Inhibitory Effects of Chaga (Inonotus Obliquus) on Tumor Promotion in Two-Stage Mouse Skin Carcinogenesis
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Keywords

 Chaga, Inonotus obliquus, lanostane-type triterpene, antitumor promotion, anti-inflammation, two-stage carcinogenesis.

How to Cite

Ayako Akita, Yi Sun, & Ken Yasukawa. (2015). Inhibitory Effects of Chaga (Inonotus Obliquus) on Tumor Promotion in Two-Stage Mouse Skin Carcinogenesis. Journal of Pharmacy and Nutrition Sciences, 5(1), 71–76. https://doi.org/10.6000/1927-5951.2015.05.01.11

Abstract

The methanol extract of chaga (sclerotia of Inonotus obliquus) inhibited the promoting effect of 12-O-tetradecanoylphorbol-13-acatate (TPA) applied twice weekly on skin tumor formation in mice initiated with 7,12-dimethylbenz [a] anthracene. The methanol extract from chaga led to the isolation of eight triterpenoids (1-8). The anti-inflammatory activity of the isolated lanostane-type triterpenes was evaluated against TPA-induced inflammatory ear edema in mice. These compounds showed markedly anti-inflammatory effects, with a 50% inhibitory dose of 125-458 nmol/ear.

https://doi.org/10.6000/1927-5951.2015.05.01.11
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References

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Copyright (c) 2015 Ayako Akita, Yi Sun , Ken Yasukawa