Detecting Biogenic Amines in Food and Drug Plants with HPLC: Medical and Nutritional Implications
DOI:
https://doi.org/10.29169/1927-5951.2020.10.03.2Keywords:
Neurochemicals, biogenic amines, serotonin, dopamine, norepinephrine, epinephrine, drug plants, food plants, tropical medicine, HPLC.Abstract
Background: This work reports the results of the initial stage of the project aimed at detecting neuroactive substances in tropical plants that are widely used as food and/or drugs.
Methods: The content of neuroactive biogenic amines, e.g, dopamine (DA), norepinephrine (NE), epinephrine (E), serotonin (5-HT), and others was determined using high-performance liquid chromatography (HPLC) with amperometric detection in leaf samples from Plumeria rubra L. cv. acutifolia, Syzigium jambos (L.) Alston, Buxus megistophylla (or Euonymus japonicas cv. aureoma), and Cinnamomum bodinieri Levl.
Results: The total fraction of disintegrated leaves contained (sub)micromolar concentrations of DA, NE, and 5-HT. They lacked E and the catecholamine precursor 2,3-dihydrophenylalanine (DOPA).
Conclusions: From the data obtained, it is evident that heretofore unexplored tropical plants used in drug preparations (P. rubra and S. jambos) and as desserts (S. jambos) and spices (C. bodinieri) contain physiologically active concentrations of neurochemicals. The neurochemicals are expected to produce a significant effect on the people who consume preparations and food additives made from the aforementioned plants. Moreover, such plant preparations can potentially be used as psychoactive drugs for the purpose of intentionally manipulating human behavior.
References
Dubynin VA, Kamensky AA, Sapin MP, Sivoglazov VN. Regulatory systems of the human organism. Moscow: Drofa 2010.
Roshchina VV. Biomediators in plants. acetylcholine and biogenic amines. Pushchino: NTS 1991.
Roshchina VV. Neurotransmitters: plant biomediators and regulators. Pushchino-na-Oke: Institute of Cell Biophysics, Russian Academy of Sciences 2010.
Roshchina VV. Evolutionary considerations of neurotransmitters in microbial, plant, and animal cells. In: Lyte M, Freestone PPE, Eds. Microbial endocrinology: interkingdom signaling in infectious disease and health. New York: Springer 2010; pp. 17-52.
Roshchina VV. New trends in perspectives in the evolution of neurotransmitters in microbial, plant, and animal cells. In: Lyte M, Ed. Microbial endocrinology: interkingdom signaling in infectious disease and health. advances in experimental biology and medicine 874. New York: Springer International Publishing AG 2016; pp. 25-72.
Oleskin AV, Shenderov BA, Rogovsky VS. Role of neurochemicals in the interaction between the microbiota and the immune and the nervous system of the host organism. Probiotics Antimicrob Proteins 2017; 9(3): 215-34. http://doi.org/10.1007/s12602-017-9262-1
Oleskin AV, Shenderov BA. Production of neurochemicals by microorganisms: implications for microbiota–plants interactivity. In: Ramakrishna A, Roshchina VV, Eds. Neurotransmitters in plants: perspectives and applications. Boca Raton, Florida: CRC Press 2018; pp. 271-80.
Lyte M. Microbial endocrinology and the microbiota–gut–brain axis. In: Lyte M, Cryan JF, Eds. Microbial endocrinology: the microbiota–gut–brain axis in health and disease. advances in experimental medicine and biology. 817. New York: Springer 2015; pp. 8-24. http://doi.org/10.1007/978-1-4939-0897-4_1
Roschina VV. Plant neurotransmitters make plants irritable [cited 2020 Feb 20
Subhadrabandhu S. Under-utilized tropical fruits of Thailand. RAP Publication 2001/26. Bangkok: F. A. O. 2001.
World Agroforestry Centre. Available from: http://www.worldagroforestry.org. (accessed April 18, 2020).
Ravindran PN, Babu KN, Shylaja M. Cinnamon and cassia: the genus Cinnamomum. Boca Raton, Florida: CRC Press 2003.
Oleskin AV, Zhilenkova OG, Shenderov BA, Amerhanova AM, Kudrin V S, Klodt PM. Lactic-acid bacteria supplement fermented dairy products with human behavior-modifying neuroactive compounds. J Pharm Nutr Sci 2014; 4P: 199-206. https://doi.org/10.6000/1927-5951.2014.04.03.5
McPherson RA, Pincus MR Henry’s clinical diagnosis and management by laboratory methods. Philadelphia: Elsevier Saunders 2011.
Eldrup E. Significance and origin of DOPA, DOPAC and dopamine-sulfate in plasma, tissue and cerebrospinal fluid. Dan Med Bull 2004; 31: 34-62.
Lyte M. Microbial endocrimology in the pathogenesis of infectious disease. Microbial Spec 2016; 4(2). [cited 2020 Apr 17
Oleskin AV, El’-Registan GI, Shenderov BA. Role of neuromediators in the functioning of the human microbiota: “business talks” among microorganisms and the microbiota-host dialogue. Microbiology 2016; 85(1): 1-22. https://doi.org/10.1134/S0026261716010082
Knecht LD, O’Connor GO, Mittal R, Liu XZ, Daftarian P, Deo SK, Daunert S. Serotonin activates bacterial quorum sensing and enhances the virulence of Pseudomonas aeruginosa in the host. EBioMedicine 2016; 9: 161-9. https://doi.org/10.1016/j.ebiom.2016.05.037
Oleskin AV, Shenderov BA. Microbial communication and microbiota-host interactions: biomedical, biotechnological, and biopolitical implications. New York: Nova Science Publishers 2020.
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Copyright (c) 2020 Cao Boyang , Alexander V. Oleskin , Tatiana Vlasova
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