Impact Evaluation of Calcium and Vitamin D Supplementation and Physical Activity on Bone Health Status of Elderly Population of Urban Vadodara
DOI:
https://doi.org/10.6000/1927-5951.2015.05.01.8Keywords:
Elderly, BMD, Calcium, Vitamin D, Physical Activity.Abstract
Background: Osteoporosis is a global public health problem affecting the ageing population and influenced by poor nutrition, lack of physical activities, and absence of supplementation on time.
Objectives: To study the impact of Calcium and vitamin D supplementation along with weight bearing exercises on bone health status of elderly.
Methods:30 elderly males and 20 elderly females having poor BMD and poor serum vitamin D were supplemented with 1000 mg calcium and 500 IU vitamin D/ day along with weight bearing exercises for a period of 3 months, along with that 60000 IU vitamin D3/week for 2 months were given to 30 males only. Serum calcium, Vitamin D, BMD, dietary calcium intake, frequency of vitamin D rich food intake, anthropometry etc. were measured at the baseline as well as after the intervention.
Results: Mean BMD T-scores (-1.1 to -2.5: osteopenia; >-2.5: osteoporosis) of the elderly males and females were significantly (p?0.001) decreased after the intervention depicting improvement (baseline:-2.34±0.50, final:-1.86±0.61). 26.7% reduction in osteoporotic cases among males and 50 % among women was achieved. Mean serum calcium (baseline: 9.38±0.63, final: 9.46±0.61) and vitamin D level (baseline: 23.76±13.17, final: 35.48±14.84) was increased significantly (p?0.05). 60% males and 70% females achieved vitamin D sufficiency level after the intervention. Mean physical endurance (Grip strength, standing balance, walking speed and rise from chair) scores were significantly increased in both males and females. Locomotor problems were reduced among 6.7% males and 40% females after regular weight bearing exercise and supplementation.
Conclusion:Calcium and vitamin D supplementation with daily weight bearing exercise has a preventive and curative effect on BMD and it maintains the serum calcium and vitamin D levels. Long term and high dose supplementation needs further investigation.
References
Cummings S, Melton L. Epidemeology and outcomes of osteoporotic fracture. Lancet 2002; 359: 1761-1767. http://dx.doi.org/10.1016/S0140-6736(02)08657-9
Szulc P, Munoz F, Duboeuf F, et al. Bone mineral density predicts osteoporotic fractures in elderly men: the MINOS study. Osteoporosis International 2005; 16: 1184. http://dx.doi.org/10.1007/s00198-005-1970-9
Samar DM, Kribakaran V, Savita R, Anburajan M. Screening Rural and Urban Indian Population for osteoporosis using heel ultrasound Beone Denditometer. International Conference on Communication Systems and Network Technologies 2011; 629-633.
Osteoporosis Society of India. Consensus statement of an expert group. New Delhi 2003.
Rizvi H, Vaishnava S. Frequency of osteomalacia and osteoporosis in fractures of proximal femur 1974; 1: 676-7.
Cashman K, Flynn A. Trace elements and bone metabolism. Bibliotheca Nutrition Et Dieta 1998; 54: 150-164.
Land Coup C, Wood D, Cooper C. Physical inactivity is an independent risk factor for hip fracture in the elderly. Journal of Epidemiology and Community Health 1993; 47(6): 441-443. http://dx.doi.org/10.1136/jech.47.6.441
Gupta A. Osteoporosis in India the nutritional hypothesis. National Medcal Journal of India 1996; 9: 268-74.
Murray CJL, Lopez AD. The global burden of diseases, injuries, and risk factors in 1990 and projected to 2020. Cambridge: Harvard University Press 1996.
Dawson HB, Harris SS, Karl EA, Dallal GE. Effect of calcium and vitamin D supplimentation on bone density in men and women 65 yeras of age or older. The New England Journal of Medicine 1997; 337(10): 670-676. http://dx.doi.org/10.1056/NEJM199709043371003
Marwaha RK, Tandon N, Garg MK, Kanwar R, Narang A, Sastry A, Saberwal A, Bandra K. Vitamin D status in healthy Indians aged 50 years and above. Journal of Association Physician, India 2011; 56: 706-9.
Berger C, Greene-Finestone LS, Langsetmo L, Kreiger N, Joseph L, Kovacs CS, Richards JB, Hidiroglou N, Sarafin K, Davison KS, Adachi JD, Brown J, Hanley DA, Prior JC, Goltzman D, the CaMos Research Group, Temporal Trends and Determinants of Longitudinal Change in 25 Hydroxyvitamin D and Parathyroid Hormone Levels. JBMR 2012; 27(6): 1381-1389. http://dx.doi.org/10.1002/jbmr.1587
WHO, Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Technical report series 843, Geneva 1994.
Hollick MF. Vitamin D Deficiency. N Engl J Med 2007; 357: 266-81. http://dx.doi.org/10.1056/NEJMra070553
Satyanarayana U, Chakrapani U. Biochemistry, Books and Allied (P) Ltd. 2010; pp. 406-407
Seshadiri S. A data base in IDA in India, prevalence, etiology, Consequences and strategies for control, prepared for Ministry of Human Resource Development, New Delhi, 1999.
Bass S. Exercise before puberty may confer residualbenefits in Bone density in adulthood: studies in active prepubertal and retired female gymnasts. Journal of Bone Mineral Research 1998; 13: 500-507. http://dx.doi.org/10.1359/jbmr.1998.13.3.500
Moayyeri A. The Association Between Physical Activity and Osteoporotic Fractures: A Review of the Evidence and Implications for Future Research. Annals of Epidemiology 2008; 18(11): 827-835. http://dx.doi.org/10.1016/j.annepidem.2008.08.007
Hughes-Dawson B, Harris SS, Karl EA, Dallal GE. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age and older. England Journal of Medicine 1997; 337: 670-676. http://dx.doi.org/10.1056/NEJM199709043371003
Mackerras D, lumley T. First and second year effects in traisl of calcium supplementation on the loss of bone density in post menopausal women. Bone Mineral Journal 1997; 527-33.
Cashman KD. Calcium intake, calcium bioavailibity and bone health. Edited by The Author 2002. British Journal of Nutrition 2002; 82(Suppl. 2).
Chaupuy MD, Arlot ME, Delmas PD, Meuneir PJ. Effect of Calcium and cholecalciferol treatment for three years on hip fractures in elderly women. British Medical Journal 1994; 1081-82. http://dx.doi.org/10.1136/bmj.308.6936.1081
Shea B, Wells G, Cranney A, et al. Meta-analyses of therapies for postmenopausal osteoporosis. VII. Meta-analysis of calcium supplementation for the prevention of postmenopausal osteoporosis. Endocrinology Review 2002; 23: 552. http://dx.doi.org/10.1210/er.2001-7002
Malhotra N, Mithal A, Gupta S, Shukla M, Godbole M. Effect of vitamin D supplementation on bone health parameters of healthy young Indian women. Archives of Osteoporosis 2009; 4: 47-53. http://dx.doi.org/10.1007/s11657-009-0026-8
Goswami R, Gupta N, Ray D, Singh N, Tomar N. Pattern of 25-hydroxy vitamin D response at short (2 months) and long (1 year) interval after 8 weeks of oral supplementation with cholecalciferol in Asian Indians with chronic hypovitaminosis D. British Journal of Nutrition 2008; 100: 526-9. http://dx.doi.org/10.1017/S0007114508921711
Kuttikat A, Grant R, Chakravarty K, Management of Osteoporosis. Journal of Indian Rheumatology Association 2004; 12.
Nguyen TV, Eisman JA. Risk factors for low bone mass in elderly men. In: ES Orwoll (ed) Osteoporosis in Men. Academic Press, San Diego, 1999; p. 335. http://dx.doi.org/10.1016/B978-012528640-4/50018-6
Iqbal SP, Dodani S, Qureshi R. Risk factors and behaviours for coronary artery disease (CAD) among ambulatory Pakistanis. Journal of Pakistan Medical Association 2004; 54: 261-6.
Fatima M, Nawaz H, Kassi M, Rehman R, Kasi PM, Kassi M, Afghan AK, Baloch SN. Determining the risk factors and prevalence of osteoporosis using quantitative ultrasonography in Pakistani adult women. Singapore Medical Journal 2009; 50(1): 20.
Nutrient requirements and recommended dietary allowances for Indians, ICMR task force report, NIN 2009.
Downloads
Published
Issue
Section
License
Copyright (c) 2015 Annapurna Maity, Komal Chauhan, Nishita Panwar , Pooja Mistry

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
Similar Articles
- Partha Protim Nath, Md. Shafiul Hossen, Sonia Akther Papia, Samina Yesmin Trisha, Irin Sultana, Mohammed Ibrahim, Phytochemical and Biological Investigations of Different Partitioned Extracts of Ficus heteropleura Blume (Family: Moraceae) Leaves , Journal of Pharmacy and Nutrition Sciences : Vol. 14 (2024)
- Saghir Ahmed Sheikh, Benish Nawaz Merani, Aijaz Hussain Somro, Liaquat Jamali , Aasia Akbar Panhwar, Investigation of Physical Quality Characteristics of Dry Land and Wet Land Wheat Varieties , Journal of Pharmacy and Nutrition Sciences : Vol. 4 No. 2 (2014)
- Md. Al Amin Sikder, Abu Bakar Siddique, A.K.M. Nawshad Hossian, Md. Kowser Miah, Mohammad A. Kaisar, Mohammad A. Rashid, Evaluation of Thrombolytic Activity of Four Bangladeshi Medicinal Plants, as a Possible Renewable Source for Thrombolytic Compounds , Journal of Pharmacy and Nutrition Sciences : Vol. 1 No. 1 (2011)
- Fokhrul Abedin , Md. Saddam Hussain , Areful Islam , Niloy Sen , Abhijit Das , Auditi Kar , Md. Monir Hossain , Md. Shalahuddin Millat , Mohammad Safiqul Islam, Thrombolytic, CNS Depressant and Anti-Diarrhoeal Activities of Ethanolic Extract of Bark of Syzygium cumini L. Skeels: An In-Vivo and In-Vitro Study , Journal of Pharmacy and Nutrition Sciences : Vol. 8 No. 3 (2018)
- José Antonio Garzón Tiznado, Mar de Jesús Heiras Palazuelos, Ramona Julieta Espinoza Moreno, Mirta Cano Campos, Francisco Delgado Vargas, Roberto Gutiérrez Dorado, Jorge Milán Carrillo, Cuauhtémoc Reyes Moreno, Antioxidant and Antimutagenic Activities of Optimized Extruded Desi Chickpea (Cicer arietinum L) Flours , Journal of Pharmacy and Nutrition Sciences : Vol. 3 No. 1 (2013)
- Anthonia Ogheneruno Ugboduma, Francis Adu, Christian Agyare, Kofi Annan , Samuel Osei-Asante, Phytochemical Screening and Antimicrobial Activity of Entandrophragma angolense , Journal of Pharmacy and Nutrition Sciences : Vol. 3 No. 4 (2013)
- Thanawat Pattananandecha, Jakkapan Sirithunyalug, Busaban Sirithunyalug, Kannika Thiankhanithikun, Chartchai Khanongnuch, Chalermpong Saenjum, Bioactive Compounds Constituent and Anti-Inflammatory Activity of Natural Rice Bran Oil Produced from Colored and Non-Pigmented Rice in Northern Thailand , Journal of Pharmacy and Nutrition Sciences : Vol. 9 No. 4 (2019)
- Stefania Garzoli, Secondary Metabolites: Detection and Bioactivity , Journal of Pharmacy and Nutrition Sciences : Vol. 12 (2022)
- Ajeet, Laxmi Tripathi , Arvind Kumar, Synthesis, Spectral Characterization, Docking Studies and QSAR Screening of 4-amino-benzenesulfonamides/N-acetyl 4-amino-benzenesulfonamide Derivatives as Antimicrobial Agents , Journal of Pharmacy and Nutrition Sciences : Vol. 4 No. 2 (2014)
- Shabana Saeed , Samina Bano, Improved Serotonergic Tone Contributes to the Mechanism of Action of St John’s Wort in Nicotine Withdrawn Mice , Journal of Pharmacy and Nutrition Sciences : Vol. 4 No. 4 (2014)
You may also start an advanced similarity search for this article.