Abstract
Natural products, especially those derived from higher plants, have attracted scientists from ancient time because of their potential therapeutic values. Drug development from natural sources showed that natural products or natural product-derived drugs comprised about 28% of all new chemical entities launched to the market. These are originated from terrestrial plants, microbes, marine organisms, etc. However, until recently an insignificant part of the plants has been scientifically evaluated for their medicinal properties. Bangladesh is a rich repository of medicinal plants, many of which are widely used in the Ayurvedic, Unani, herbal and other traditional systems of medicines. In our laboratory, we have extensively investigated over 48 medicinal plants and several microbial strains that have resulted in the isolation and characterization of 133 compounds, including 33 new molecules. Terpenoids, alkaloids, flavonoids and glycosides were the major classes of constituents. The crude extractives and several purified molecules demonstrated statistically significant inhibition of growth of microorganisms. On the other hand, usnic acid obtained from the lichen, Parmelia kamtschandalis, demonstrated even better of inhibition of microbial growth as compared to the standard antimicrobial agents, whereas dehydroaltenusin extracted from a Streptomyces sp. exhibited significant HIV-inhibitory activity.
References
Chowdhury, R., Hasan, CM. and Rashid, MA. 2003. Guaiane Sesquiterpenes from Amoora rohituka. Phytochemistry. 62: 1213-1216.
Farruque, R., Chowdhury, R., Sohrab, MH., Hasan, CM. and Rashid, MA. 2003. Triterpene constituents from the leaves of Melicope indica. Pharmazie. 58: 518-520.
Hasan, CM., Shahanz, S., Ilias, M., Gray, AI. and Waterman, PG. 1987. Chemistry in the Annonaceae, XXIII. 24- Methylene-lanosta-7,9(11)-dien-3β-ol from Artabotrys odorotissimus stem bark. J. Nat. Prod. 50:762-763.
Connolly, JD., Hoque, ME., Hasan, CM. and Haider, SS. 1994. Constituents of the stem bark of Artabotrys odoritissimus. Fitoterapia. 65: 92-93.
Hasan, CM., Hossain, MA. and Rashid, MA. 1995. Clerodane diterpenoids from Polyalthia longifolia var. pendulla. Biochem. Syst. Ecol. 23: 331-332.
Chowdhury, R., Rashid, RB., Sohrab, MH., Hasan, CM. 2003. 12α-hydroxystigmast-4-en-3-one: a new bioactive steroid from Toona ciliata (Meliaceae). Pharmazie. 58: 272- 273.
Hasan, CM., Islam, A., Ahmed, M., Ahmed, MU. and Waterman, PG. 1984. Capsugenin, a dammarane triterpene from Corchorus capsularis. Phytochemistry. 23: 2583-2587.
Quader, MA., Ahmed, MU., Hasan, CM. and Waterman, PG. 1987. A new glycoside from the leaves of Corchorus capsularies. J. Nat. Prod. 50: 479-481.
Huq, MM., Jabbar, A., Rashid, MA., Hasan, CM. 1999. A novel antibacterial and cardiac steroid from the roots of Nerium oleander. Fitoterapia. 70: 5-9.
Huq, MM., Jabbar, A., Rashid, MA., Hasan, CM., Ito C. and Furukawa H. 1999.Steroids from the roots of Nerium oleander. J. Nat. Prod. 62: 1055-1057.
Hasan, CM., Khan, S., Jabbar, A. and Rashid, MA. 2000. Two novel neo- clerodane diterpenes from Barringtonia recemosa. J. Nat. Prod. 63: 411-412.
Hasan, CM., Huda, Q., Lavaud, C., Connolly, JD. and Huq, ME. 1995. Bengalensol, A new 16-epicafestol derivative from the leaves of Coffea bengalensis. Nat. Prod. Lett. 4: 55-60.
Sohrab, MH., Hasan, CM. and Rashid, MA. 1999. Lunamarins A and B: two novel terpenoid coumarins from Clausena heptaphylla. Nat. Prod. Lett. 14: 47 53.
Sohrab, MH., Begum, B., Hasan, CM. and Rashid, MA. 1999. Antimicrobial screening of the leaf of Micromelum pubescens. Bangladesh J Med Microbiol. 16: 203-205.
Jumana, S., Hasan, CM. and Rashid, MA. 2000. (+) Isocorydine-α-N-oxide : A new aporphine alkaloid from M.velutina. Nat. Prod. Lett. 14: 393-397.
Nutun, MTH., Hasan, CM. and Rashid, MA. 1999. Bismurrayafoline E : a new dimeric carbazole alkaloid from Murraya koenigii. Fitoterapia. 70: 130 -133.
Hasan, CM., Mia, MY. and Rashid, MA. 1996. A new acetogenin from Goniothalamus sesquipedalis (Annonaceae). Dhaka Univ. J. Biol. Sci. 5: 99-102.
Hasan, CM., Mia, MY., Rashid, MA. and Connolly JD. 1994. 5-Acetoxyisogoniothalamin oxide, a new epoxystyryl lactone from Goniothalamus sesquipedalis (Annonaceae). Phytochemistry. 37: 1763 -1764.
Rahman, MS., Chowdhury, R., Begum, B., Rahman, KM. and Rashid, MA. 2005. Phytochemical studies of Amoora cucullata. The Dhaka Univ. J. Pharm. Sci. 4: 73-75.
Haque, MR., Rahman, KM., Iskander, MN., Hasan, CM. and Rashid, MA. 2006. Stereochenols A and B, two quinones from Stereospermum chelonoides. Phytochemistry. 67: 2663- 2665.
Rahman, MS., Chowdhury, R., Hasan, CM. and Rashid, MA. 2006. Oleanane Glycosides from Eclipta prostrata. The Dhaka Univ. J. Pharm. Sci. 4: 107-111.
Khan, MSH., Nahar, N., Mosihuzzaman, M., and Rashid, MA. 2003. Three megastigmane glycosides from the leaves of Pterospermum semisagittatum. Pharm. Biol. 41: 11-15.
Qais, N., Mandal, MR., Rashid, M.A., Jabbar, A., Koshino, H., Nagasawa and Nakata, T. 1998. A furanoid labdane diterpene from Potamogeton nodusus. J. Nat. Prod. 61: 156-157.
Ara, K., Rahman, AHMM., Hasan, CM., Iskander, MN., Asakawa, Y., Quang, DN. and Rashid, MA. 2006. Macrocyclic diarylheptanoids from Garuga pinnata. Phytochemistry. 67, 2659-2662.
Rashid, MA., Bhuiyan, MSA., Hossain, MA., Quader, MA., Nutan, MTH., and Karim, MR. 2001. (+)- Usnic acid, An antimicrobial agent from Permelia kamtschandalis. Pak. Jour. of Mic. 1(1): 26-28.
Jabbar, A. Shresta, AP., Hasan, CM. and Rashid, MA. 1999. Anti-HIV activity of Dehydroaltenusin- a metaboite from a steptomyces sp. Nat. Prod. Sci. 5(4): 162-164.
Rahman, S., Hasnat, A., Hasan, CM., Rashid, MA. and Ilias, M. 2001. Pharmacological evaluation of Bangladeshi medicinal plants – a review. Pharm. Biol. 39: 1-6.
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