logo

In Vitro Dissolution Interference Study in Presence of Paracetamol Tablets with Freshly Prepared Mango Juices on Simulated Gastrointestinal Digestion

Authors

  • Md. Didaruzzaman Sohel

    State University of Bangladesh, Dhaka-1205, Bangladesh

  • Faisal Asif

    State University of Bangladesh, Dhaka-1205, Bangladesh

  • Md. Helal Uddin Sumon

    NIPRO JMI Pharma Ltd. Rajendrapur, Chauddagram, Comilla, Bangladesh

  • Kaniz Fatema  

    State University of Bangladesh, Dhaka-1205, Bangladesh

  • Md. Hassan Kawsar

    State University of Bangladesh, Dhaka-1205, Bangladesh

DOI:

https://doi.org/10.29169/1927-5951.2020.10.04.4

Keywords:

Paracetamol, Drug Interactions, Mango Juice, Bangladesh.

Abstract

This study is performed beneath In Vitro dissolution applying various mathematical approaches to observe the dissolution interference on simulated gastrointestinal digestion. In total, eight medicine samples wereollected in Bangladeshi market and the conventional approaches were followed to measure the result in gastric medium (pH 1.2). Altogether, the brands showed sensibly upper dissolution discharge; primarily P01 (98.9%), P08 (98.97%), P03 (98.32%) and P06 (98.24%) were released relatively faster than the other sample in 15 to 60 minutes. Along with the mango juice in the simulated gastric medium, the brands showed sensibly upper dissolution discharge; primarily P01 (98.83%), P07 (98.98%), P06 (98.78%) and P03 (98.38%) were released relatively faster than the other sample in 15 to 60 minutes. This result depicts to understand the proper release of kinetics with the help of various mathematical model such as Zero order, First order, Higuchi and Hixson-Crowell model etc. although Paracetamol can interact with the fruit juices, which may alter the drug release, drug absorption in the body and may also lead to an unwanted reaction.

References

Leyk E, Wesolowski M. Interactions between Paracetamol and Hypromellose in the Solid State. Front Pharmacol 2019; 10: 14. https://doi.org/10.3389/fphar.2019.00014

Bennett PN, Brown MJ. Clinical Pharmacology, 10th Edn. Edinburgh: Churchill Livingstone; Elsevier 2008.

Pem D, Jeewon R. Fruit and Vegetable Intake: Benefits and Progress of Nutrition Education Interventions- Narrative Review Article. Iran J Public Health 2015; 44(10): 1309-21.

Raisha M, Ahmad A, Ahmad and M, Khalid A, et al. Effects of sinapic acid on hepatic cytochrome P450 3A2, 2C11 and intestinal P-glycoprotein on the pharmacokinetics of oral carbamazepine in rats: Potential food/herb-drug interaction. Epilepsy Research 2019; 153: 14-18. https://doi.org/10.1016/j.eplepsyres.2019.03.012

Rahman MM, Islam S, Islam MA, and Alam MS et al. Varietal Performance of Turmeric under Mango Based Agroforestry System. American Journal of Plant Sciences 2018; 9(5): 995-1003. https://doi.org/10.4236/ajps.2018.95076

Baxter K, Sharp J, Marshall A, Driver S. Drug interactions and fruit juices. The Pharmaceutical Journal, 2008; p. 333.

Showande SJ, Fakeye TO, Kajula M, and Hokkanen J et al. Potential inhibition of major human cytochrome P450 isoenzymes by selected tropical medicinal herbs—Implication for herb–drug interactions, Food Sci Nutr 2019; 7: 44-55. https://doi.org/10.1002/fsn3.789

Rodri?guez-Fragoso L and Reyes-Esparza J. Fruit/Vegetable-Drug Interactions: Effects on Drug Metabolizing Enzymes and Drug Transporters, Drug Discovery. Hany A. El-Shemy, 23rd 2013; Intech Open. https://doi.org/10.5772/48283

Mazaleuskaya LL, Sangkuhl K, Thorn CF, and FitzGerald GA, et al. Pathways of acetaminophen metabolism at the therapeutic versus toxic doses, Pharmacogenet Genomics 2015; 25(8): 416-426. https://doi.org/10.1097/FPC.0000000000000150

Asif F, Sultana T, Sohel MD, Sumon MHU, Kawsar MK, Islam MA. In vitro Dissolution Pattern of Metronidazole Film Coated Tablet in Presence of Fruit Juice. American Journal of Pharmacological Sciences 2014; 2(2): 32-36. https://doi.org/10.12691/ajps-2-2-1

British Pharmacopoeia, 2012. p. 57.

Halder S, Shuma ML, Kabir AKL, Rouf ASS. In vitro release kinetics study of Esomeprazole Magnesium Trihydrate tablet available in Bangladesh and comparison with the originator brand (Nexium®). S J Pharm Sci 2011; 4(1): 79-83. https://doi.org/10.3329/sjps.v4i1.8875

Thakkar VT, Shah PA, Soni TG, Parmar MY, Gohel MC, et al. Goodness-of-fit model-dependent approach for release kinetics of levofloxacin hemihydrates floating tablet. Dissolution Technologies 2009; 16: 35-39. https://doi.org/10.14227/DT160109P35

Himadri Sahua and Kaustubha Mohanty et al. Pseudo-first order reaction kinetics and thermodynamic properties study of neem oil esterification using MgO grafted natural hydroxyapatite 2016; 11(6): 2-40. https://doi.org/10.1039/C5RA25095A

Siepman J, Peppas NA. Higuchi equation: Derivation, applications, use and misuse. Int J of ph 2011; 6-12. https://doi.org/10.1016/j.ijpharm.2011.03.051

Singhvi G, Singh M. In vitro drug release characterization models. Int J Pharm Stud Res 2011; 2: 77-84.

Downloads

Published

2020-08-05

Issue

Vol. 10 No. 4 (2020)

Section

Articles

License

Copyright (c) 2020 Md. Didaruzzaman Sohel , Faisal Asif , Md. Helal Uddin Sumon , Kaniz Fatema  , Md. Hassan Kawsar

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

In Vitro Dissolution Interference Study in Presence of Paracetamol Tablets with Freshly Prepared Mango Juices on Simulated Gastrointestinal Digestion. (2020). Journal of Pharmacy and Nutrition Sciences , 10(4), 148-154. https://doi.org/10.29169/1927-5951.2020.10.04.4

Similar Articles

11-20 of 65

You may also start an advanced similarity search for this article.

Most read articles by the same author(s)