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Inhibitory Effects of Leaves of Guava (Psidium guajava) on TPA-Induced Inflammation and Tumor Promotion in Two-Stage Carcinogenesis in Mouse Skin

Authors

  • Ken Yasukawa

    Nihon University, 7-7-1, Narashinodai, Chiba 274-8555, Japan

  • Tomohito Kakegawa

    JosaiInternationalUniversity, 1Gumyo, Togane, Chba283-8555 ,Japan

DOI:

https://doi.org/10.6000/1927-5951.2015.05.04.1

Keywords:

 Guava, Psidium guajava, antitumor promotion, anti-inflammation, cancer prevention.

Abstract

Cancer prevention offers the most cost-effective long-term health strategy. The methanol extract of the leaves of guava(Psidium guajava) exhibits marked antitumor activity in an in vivo two-stage carcinogenesis test in mice using 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and 12-O-tetradecanoylphorbol-13- acetate (TPA) as a promoter. From the active fraction of the methanol extract, five triterpene acids, uvaol (1), ursolic acid (2), corosolic acid (3), asiatic aci (4), and oleanolic acid d (5), were isolated and identified. These compounds were evaluated for their inhibitory effects on TPA-induced inflammation (1 µg/ear) in mice, and showed marked anti-inflammatory effects, with a 50% inhibitory dose of 117–657 nmol/ear. The leaves of guava may therefore be effective for cancer prevention.

References

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Published

2015-08-05

Issue

Vol. 5 No. 4 (2015)

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Articles

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Copyright (c) 2015 Ken Yasukawa , Tomohito Kakegawa

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

Inhibitory Effects of Leaves of Guava (Psidium guajava) on TPA-Induced Inflammation and Tumor Promotion in Two-Stage Carcinogenesis in Mouse Skin . (2015). Journal of Pharmacy and Nutrition Sciences , 5(4), 216-221. https://doi.org/10.6000/1927-5951.2015.05.04.1

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