Evaluating the Protective Effects of a Pet Supplement Containing Calcium Carbonate, Magnesium Hydroxide and Natural Ingredients (Gastrik Pet®, Candioli S.r.l.) on Gastric Cells and Cytotoxicity Reduction under Hyperacidity Conditions: An In Vitro Study

N. Lonigro; E. Martello; F. Perondi; A. Melocchi; A. Testa; N. Bruni

doi:10.29169/1927-5951.2025.15.02

Evaluating the Protective Effects of a Pet Supplement Containing Calcium Carbonate, Magnesium Hydroxide and Natural Ingredients (Gastrik Pet®, Candioli S.r.l.) on Gastric Cells and Cytotoxicity Reduction under Hyperacidity Conditions: An In Vitro Study

Authors

N. Lonigro Department of Drug Science and Technology, University of Turin, Turin, Italy
E. Martello Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, UK
F. Perondi Department of Veterinary Science, University of Pisa, San Piero a Grado (Pisa), Italy
A. Melocchi PhormulaMI Lab, Department of Pharmaceutical Sciences, University of Milan, Italy
A. Testa Candioli Pharma S.r.l., Beinasco (TO), Italy
N. Bruni Candioli Pharma S.r.l., Beinasco (TO), Italy

DOI:

https://doi.org/10.29169/1927-5951.2025.15.02

Keywords:

Pet, Acidity, Gastritis, Stomach, Natural products

Abstract

Effective acid suppression is crucial for treating gastritis in pets. This in vitro study aimed to evaluate and compare the protective effects of two products on gastric cells under conditions of high acidity: 1) a supplement (Gastrik Pet®, Candioli srl) containing selected natural ingredients including Promugel®(a complex of mucilage protecting the mucosa from gastric acidity: Guar meal, Psyllium (Plantago Ovata L.), Trigonella foenum-graecum L.) and antacid salts (calcium carbonate and magnesium hydroxide) and 2) sucralfate, a treatment used in human and veterinary medicine. Gastrik Pet® showed superior efficacy in protecting gastric cells from acid-induced cytotoxicity at all concentrations tested compared to sucralfate. These results suggest that this natural pet supplement could be a promising option for managing gastritis-related conditions in pets. Further research, including in vivo studies, is needed to confirm these findings and assess its clinical potential.

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