Phenolic Compounds and Antioxidant Activities of Skins and Seeds of Foreign and Iranian Grapes
DOI:
https://doi.org/10.6000/1927-5951.2014.04.01.9Keywords:
Vitis, Grape skin, Grape seed, Phenol, Antiradical activity.Abstract
Grape skins and seeds are sources of phenolic compounds that contribute to the sensory characteristics and beneficial bioactivity of wines and other processed foods. Grape seed and skin extracts from foreign, wild and Iranian cultivars were assayed for their antioxidant properties and phenolic compositions. Finally, the results were compared with those of Vitis vinifera cv. Muscat of Alexandria and V.labrusca. Among the skins of grape cultivars analyzed, those of Lalsiyah contained the highest amount of total phenolics (1067.5 mg 100g-1 gallic acid equivalent of fresh weight) and antiradical activities (0.79 m mol g-1 trolox equivalent of fresh weight). In contrast, Dedeskiramfi contained highest amount of seed total phenolics (2277.3 mg 100 g-1 GAE of fresh weight). The phenolic content of different grapes depends mainly on the grape skin color. The total phenolic content of W8 and W11 with white skins was significantly different from grapes with dark skins. Lalsiyah skin contained the highest amount of total flavonoid, total anthocyanins content, total procyanidin monomers and antiradical activity. Since, total phenolic content is an index of potent antioxidant capability; Lalsiyah will be good resource of antioxidant in food and pharmaceutical industries.
References
Wen J. The Families and Genera of Vascular Plants. In: Kubitzki, K. (Ed.), Vitaceae, Berlin, Germany: Springer-Verlag 2007; 9: 466-478.
Wen J, Nie ZL, Soejima A, Meng Y. Phylogeny of Vitaceae based on the nuclear GAI1 gene sequences. Can J Bot 2007; 85: 731-45. http://dx.doi.org/10.1139/B07-071
Corder R, Mullen W, Khan NQ, Marks SC, Wood EG, Carrier MJ, Crozier A. Oenology: red wine procyanidins and vascular health. Nature 2006; 444-566.
Lea AGH, Bridle P, Timberlake CF, Singleton VL. The procyanidins of white grapes and wines. Am J Enol Viticult 1979; 30: 289-300.
Bozan B, Tosun G, Ozcan D. Study of polyphenol content in the seeds of red grape (Vitis vinifera L.) varieties cultivated in Turkey and their antiradical activity. J Food Chem 2008; 109(2): 426-30. http://dx.doi.org/10.1016/j.foodchem.2007.12.056
Li HB, Xia EQ, Deng GF, Guo YJ.Biological activities of polyphenols from grapes. Int J Mol Sci 2010; 11(2): 622-46. http://dx.doi.org/10.3390/ijms11020622
Semberies S, Dongowski G, Mehrlander K, Will F, Dietrich H. Physiological effects of extraction juices from apple, grape, and red beet pomaces in rats. J Agric Food Chem 2006; 54(26): 10269-280. http://dx.doi.org/10.1021/jf0618168
Frankel EN. Potential health benefits of grape and wine antioxidants. Medically, is wine just another alcoholic beverage. In C. S. Stockley (Ed.). Proceedings of the wolf Blass foundation international wine and health conference 1996; 45-49.
Hertog MGL, Hollman PCH, Van De Putte B. Content of potentially anticarcinogenic flavonoids of tea infusions, wines and fruit juices. J Agricul Food Chem 1993; 41: 1242-46. http://dx.doi.org/10.1021/jf00032a015
Merken HM, Beecher GR. Liquid Chromatographic method for the separation and quantification of prominent flavonoid aglycones. J Chromatogr A 2000; 897: 177-84. http://dx.doi.org/10.1016/S0021-9673(00)00826-8
Sato M, Bagchi D, Tosaki A, Das DK. Grape seed proanthocyanidin reduces cardiomyocyte apoptosis by inhibiting ischemia/reperfusion-induced activation of JNK-1 and C-JUN. Free Radical Biol Med 2001; 31(6): 729-37. http://dx.doi.org/10.1016/S0891-5849(01)00626-8
Cooke D, Steward WP, Gescher AJ, Marczylo T. Anthocyans from fruits and vegetables - Does bright colour signal cancer chemopreventive activity? Eur J Cancer 2005; 41(13): 1931-40. http://dx.doi.org/10.1016/j.ejca.2005.06.009
Hou DX. Potential mechanisms of cancer chemoprevention by anthocyanins. Curr Mol Med 2003; 3(2): 149-59. http://dx.doi.org/10.2174/1566524033361555
Kamiyama M, Kishimoto Y, Tani M, Andoh K, Utsunomiya K, Kondo K. Inhibition of low-density lipoprotein oxidation by nagano purple grape (Vitis vinifera x Vitis labrusca). J Nutr Sci Vitaminol 2009; 55(6): 471-78. http://dx.doi.org/10.3177/jnsv.55.471
Prior RL, Wu XL. Anthocyanins: Structural characteristics that result in unique metabolic patterns and biological activities. Free Radical Res 2006; 40(10): 1014-28. http://dx.doi.org/10.1080/10715760600758522
Actis-Goretta L, Romanczyk LJ, Rodriguez CA, Kwik-Uribe, Keen CL. Cytotoxic effects ofdigalloyl dimer procyanidins in human cancer cell lines. J Nutr Biochem 2008; 19(12): 797-808. http://dx.doi.org/10.1016/j.jnutbio.2007.10.004
Ruberto G, Renda A, Daquino C, Amico V, Spatafora C, Tringali C. Polyphenol constituents and antioxidant activity of grape pomace extracts from five Sicilian red grape cultivars. J Food Chem 2007; 100(1): 203-10. http://dx.doi.org/10.1016/j.foodchem.2005.09.041
Singleton VL, Rossi JA. Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagent. A J Enol Viticult 1965; 16: 144-58.
Lamaison JLC, Carnet A. Teneurs en principaux flavonoids des fleurs de Crataegeusmonogyna Jacq et de Crataegeuslaevigata (Poiret D. C) enfonction de lavegetation. Pharmac Acta Helvetiae 1990; 65: 315-20.
Lee J, Durst RW, Wroistad RE. Determination of total monomeric anthocyanin pigment content of fruit juices, beverages, natural colorants, and wines by the pH differential method: collaborative study. J AOAC Int 2005; 88: 1269-78.
Arnous A, Makris DP, Kefalas P. Effect of principal polyphenolic components in relation to antioxidant characteristics of aged red wines. J Agric Food Chem 2001; 49: 5736-42. http://dx.doi.org/10.1021/jf010827s
Arnous A, Meyer AS. Comparison of methods for compositional characterization of grape (Vitis vinifera L.) and apple (Malusdomestica) skins. J Food Bioprod Proc 2008; 86: 79-86. http://dx.doi.org/10.1016/j.fbp.2008.03.004
Caillest S, Salmieri S, Lacroix M. Evaluation of free radical-scavenging properties of commercial grape phenol extracts by a fast colorimetric method. J Food Chem 2006; 95: 1-8. http://dx.doi.org/10.1016/j.foodchem.2004.12.011
Kiselova Y, Ivaniva D, Chervenkov T, Gerova D, Galunska B, Yankova T. Correlation between the in vitro antioxidant activity and polyphenol content of aqueous extracts from Bulgarian Herbs. Phytother Res 2006; 20: 961-65. http://dx.doi.org/10.1002/ptr.1985
Alonso AM, Guillen DA, Barroso CG, Purtas B, Garcla A. Determination of antioxidant activity of wine byproducts and its correlation with polyphenolic content. J Agric Food Chem 2002; 50: 5832-36. http://dx.doi.org/10.1021/jf025683b
Borbalan AMA, Zorro L, Guillen DA, Barroso CG. Study of the polyphenol content of red and white grape varieties by liquid chromatography-mass spectrometry and its relationship to antioxidant power. J Chromatogr A 2003; 1012: 31-38. http://dx.doi.org/10.1016/S0021-9673(03)01187-7
Pastrana-Bonilla E, Akoh CC, Sellappan S, Krewer G. Phenolic content and antioxidant capacity of muscadine grapes. J Agric Food Chem 2003; 51(18): 5497-503. http://dx.doi.org/10.1021/jf030113c
Guendez R, Kallithraka S, Makris DP, Kefalas P. Determination of low molecular weight polyphenolic constituents in grape (Vitis vinifera sp.) seed extracts: correlation with antiradical activity. Food Chem 2005; 89: 1-9. http://dx.doi.org/10.1016/j.foodchem.2004.02.010
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