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Benthaminin 3, a Novel Antibacterial Cassane-Type Furanoditerpenoid from Caesalpinia benthamiana

Authors

  • Rita A. Dickson

    Kwame Nkrumah University of Science and Technology, Ghana

  • Kofi Annan

    Kwame Nkrumah University of Science and Technology, Ghana

  • Theophilus C. Fleischer

    Kwame Nkrumah University of Science and Technology, Ghana

  • Peter J. Houghton

    King’s College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK

DOI:

https://doi.org/10.6000/1927-5951.2012.02.01.3

Keywords:

 Caesalpinia benthamiana (Baill.) Herend. and Zarucchi, Mezoneuron benthamianum Baill, Caesalpinaceae, Cassane-type furanoditerpenoids, Antibacterial activities.

Abstract

The roots of Caesalpinia benthamiana (synonym. Mezoneuron benthamianum)are considered to be an effective remedy in Ghana for the management of skin diseases and wounds. Bioactivity-guided fractionation of the chloroform extract of the root bark of the plant has resulted in the isolation of a novel cassane-type furanoditerpenoid, designated as benthaminin 3. The structure of the compound was elucidated by the use of spectroscopic techniques. The antibacterial activity of the compound has been assessed using the microdilution assay method. The lowest MIC (63μg/mL) was recorded against Staphylococcus aureus and Bacillus subtilis. The compound wasalso observed to have a mild inhibitory effect against resistant strains of bacteria including methicillin-resistant S. aureus, tetracyline-resistant S. aureus and erythromycin-resistant S. aureus with MIC values greater than 1000μg/mL.

References

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Published

2012-01-05

Issue

Vol. 2 No. 1 (2012)

Section

Articles

License

Copyright (c) 2012 Rita A. Dickson, Kofi Annan, Theophilus C. Fleischer , Peter J. Houghton

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

Benthaminin 3, a Novel Antibacterial Cassane-Type Furanoditerpenoid from Caesalpinia benthamiana . (2012). Journal of Pharmacy and Nutrition Sciences , 2(1), 20-25. https://doi.org/10.6000/1927-5951.2012.02.01.3

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