Accuracy Assessment of Classical Isothermal Experiment in Drug Storage Period Studies
DOI:
https://doi.org/10.6000/1927-5951.2014.04.02.3Keywords:
Classical isothermal experiment, accuracy, ascorbic acid, dissolved oxygen, storage period.Abstract
The purpose of this research was to assessment the effect of change of dissolved oxygen concentration on accuracy of classical isothermal experiment in ascorbic acid solution storage period studies. The experiments were performed at temperatures 35 ˚C, 40 ˚C, 45 ˚C and 50 ˚C, the apparent rate constant (kA) and the adjusted apparent rate constant (kA,A) were determined, respectively. By plotting lnkA and lnkA,A against 1/T resulted two lines, respectively. Then the apparent rate constant at 25 ˚C, kA,25˚C =5.168×10-4(mol×L-1×h-1) and the adjusted apparent rate constant at 25 ˚C, kA,A,25˚C=5.157×10-4(mol×L-1×h-1), was extrapolated, respectively. Both the calculated storage period of the experimented ascorbic acid solution were all 55h by kA,25˚C and kA,A,25˚C， respectively. The results suggested that the change of dissolved oxygen concentration has no effect on the accuracy of classical isothermal experiment in ascorbic acid solution storage period studies.
References
Cui FD. Pharmaceutics. 7th ed. Beijing: People's Medical Publishing House 2011; p. 66.
Feng J, Zhan X, Qiao S, et al. A mathematical model for calculating the shelf life of ascorbic acid solution under given conditions[J
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Shao ML. Pharmacopoeia of the people's Republic of China: Part II. Beijing: Chinese medicine science and Technology Press 2010; p. 904.
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Copyright (c) 2014 Jiafu Feng, Zhigui Zhang , Dixiao Yang
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