Muscular Hypertrophic Effects of Oral Contraceptive Consumption in Women
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Keywords

Contraceptive
exercise
hypertrophy

How to Cite

Pinheiro, J. A. R., da Silva, L. A., Weber, V. M. R., Malfatti, C. R. M., & Brasil, M. R. (2023). Muscular Hypertrophic Effects of Oral Contraceptive Consumption in Women. Journal of Pharmacy and Nutrition Sciences, 13, 75–81. https://doi.org/10.29169/1927-5951.2023.13.08

Abstract

Hormones have several actions in the body; among their effects on effector organs, they can control the volume of skeletal muscle. The excess of hormones, in this case exogenous ones, could be altering the effects of physical exercise on skeletal muscle hypertrophy, especially after the consumption of contraceptives. Thus, we have a general objective in this work to evaluate the effects of contraceptive consumption on hypertrophy in women. We sought an integrative literature review with studies within 2001-2021, using the PubMed and Scielo databases. Seven articles were selected for a complete and coherent reading for the development of this review. Given the studies analyzed in the present study, it was possible to observe that the effects of oral contraceptives may indeed influence muscle hypertrophy. However, it can assist in preserving soft tissues, avoiding the looseness of the anterior cruciate ligament (ACL). For individuals aiming to enhance lean muscle mass, particularly in high-performance contexts, it is advisable to consider alternative contraceptive methods that do not disrupt the natural hormonal system. In conclusion, the OC user group did not obtain significant gains in lean mass, but their levels of dehydroepiandrosterone (DHEA), sex hormone agglobulinal ligand (SHBG), and insulin-like growth factor (IGF1) decreased, with increasing levels of only cortisol. Thinking of high performance to increase lean muscle mass, another means of contraceptives that do not affect the physiological hormonal system should be used.

https://doi.org/10.29169/1927-5951.2023.13.08
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References

Mansour D, Inki P, Gemzell-Danielsson K. Efficacy of contraceptive methods: a review of the literature. The European Journal of Contraception & Reproductive Health Care 2010; 15(1): 4-16. https://doi.org/10.3109/13625180903427675

Guyton. Guyton and Hall Textbook of Medical Physiology. Philadelphia, PA: Saunders Elsevier 2011.

Morais R, Medeiros RR, Liberali R. Effectiveness of the supplementation of proteins in the training of force. Revista Brasileira de Nutrição Esportiva 2008; 2(10): 265-277.

Shangold MM. Exercise and the AdultFemale: Hormonal and Endocrine Effects. Exerciseand Sport Sciences Reviews 1984; 12(1): 53-80. https://doi.org/10.1249/00003677-198401000-00005

Carr S, Carmody D. Experiential learning in women's health: medical student reflections. Med Educ 2006; 40(8): 768-74. https://doi.org/10.1111/j.1365-2929.2006.02536.x

Alkema L, Kantorova V, Menozzi C, Biddlecom A. National, regional, and global rates and trends in contraceptive prevalence and unmet need for family planning between 1990 and 2015: a systematic and comprehensive analysis. Lancet 2013; 381(9878): 1642-52. https://doi.org/10.1016/S0140-6736(12)62204-1

Schwartz E, Holtorf K. Hormone replacement therapy in the geriatric patient: current state of the evidence and questions for the future. Estrogen, progesterone, testosterone, and thyroid hormone augmentation in geriatric clinical practice: part 1. Clinics in Geriatric Medicine 2011; 27(4): 541-559. https://doi.org/10.1016/j.cger.2011.07.013

Godbole G, Joshi AR, Vaidya SM. Effect of female sex hormones on cardiorespiratory parameters. Journal of Family Medicine and Primary Care 2016; 5(4): 822. https://doi.org/10.4103/2249-4863.201148

Guillebaud J. Drug interactions with hormonal contraception. The Journal of Family Planning and Reproductive Health Care 2005; 31(4): 335-6. https://doi.org/10.1783/147118905774480644

Konopka JA, Hsue LJ, Dragoo JL. Effect of Oral Contraceptives on Soft Tissue Injury Risk, Soft Tissue Laxity, and Muscle Strength: A Systematic Review of the Literature. Orthop J Sports Med 2019; 7(3): 2325967119831061. https://doi.org/10.1177/2325967119831061

Lee CW, Newman MA, Reichman SE. Oral contraceptive use impairs muscle gains in young women. FASEB Journal 2009; 23(1): 955-25. https://doi.org/10.1096/fasebj.23.1_supplement.955.25

Hicks KM, Onambélé-Pearson G, Winwood K, Morse CI. Oral contraceptive pill use and the susceptibility to markers of exercise-induced muscle damage. Eur J Appl Physiol 2017; 117(7): 1393-1402. https://doi.org/10.1007/s00421-017-3629-6

Dalgaard LB, Dalgas U, Andersen JL, Rossen NB, Møller AB, Stødkilde-Jørgensen H, Jørgensen JO, Kovanen V, Couppé C, Langberg H, Kjær M and Hansen M. Influence of Oral Contraceptive Use on Adaptations to Resistance Training. Front Physiol 2019; 10: 824. https://doi.org/10.3389/fphys.2019.00824

Martin D, Elliott-sale K. A perspective on current research investigating the effects of hormonal contraceptives on determinants of female athlete performance. Revista Brasileira de Educação Física e Esporte 2016; 30(4): 1087-1096. https://doi.org/10.1590/1807-55092016000401087

Romance R, Vargas S, Espinar S, Petro JL, Bonilla DA, Schöenfeld BJ, Kreider RB, Benítez-Porres J. Oral Contraceptive Use does not Negatively Affect Body Composition and Strength Adaptations in Trained Women. Int J Sports Med 2019; 40(13): 842-849. https://doi.org/10.1055/a-0985-4373

Onambele GN, Bruce SA, Woledge RC. Oestrogen status in relation to the early training responses in human thumb adductor muscles. Acta Physiol (Oxf) 2006; 188(1): 41-52. https://doi.org/10.1111/j.1748-1716.2006.01597.x

Peters C, Burrows M. Androgenicity of the progestin in oral contraceptives does not affect maximal leg strength. Contraception 2006; 74(6): 487-91. https://doi.org/10.1016/j.contraception.2006.08.005

Badillo JJ, Ayestarán EG. Fundamentos do Treinamento de Força - Aplicação ao Alto Rendimento Desportivo. Porto Alegre: Artmed 2001.

Zimmerman Y, Eijkemans MJ, Coelingh Bennink HJ, Blankenstein MA, Fauser BC. The effect of combined oral contraception on testosterone levels in healthy women: a systematic review and meta-analysis. Hum Reprod Update 2014; 20(1): 76-105. https://doi.org/10.1093/humupd/dmt038

Bermon S, Garnier PY, Hirschberg AL, Robinson N, Giraud S, Nicoli R, Ritzen M. Serum androgen levels in elite female athletes. The Journal of Clinical Endocrinology Metabolism 2014; 99(11): 4328-4335. https://doi.org/10.1210/jc.2014-1391

Glass DJ. Skeletal muscle hypertrophy and atrophy signaling pathways. Int J Biochem Cell Biol 2005; 37(10): 1974-84. https://doi.org/10.1016/j.biocel.2005.04.018

Goldspink G. Gene expression in muscle in response to exercise. J Muscle Res Cell Motil 2003; 24(2-3): 121-6. https://doi.org/10.1023/A:1026041228041

Ferguson B. ACSM’s Guidelines for Exercise Testing and Prescription 9th Ed. 2014. J Can Chiropr Assoc 2014; 58(3): 328.

Dias RMR, Cyrino ES, Salvador EP, Nakamura FY, Pina FLC, Oliveira AR. Impact of an eight-week weight training program on the muscular strength of men and women. Brazilian Journal of Sports Medicine 2005; 11(4): 224-228. https://doi.org/10.1590/S1517-86922005000400004

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Copyright (c) 2023 João Augusto Recliski Pinheiro, Luiz Augusto da Silva, Vinicius Muller Reis Weber, Carlos Ricardo Maneck Malfatti, Marcos Roberto Brasil