Prospective Study on the Effects of Marijuana Smoking on Lipase and Amylase Activities among Adult Nigerians

Mathias A. Emokpae; Samuel A. Afolabi; Charles C. Osiki; Shedrack E. Akor

doi:10.29169/1927-5951.2024.14.04

Prospective Study on the Effects of Marijuana Smoking on Lipase and Amylase Activities among Adult Nigerians

Authors

Mathias A. Emokpae Department of Medical Laboratory Science, School of Basic Medical Sciences, University of Benin, Benin City, Edo State, Nigeria
Samuel A. Afolabi Department of Clinical Chemistry, Faculty of Medical Laboratory Science, Achievers University, Owo, Ondo State, Nigeria
Charles C. Osiki Department of Medical Laboratory Science, School of Basic Medical Sciences, University of Benin, Benin City, Edo State, Nigeria
Shedrack E. Akor Department of Medical Laboratory Science, School of Besic Medical Sciences, College of Health Sciences, Prince Abubakar Audu University, Anyigba, Nigeria

DOI:

https://doi.org/10.29169/1927-5951.2024.14.04

Keywords:

Adult, Marijuana Smoking, Prospective Studies, Amylase, Lipase, Humans, Pancreatitis

Abstract

Marijuana consumption is prevalent among young adults in Nigeria, and its effects on various physiological systems are of growing concern. This study investigates the impact of marijuana use on digestive enzymes, specifically serum amylase and lipase, to understand its potential implications on digestive health. This cross-sectional study was conducted in 120 participants comprising of 60 marijuana smokers and 60 non-smokers. Sociodemographic and lifestyle data were collected through structured questionnaires. Serum amylase and lipase activity levels were measured by spectrophotometric method and compared between the two groups. Statistical analysis was performed to assess differences and correlations. The study revealed that marijuana smokers had significantly higher serum amylase and lipase activities compared to non-smokers. Lipase activity correlated positively (r=0.425, p=0.019) with duration of marijuana use. Amylase activity was higher among males than females (r=-0.40, p=0.028). No significant correlation was found between the quantity of marijuana consumed and enzyme activities. Chronic marijuana consumption was associated with increased serum amylase and lipase activities, indicating potential alterations in pancreatic function. These findings suggest that marijuana use may have adverse effects on digestive health, warranting further investigation into the long-term implications. It is recommended that healthcare providers monitor digestive enzyme activities in marijuana users to detect early signs of pancreatic dysfunction.

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