Prospective Study on the Effects of Marijuana Smoking on Lipase and Amylase Activities among Adult Nigerians
DOI:
https://doi.org/10.29169/1927-5951.2024.14.04Keywords:
Adult, Marijuana Smoking, Prospective Studies, Amylase, Lipase, Humans, PancreatitisAbstract
Marijuana consumption is prevalent among young adults in Nigeria, and its effects on various physiological systems are of growing concern. This study investigates the impact of marijuana use on digestive enzymes, specifically serum amylase and lipase, to understand its potential implications on digestive health. This cross-sectional study was conducted in 120 participants comprising of 60 marijuana smokers and 60 non-smokers. Sociodemographic and lifestyle data were collected through structured questionnaires. Serum amylase and lipase activity levels were measured by spectrophotometric method and compared between the two groups. Statistical analysis was performed to assess differences and correlations. The study revealed that marijuana smokers had significantly higher serum amylase and lipase activities compared to non-smokers. Lipase activity correlated positively (r=0.425, p=0.019) with duration of marijuana use. Amylase activity was higher among males than females (r=-0.40, p=0.028). No significant correlation was found between the quantity of marijuana consumed and enzyme activities. Chronic marijuana consumption was associated with increased serum amylase and lipase activities, indicating potential alterations in pancreatic function. These findings suggest that marijuana use may have adverse effects on digestive health, warranting further investigation into the long-term implications. It is recommended that healthcare providers monitor digestive enzyme activities in marijuana users to detect early signs of pancreatic dysfunction.
References
Song D, Geetha HS, Jain S, Reyes JV, Jaiswal V, Nepal G, Lieber J. Delayed presentation of cannabis induced pancreatitis. Clin Case Rep 2022; 10(3): e05595. https://doi.org/10.1002/ccr3.5595
United Nations Office on Drugs and Crime (UNODC). UN system coordination task team on the implementation of the U.N. system common position on drug-related matters, what we have learned over the last ten years: A summary of knowledge acquired and produced by the U.N. system on drug-related matters 2019. https://www.unodc.org accessed 12/09/2024
World Health Organization. WHO global report on trends in tobacco smoking 2000–2025. Geneva: World Health Organization 2019. https://who.int/newroom/sportlight accessed 14/03/2024
Abdurahman H, Adejumo O, Abdulmalik J. Prevalence of psychoactive substance use among male adolescents in Southwest Nigeria. J Substance Abuse 2019; 24(5): 475-480. https://doi.org/10.1080/14659891.2019.1604840
Adedayo BC, Oyeleye SI, Okeke BM Oboh G. Anti-cholinesterase and antioxidant properties of alkaloid and phenolic-rich extracts from pawpaw (Carica papaya) leaf: A comparative study. Flavour Fragrance J 2020; 36(9): 1-8. https://doi.org/10.1002/ffj.3615
Koumbi L, Giouleme O, Vassilopoulou E. Non-Celiac Gluten Sensitivity and Irritable Bowel Disease: Looking for the Culprits. Curr Dev Nutr 2020; 4(12): nzaa176. https://doi.org/10.1093/cdn/nzaa176
Lwanga SK, Lemeshow S, World Health Organization. Sample size determination in health studies : a practical manual / S. K. Lwanga and S. Lemeshow. World Health Organization 1991; https://iris.who.int/handle/10665/40062
World Health Organization. Cannabis in Alcohol, Drugs and Addictive Behaviours. https://www.who.int/teams/mental-health-and-substance-use/alcohol-drugs-and-addictive-behaviours/drugs-psychoactive/cannabis# Accessed 07/09/2024
Jeffers AM, Glantz S, Byers A, Keyhani S. Sociodemographic Characteristics Associated With and Prevalence and Frequency of Cannabis Use Among Adults in the US. JAMA Netw Open 2021; 4(11): e2136571. https://doi.org/10.1001/jamanetworkopen.2021.36571
Hall W, Degenhardt L. Adverse health effects of non-medical cannabis use. Lancet 2009; 374(9698): 1383-91. https://doi.org/10.1016/S0140-6736(09)61037-0
Volkow ND, Baler RD, Compton WM, Weiss SR. Adverse health effects of marijuana use. N Engl J Med 2014; 370(23): 2219-27. https://doi.org/10.1056/NEJMra1402309
Pacher P, Bátkai S, Kunos G. The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev 2006; 58(3): 389-462. https://doi.org/10.1124/pr.58.3.2
Di Marzo V, Bifulco M, De Petrocellis L. The endocannabinoid system and its therapeutic exploitation. Nat Rev Drug Discov 2004; 3(9): 771-84. https://doi.org/10.1038/nrd1495
Klein TW. Cannabinoid-based drugs as anti-inflammatory therapeutics. Nat Rev Immunol 2005; 5(5): 400-11. https://doi.org/10.1038/nri1602
Rompianesi G, Hann A, Komolafe O, Pereira SP, Davidson BR, Gurusamy KS. Serum amylase and lipase and urinary trypsinogen and amylase for diagnosis of acute pancreatitis. Cochrane Database Syst Rev 2017; 4(4): CD012010. https://doi.org/10.1002/14651858.CD012010.pub2
Patel P, Lo SF, Tashkin DP. Marijuana and the lung: Paradoxical effects. Brit J Pharmacol 2005; 144(8): 1037-1047. https://doi.org/10.1002/j.1552-4604.2002.tb06006.x
Tashkin DP, Baldwin GC, Sarafian T, Dubinett S, Roth MD. Respiratory and immunologic consequences of marijuana smoking. J Clin Pharmacol 2002; 42(S1): 71S-81S.
Sharma R. Amylase and Lipase Test: Understanding and Exploring the significance of Enzyme Levels, Ganesh Diagnostic and Imaging Centre Pvt. Ltd, Rohini, New Delhi 110085 2023. www.ganeshdiagnostic.com accessed 10/09/2024
Lubega F, Lwanga A. An Unexpected Case of Cannabis-Induced Pancreatitis. Cureus 2021; 13(2): e13253. https://doi.org/10.7759/cureus.13253
Wargo KA, Geveden BN, McConnell VJ. Cannabinoid-induced pancreatitis: a case series. JOP 2007; 8(5): 579-583.
Goyal H, Guerreso K, Smith B, Harper K, Patel S, Patel A, Parikh P. Severity and outcomes of acute alcoholic pancreatitis in cannabis users. Transl Gastroenterol Hepatol 2017; 2: 60. https://doi.org/10.21037/tgh.2017.06.03
Pagliari D, Saviano A, Brizi MG, Mancarella FA, Cannone F, Musso M et al. Cannabis-induced acute pancreatitis: a case report with comprehensive literature. Eur Rev Med Pharmacol Sci 2019; 23: 8625-8629.
Wang GJ, Gao CF, Wei D, Wang C, Ding SQ. Acute pancreatitis: etiology and common pathogenesis. World J Gastroenterol 2009; 15(12): 1427-30. https://doi.org/10.3748/wjg.15.1427
Grant P, Gandhi P. A case of cannabis-induced pancreatitis. JOP 2004; 5: 41-43.
Antoniou T, Bodkin J, Ho JM. Drug interactions with cannabinoids. CMAJ 2020; 192(9): E206. https://doi.org/10.1503/cmaj.191097
Murphy T, Matheson J, Mann RE, Brands B, Wickens CM, Tiwari AK, Zai CC, Kennedy J, Le Foll B. Influence of Cannabinoid Receptor 1 Genetic Variants on the Subjective Effects of Smoked Cannabis. Int J Mol Sci 2021; 22(14): 7388. https://doi.org/10.3390/ijms22147388
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
Similar Articles
- Suyanee Pongthananikorn, Jitprasong Lamsaard , Tippawan Siritientong, Effectiveness of Web-Based Nutrition Education for Chronic Kidney Disease Patients , Journal of Pharmacy and Nutrition Sciences : Vol. 8 No. 4 (2018)
- Andi Imam Arundhana , Muhammad Syafruddin Nurdin , Veni Hadju , Ansariadi , Andi Zulkifli, The Effect of Moringa-Based Supplementation on Fetal Birth Weight in Jeneponto Regency , Journal of Pharmacy and Nutrition Sciences : Vol. 8 No. 3 (2018)
- Safaa A. Al-Zeidaneen , Mousa A. Ahmad , Ali D. Al-Ebuos, Impact of Chemotherapy Treatments on Dietary Intakes of Macro and Micronutrients among Jordanian Women with Breast Cancer , Journal of Pharmacy and Nutrition Sciences : Vol. 8 No. 3 (2018)
- Eman Aly Sadeek Fadlalla, Cardio-Nephroprotective Effects of Guava and Olive Leaves Extracts on Doxorubicin-Induced Toxicity in Rats , Journal of Pharmacy and Nutrition Sciences : Vol. 8 No. 3 (2018)
- Robinson, B. Lu, I. Edirisinghe , C.T. Kappagoda, Effect of Grape Seed Extract on Blood Pressure in Subjects with Pre-Hypertension , Journal of Pharmacy and Nutrition Sciences : Vol. 2 No. 2 (2012)
- Ziming, Dianpeng Li, Haiying Jiang, Guiyun Qian, Weiguo Sui, Guimian Zou, Hourui Zhang, The Effects of Consumption L-Arabinose on Metabolic Syndrome in Humans , Journal of Pharmacy and Nutrition Sciences : Vol. 3 No. 2 (2013)
- Alexander A. Kravtsov , Stanislav V. Kozin , Ekaterina R. Vasilevskaya , Anna A. Elkina , Lilia V. Fedulova , Konstantin A. Popov , Vadim V. Malyshko , Arkady V. Moiseev , Denis I. Shashkov , Mikhail G. Baryshev, Effect of Drinking Ration with Reduced Deuterium Content on Brain Tissue Prooxidant-Antioxidant Balance in Rats with Acute Hypoxia Model , Journal of Pharmacy and Nutrition Sciences : Vol. 8 No. 2 (2018)
- Evanie D. Deenanath, Abdulkadir Egal, Food Extrusion Technology: Initiatives to Address Food and Nutrition Insecurity in South Africa , Journal of Pharmacy and Nutrition Sciences : Vol. 7 No. 3 (2017)
- Naeem Quraishi, Tasneem Ahmad, Allah-Bux Ghanghro, Abdullah Arejo, Sharib S. Muhammad, Atta Chandio, Phase II Clinical Trial to Establish Efficacy of a Locally Appropriate Bivalent Anti Snake Venom in Pakistan , Journal of Pharmacy and Nutrition Sciences : Vol. 7 No. 3 (2017)
- Miles Chih-Ming Chena, Pei-Ni Chena, Howard Hao-Yu Chenga, Wayne Ching-Cheng Weia, Ryuji Takedab, Mitsuko Moric , Kiichiro Mochidad, Effects of Antrodia Camphorata Mycelia Extract Containing Antroquinonol on Lowering Low-Density Lipoprotein Cholesterol: A Randomized Double-Blind Study , Journal of Pharmacy and Nutrition Sciences : Vol. 7 No. 3 (2017)
You may also start an advanced similarity search for this article.