Turan Guldem, Isıtmangil Gulbu, Terzioglu Ufuk, Kurt Nurettin , Ekinci Osman, Investigation for the Effects of Omega Fatty Acid and Glutamine-L-Alanine on Morbidity and Mortality in the Critically ILL Patients after Major Abdominal Surgery , Journal of Pharmacy and Nutrition Sciences : Vol. 4 No. 2 (2014)
- Jamaluddin, Ayu Putu Putriasih, Yonelian Yuyun , Agustinus Widodo, The Comparison Extraction Methods of Crude Fat Content and Fatty Acid Profile of Eels (Anguilla marmorata (Q.) Gaimard) from Lake Poso , Journal of Pharmacy and Nutrition Sciences : Vol. 9 No. 2 (2019)
- Ken Yasukawa, Linoleic Acid Blocks the Inhibitory Effects of Caffeine on Tumour Promotion by 12-O-Tetradecanoylphorbol-13-Acetate in Two-Stage Carcinogenesis in Mouse Skin , Journal of Pharmacy and Nutrition Sciences : Vol. 5 No. 3 (2015)
- Jamaluddin, Cindra Rusli, Yonelian Yuyun , Agustinus Widodo, Comparative Study of Fish Eel Amino Acid Profile (Anguilla marmorata (Q.) Gaimard) on Silver eel Phase from Palu River and Poso Lake , Journal of Pharmacy and Nutrition Sciences : Vol. 9 No. 2 (2019)
- Nwogo Ajuka Obasi, Chinyere Aloke, Stella Eberechukwu Obasi, Ademola Clement Famurewa, Sunday Oge Elom, Patrck Maduabuchi Aja, Lawrence Olusegun Ajala, Nutritional Assessment of Pulps and Partial Characterization of Seed Oils from Varieties of Pear Fruits , Journal of Pharmacy and Nutrition Sciences : Vol. 13 (2023)
- Jamaluddin, Nur Atina , Yonelian Yuyun, The Analysis of Protein Level and Amino Acid Profile in Eels (Anguilla marmorata (Q.) Gaimard and Anguilla bicolor) of Lake Poso , Journal of Pharmacy and Nutrition Sciences : Vol. 9 No. 1 (2019)
- Alfred Maroyi, Traditional Uses, Phytochemical and Pharmacological Properties of Dovyalis caffra , Journal of Pharmacy and Nutrition Sciences : Vol. 8 No. 4 (2018)
- A.F. Ogundola, T.A. Yekeen, R.A. Arotayo, A.O. Akintola, A.O. Ibrahim, H.O. Adedosu, M.O. Bello, Evaluation of Nutrients in Leaves and Seeds of Calotropis Procera (linn) , Journal of Pharmacy and Nutrition Sciences : Vol. 11 (2021)
- Denis Kiragu, Raymond L. Tyohemba, Ogbene G. Igbum, Michael Nase, GC/MS Profiling and Antibacterial Activity of Steam-Distilled Solanecio mannii Essential Oil and Hydrosol Against Multidrug-Resistant Food Pathogens , Journal of Pharmacy and Nutrition Sciences : Vol. 15 (2025)
- Alfred Maroyi, Centrapalus pauciflorus: Review of its Medicinal uses, Phytochemistry and Pharmacological Properties , Journal of Pharmacy and Nutrition Sciences : Vol. 10 No. 5 (2020)
You may also start an advanced similarity search for this article.